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Pterostilbene Capsules

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PRODUCT INFORMATION
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PRODUCT INFORMATION

Pterostilbene is a phenol similar to resveratrol and is found in blueberries and grapes.

Pterostilbene Benefits

  • Pterostilbene has a higher bioavailability and is better absorbed than resveratrol (ref)*
  • Promotes cellular health while aging when paired with NAD+ Precursors (ref)*(ref)*

 

Pterostilbene is emerging as a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for those studies referenced above.*

The following are examples of dynamics associated with Pterostilbene through the animal model and may not be representative of the effects in the human body:

  • Promotes healthy energy metabolism (in rats) (ref)*
  • May reduce oxidative stress (in human cells in vitro) (ref)*
  • May support mood in preliminary studies (in mice) (ref)*
  • May promote cognitive health during aging (in animals) (ref)*

Pterostilbene Mode of Action

Pterostilbene is a polyphenol contained in plants, fruits, and nuts, with the highest concentration in blueberries and grapes (1, 2). It is very similar to resveratrol and differs only through two methoxy groups on the molecule instead of the two hydroxy groups found on the resveratrol molecule. Both resveratrol and Pterostilbene are phytoalexins, compounds that plants produce which function as self-defense against insects and parasites (1).

Pterostilbene is more potent than resveratrol and has a higher bioavailability (1).

Pterostilbene used individually has many benefits but human studies are scarce. It may reduce blood pressure in humans when used on its own (6). However, some of its best abilities to promote healthy aging have been studied in humans.

Pterostilbene, when combined with NAD (nicotinamide riboside) intermediate products such as Tru Niagen® which contains nicotinamide riboside (NR), promotes cellular health while aging due to its ability to raise NAD levels (nicotinamide adenine dinucleotide) (3). NAD biosynthesis in mammals is a pathway involved in cells throughout the body and is believed to regulate the process of aging. Nicotinamide is converted into NMN which is then converted into NAD. Intermediate enzymes, like nicotinamide riboside (NR), increase the available NAD and contributes to overall longevity and cellular health in the body (4). A randomized, double-blind, placebo-controlled study followed the effects of pairing Pterostilbene with NR and found that it was an effective way to raise NAD levels, and thus contribute to cellular health and fitness while aging (3). Combining NR and Pterostilbene may also increase LDL cholesterol as demonstrated in human clinical studies (2).

 

Pterostilbene Dosage

Pure Nootropics’ Pterostilbene provides 100 mg per 1 capsule. Suggested use for adults is 1 capsule by mouth once daily, or as directed by your healthcare practitioner.

If you are taking any medications, always consult with you Healthcare Practitioner before beginning any new supplement.

Pterostilbene Side Effects and Toxicity

Human trials have indicated that Pterostilbene is generally safe in doses of up to 250 mg/day and well-tolerated in twice daily dose frequency (5). Pterostilbene may increase LDL (low-density lipoprotein) cholesterol (6).

For further information, please see our References Tab above.

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Reference

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• Pterostilbene has a higher bioavailability and is better absorbed than resveratrol*
“Pterostilbene”. Examine.com, published Aug 5, 2014. Last updated Jun 14, 2018. doi:10.12688/f1000research.12120.1.
• Promotes cellular health while aging when paired with TRU NIAGEN®(nicotinamide riboside) *
Dellinger, Ryan W., et al. “Repeat Dose NRPT (Nicotinamide Riboside and Pterostilbene) Increases NAD Levels in Humans Safely and Sustainably: a Randomized, Double-Blind, Placebo-Controlled Study.” NPJ Aging and Mechanisms of Disease, vol. 3, no. 17, 2017, www.nature.com/articles/s41514-017-0016-9.
Johnson, Sean, and Shin-Ichiro Imai. “NAD + biosynthesis, aging, and disease.” F1000Research vol. 7 132. 1 Feb. 2018, doi:10.12688/f1000research.12120.1.

The following are examples of dynamics associated with Pterostilbene through the animal model and may not be representative of the effects in the human body:
• Promotes healthy energy metabolism (in rats)*
Nagao, K, et al. “Pterostilbene, a Dimethylated Analog of Resveratrol, Promotes Energy Metabolism in Obese Rats.” J Nutr Biochem, vol. 43, May 2017, pp. 151–155., doi:10.1016/j.jnutbio.2017.02.009.
• May reduce oxidative stress (in human cells in vitro)*
Yang, Y, et al. “Pterostilbene Attenuates High Glucose-Induced Oxidative Injury in Hippocampal Neuronal Cells by Activating Nuclear Factor Erythroid 2-Related Factor 2.” Biochim Biophys Acta Mol Basis Dis., vol. 1863, no. 4, Apr. 2017, pp. 827–837., doi:10.1016/j.bbadis.2017.01.005.
• May support mood in preliminary studies (in mice)*
Al Rahim, M, et al. “Anxiolytic Action of Pterostilbene: Involvement of Hippocampal ERK Phosphorylation.” Planta Med, vol. 79, no. 9, June 2013, pp. 723–30., doi:10.1055/s-0032-1328553.
• May promote cognitive health during aging (in animals)*
La Spina, M, et al. “Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study.” Cell Physiol Biochem, vol. 52, no. 2, 2019, pp. 232–239., doi:10.33594/000000017.

1. “Pterostilbene”. Examine.com, published Aug 5, 2014. Last updated Jun 14, 2018. https://examine.com/supplements/pterostilbene/.
2. Brenner, Charles, and Amy C. Boileau. “Pterostilbene Raises Low Density Lipoprotein Cholesterol in People.” Clinical Nutrition, vol. 38, no. 1, Feb. 2019, pp. 480–1., doi:https://doi.org/10.1016/j.clnu.2018.10.007.
3. Dellinger, Ryan W., et al. “Repeat Dose NRPT (Nicotinamide Riboside and Pterostilbene) Increases NAD Levels in Humans Safely and Sustainably: a Randomized, Double-Blind, Placebo-Controlled Study.” NPJ Aging and Mechanisms of Disease, vol. 3, no. 17, 2017, www.nature.com/articles/s41514-017-0016-9.
4. Johnson, Sean, and Shin-Ichiro Imai. “NAD + biosynthesis, aging, and disease.” F1000Research vol. 7 132. 1 Feb. 2018, doi:10.12688/f1000research.12120.1.
5. Daniel M. Riche, Corey L. McEwen, Krista D. Riche, et al., “Analysis of Safety from a Human Clinical Trial with Pterostilbene,” Journal of Toxicology, vol. 2013, Article ID 463595, 5 pages, 2013. https://doi.org/10.1155/2013/463595.
6. Riche, DM, et al. “Pterostilbene on Metabolic Parameters: a Randomized, Double-Blind, and Placebo-Controlled Trial.” Evid Based Complement Alternat Med., vol. 2014, no. 459165, 2014, doi:10.1155/2014/459165.

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Pterostilbene Capsules

Pterostilbene Capsules

$19.99
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