Agmatine is a decarboxylated derivative of the amino acid L-arginine (1).
Agmatine Sulfate Mode of Action
Agmatine is an amine molecule that is involved in signaling in the human body. It is a bacterial byproduct and can be found in fermented foods such as wine, beer, sake, fish, meat products, and coffee (1).
Agmatine is endogenously produced and is found in the spinal cord and brain. Agmatine interacts with cell-specific receptors and interacts with actions within the central nervous system. However, its role in brain function has not yet been determined because researchers are still studying its biosynthesis and degradation (4).
Agmatine Sulfate Dosage
Pure Nootropics’ Agmatine Sulfate provides 500 mg per 1 capsule.
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2. “Arginine.” Examine.com, published Oct 16, 2014. Last updated Jun 14, 2018. https://examine.com/supplements/arginine/.
4. Reis, DJ, and S Regunathan. “Agmatine: a Novel Neurotransmitter?” Adv. Pharmacol, vol. 42, 1998, pp. 645–9., www.ncbi.nlm.nih.gov/pubmed/9327985.
5. Arndt, Mary Ann et al. “The arginine metabolite agmatine protects mitochondrial function and confers resistance to cellular apoptosis.” American journal of physiology. Cell physiology vol. 296,6 (2009): C1411-9. doi:10.1152/ajpcell.00529.2008
6. Gilad, GM, and VH Gilad. “Evidence for Oral Agmatine Sulfate Safety–a 95-Day High Dosage Pilot Study with Rats.” Food Chem Toxicol., vol. 62, Dec. 2013, pp. 758–62., doi:10.1016/j.fct.2013.10.005.