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Sulbutiamine Capsules

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60 x 200mg Capsules
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PRODUCT INFORMATION
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PRODUCT INFORMATION

Sulbutiamine is a derivative of Thiamine (Vitamin B1) that was first synthesized in Japan in the 1950s (1)(2).

Sulbutiamine Benefits

  • May reduce fatigue (ref)*
  • May help with recovery after illness (ref)*

 

Sulbutiamine is a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for some studies referenced above.*

The following are examples of dynamics associated with Sulbutiamine through the animal model and may not be representative of the effects in the human body:

  • Supports memory (in mice) (ref)*
  • May improve recognition (in rats) (ref)*
  • May promote anti-oxidant activity (in vitro) (ref)*

Sulbutiamine Mode of Action

A deficiency in Vitamin B1 can cause cognitive deficits in memory and general cognition (2). The Japanese started researching the effect of diet and Vitamin B1 in the late nineteenth century due to a high mortality rate associated with sailors. They found that the highest incidence of Vitamin B1 deficiency was in the crew members who ate a diet of mostly white rice, and by improving the diet with a varied intake of meat and fish, barley, rice and beans, the mortality rate decreased. Vitamin B1 deficiency is commonly linked to a diet consisting of mostly processed white rice (3).

Sulbutiamine was synthesized to be fat-soluble and has a greater bioavailability than Vitamin B1 itself (1). Although not fully understood at this time, the benefits Sulbutiamine has for combating symptoms of fatigue is believed to be in its ability to upregulate the system involved in the sleep-wake state and fight vs. flight response. Animal research suggests that it may also work with the cholinergic, glutamatergic, and dopaminergic systems in the brain, which is believed to account for its cognitive benefits such as improving memory (4).

Sulbutiamine Capsules Dosage

Pure Nootropics’ Sulbutiamine Capsules provide 200 mg per 1 capsule. Suggested use for adults is up to 2 capsules by mouth daily, or as directed by your healthcare practitioner.

If you are taking any medications, always consult with you Healthcare Practitioner before beginning any new supplement.

Sulbutiamine Side Effects & Toxicity

If you are taking any medications, always consult with you Healthcare Practitioner before beginning any new supplement.

A lethal dose was achieved in rats at a dose of 5 gram/kg and in mice at 5 gm/kg (5).

 

For further information, please see our References Tab above.

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Reference

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• May reduce fatigue*
• May help with recovery after illness*

Shah, SN, and Sulbutiamine Study Group. “Adjuvant Role of Vitamin B Analogue (Sulbutiamine) with Anti-Infective Treatment in Infection Associated Asthenia.” J Assoc Physicians India, vol. 51, Sept. 2003, pp. 891–5., www.ncbi.nlm.nih.gov/pubmed/14710977.
The following are examples of dynamics associated with Sulbutiamine through the animal model and may not be representative of the effects in the human body:
• Supports memory (in mice)*
Micheau, J, et al. “Chronic Administration of Sulbutiamine Improves Long Term Memory Formation in Mice: Possible Cholinergic Mediation.” Pharmacol Biochem Behav., vol. 23, no. 2, Aug. 1985, pp. 195–8., www.ncbi.nlm.nih.gov/pubmed/4059305.
• May improve recognition (in rats)*
Bizot, JC, et al. “Chronic Treatment with Sulbutiamine Improves Memory in an Object Recognition Task and Reduces Some Amnesic Effects of Dizocilpine in a Spatial Delayed-Non-Match-to-Sample Task.” Prog Neuropsychopharmacol Bio Psychiatry, vol. 29, no. 6, July 2005, pp. 928–35., doi:10.1016/j.pnpbp.2005.04.035.
• May promote anti-oxidant activity (in vitro)*
Kang, KD, et al. “Sulbutiamine Counteracts Trophic Factor Deprivation Induced Apoptotic Cell Death in Transformed Retinal Ganglion Cells.” Neurochem Res., vol. 35, no. 11, Nov. 2010, pp. 1828–39., doi:10.1007/s11064-010-0249-5.

1. “Sulbutiamine”. Examine.com, published Sep 3, 2014, Last updated Jun 14, 2018. https://examine.com/supplements/sulbutiamine/.
2. “Sulbutiamine.” Wikipedia, en.wikipedia.org/wiki/Sulbutiamine.
3. “Thiamine Deficiency”. Wikipedia, en.wikipedia.org/wiki/Thiamine_deficiency.
4. “Sulbutiamine”. Foods Herbs & Supplements, Professional, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1285.
5. “Sulbutiamine. ” PubChem Open Chemistry Database, https://pubchem.ncbi.nlm.nih.gov/compound/Sulbutiamine.

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Sulbutiamine Capsules

Sulbutiamine Capsules

$12.99
60 x 200mg Capsules
180 x 200mg Capsules
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