Sulbutiamine is a derivative of Thiamine (Vitamin B1) that was first synthesized in Japan in the 1950s (1)(2).
Sulbutiamine Mode of Action
Sulbutiamine was synthesized to be fat-soluble and has a greater bioavailability than Vitamin B1 itself (1).
Pure Nootropics offers Sulbutiamine in capsules containing 200 mg in each capsule.
For further information, please see our References Tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• May reduce fatigue*
• May help with recovery after illness*
Shah, SN, and Sulbutiamine Study Group. “Adjuvant Role of Vitamin B Analogue (Sulbutiamine) with Anti-Infective Treatment in Infection Associated Asthenia.” J Assoc Physicians India, vol. 51, Sept. 2003, pp. 891–5., www.ncbi.nlm.nih.gov/pubmed/14710977.
The following are examples of dynamics associated with Sulbutiamine through the animal model and may not be representative of the effects in the human body:
• Supports memory (in mice)*
Micheau, J, et al. “Chronic Administration of Sulbutiamine Improves Long Term Memory Formation in Mice: Possible Cholinergic Mediation.” Pharmacol Biochem Behav., vol. 23, no. 2, Aug. 1985, pp. 195–8., www.ncbi.nlm.nih.gov/pubmed/4059305.
• May improve recognition (in rats)*
Bizot, JC, et al. “Chronic Treatment with Sulbutiamine Improves Memory in an Object Recognition Task and Reduces Some Amnesic Effects of Dizocilpine in a Spatial Delayed-Non-Match-to-Sample Task.” Prog Neuropsychopharmacol Bio Psychiatry, vol. 29, no. 6, July 2005, pp. 928–35., doi:10.1016/j.pnpbp.2005.04.035.
• May promote anti-oxidant activity (in vitro)*
Kang, KD, et al. “Sulbutiamine Counteracts Trophic Factor Deprivation Induced Apoptotic Cell Death in Transformed Retinal Ganglion Cells.” Neurochem Res., vol. 35, no. 11, Nov. 2010, pp. 1828–39., doi:10.1007/s11064-010-0249-5.
1. “Sulbutiamine”. Examine.com, published Sep 3, 2014, Last updated Jun 14, 2018. https://examine.com/supplements/sulbutiamine/.
2. “Sulbutiamine.” Wikipedia, en.wikipedia.org/wiki/Sulbutiamine.
3. “Thiamine Deficiency”. Wikipedia, en.wikipedia.org/wiki/Thiamine_deficiency.
4. “Sulbutiamine”. Foods Herbs & Supplements, Professional, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1285.
5. “Sulbutiamine. ” PubChem Open Chemistry Database, https://pubchem.ncbi.nlm.nih.gov/compound/Sulbutiamine.