Yohimbe is an alkaloid extracted from the Yohimbe tree which supports healthy male sexual function and promotes weight loss.
Yohimbe Mode of Action
Yohimbe is an alkaloid of the Pausinystalia yohimbe tree and in the plants of the Rauwolfia family (1). It is also known as Corynanthe johimbi and Corynanthe yohimbe. The Yohimbe tree is native to central and western Africa, primarily the Congo, Cameroun, and Gabon. It has been used as an aphrodisiac in folklore (2).
The active indole alkaloid is found in the bark of the yohimbe tree. The bark can contain up to 0.6-1.38% of the yohimbe alkaloid, combined with other alkaloids chemicals that account for up to 6% of the content of the bark. Most supplements are standardized to the yohimbe content alone (2).
The aphrodisiac effects of yohimbe are due to the dilation of blood vessels in the genitals, increased reflex in the spinal cord, and the transmission of nerve impulses to genital tissue. The sexual enhancement effects are believed to be through increased blood flow to the genitals and central nervous system excitatory impulses for men. In women, the sexual enhancement effects are believed to be through increasing blood flow to the vagina and its blood vessels (2).
Yohimbine is one of Yohimbe’s constituents which works directly on the central nervous system by increasing sympathetic outflow and increasing the release of norepinephrine. Yohimbine also inhibits monoamine oxidase (MOA), peripheral serotonin receptors, calcium channels, and can deplete dopamine within the brain (2).
Yohimbine also promotes weight loss due to its ability to promote lipid metabolism, and it increases fat burning through inhibiting alpha-2 adrenoceptors on fat cells (2).
Pure Nootropics’ Yohimbe contains 2% bark plant extract (standardized to 2.2% Yohimbine HCL) and provides 5 mg per capsule. Suggested use for adults is 1 capsule by mouth daily.
Yohimbe Side Effects & Toxicity
If you are taking any medication, always consult your Practitioner before beginning supplementation with Yohiumbe.
For further information, please see our References Tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• Supports healthy male sexual function*
Susset, JG, et al. “Effect of Yohimbine Hydrochloride on Erectile Impotence: a Double-Blind Study.” J Urol., vol. 141, no. 6, June 1989, pp. 1360–3., https://www.ncbi.nlm.nih.gov/pubmed/2657105.
Ernst, E, and MH Pittler. “Yohimbine for Erectile Dysfunction: a Systematic Review and Meta-Analysis of Randomized Clinical Trials.” J Urol., vol. 159, no. 2, Feb. 1998, pp. 433–6., https://www.ncbi.nlm.nih.gov/pubmed/9649257.
• Promotes weight loss efforts*
Kucio, C, et al. “Does Yohimbine Act as a Slimming Drug?” Isr J Med Sci., vol. 27, no. 10, Oct. 1991, pp. 550–6., https://www.ncbi.nlm.nih.gov/pubmed/1955308.
Ostojic, SM. “Yohimbine: the Effects on Body Composition and Exercise Performance in Soccer Players.” Res Sports Med., vol. 14, no. 4, 2006, pp. 289–99., https://www.ncbi.nlm.nih.gov/pubmed/17214405.
1. “Yohimbine.” Examine.com, Last updated Jun 14, 2018. https://examine.com/supplements/yohimbine/
2. “Yohimbe.” Foods, Herbs & Supplements. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=759