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Milk Thistle Capsules

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PRODUCT INFORMATION
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PRODUCT INFORMATION

Milk Thistle (Silybum Marianum) is a plant containing the flavonolignan Silymarin in its fruits or thistles (1).

Milk Thistle Benefits

  • May support healthy liver enzymes (ref)*

 

Milk Thistle is emerging as a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for those studies referenced above.*

The following are examples of dynamics associated with Milk Thistle through the animal model:

  • May promote anti-oxidant activity in the liver (of mice) (ref)*
  • Promotes neural health (in animal in-vitro studies) (ref)*

Milk Thistle Mode of Action

Milk Thistle contains 1.5-3% Silymarin before extraction in its dry weight. It is extracted from the seeds for supplement use via ethanol and contains 65-80% of Silymarin, which is a specific polyphenol called a flavonolignan. Silymarin has 7 flavonolignan constituents unique to milk thistle: Silybinin, Isosilibin, Silychristine, Sildydianin, and Taxifolin (a nearly undetectable level of Quercetin called dihydroquercetin) (1).

Milk Thistle’s hepatoprotective (liver protective) effects are believed to be due to its ability to increase protein synthesis in liver cells and facilitate repair of liver cells after injury (1). Milk Thistle has been shown to decrease elevated levels of liver enzymes such as bilirubin, alanine transaminase, and aspartate transaminase, while improving the health of cells at a histologic (microscopic) level (3).

The research in animals and in vitro have suggested its ability to act as an antioxidant specifically targeting liver cells (3) and working as a mediator in decreasing and protecting neural cells from oxidative demise (4).

Milk Thistle has also been useful in cases of poisonous mushroom toxicity because the Silibinin in Milk Thistle extracts can block cellular mushroom toxins (amatoxins) from being recirculated through the liver (5).

Milk Thistle Capsules & Dosage

Pure Nootropics’ Milk Thistle Capsules provide 250 mg of Milk Thistle Seed Extract (80% Silymarin) per 1 capsule. Suggested use for adults is 1 to 2 capsules by mouth daily for best results, or as directed by your healthcare practitioner.

Milk Thistle Side Effects and Toxicity

Milk Thistle is generally well tolerated. Side effects are rare and may include gastrointestinal symptoms such as pain, nausea, or vomiting, and very rare reports of rash, pruritus, eczema, and anaphylaxis (6).

A lethal dose was achieved for silymarin at doses of 300 mg/kg in dogs and rabbits and 900-1000 mg/kg in rodents (7).

CAUTION: If you are allergic to plant members of the aster family (also known as Asteraceae/Compositae family), do not use Milk Thistle (6).

If you are taking any medications, please consult with your healthcare practitioner before beginning supplementation with Milk Thistle.

For further information, please see our References Tab above.

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Reference

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• May support healthy liver enzymes*
Feher J, Deak G, Muzes G, Lang I, Niederland V, Nekam K, et al. Liver-protective action of silymarin therapy…[Hungarian]. Orv Hetil. 1989;130:2723–7.

The following are examples of dynamics associated with Milk Thistle through the animal model:
• May promote anti-oxidant activity in the liver (of mice)*
Vargas-Mendoza, Nancy et al. “Hepatoprotective effect of silymarin.” World journal of hepatology vol. 6,3 (2014): 144-9. doi:10.4254/wjh.v6.i3.144.
• Promotes neural health (in animal in-vitro studies)*
Kittur, S, et al. “Neurotrophic and Neuroprotective Effects of Milk Thistle (Silybum Marianum) on Neurons in Culture.” J Mol Neurosci., vol. 18, no. 3, June 2002, pp. 265–9., www.ncbi.nlm.nih.gov/pubmed/12059045.

1. “Milk Thistle.” Examine.com, Published Jul 17, 2013. Last updated Jun 14, 2018. https://examine.com/supplements/milk-thistle/.
2. Feher J, Deak G, Muzes G, Lang I, Niederland V, Nekam K, et al. Liver-protective action of silymarin therapy in chronic alcoholic liver diseases [Hungarian]. Orv Hetil. 1989;130:2723–7.
3. Vargas-Mendoza, Nancy et al. “Hepatoprotective effect of silymarin.” World journal of hepatology vol. 6,3 (2014): 144-9. doi:10.4254/wjh.v6.i3.144.
4. Kittur, S, et al. “Neurotrophic and Neuroprotective Effects of Milk Thistle (Silybum Marianum) on Neurons in Culture.” J Mol Neurosci., vol. 18, no. 3, June 2002, pp. 265–9., www.ncbi.nlm.nih.gov/pubmed/12059045.
5. Mengs, U, et al. “Legalon® SIL: the Antidote of Choice in Patients with Acute Hepatotoxicity from Amatoxin Poisoning.” Curr Pharm Biotechnol., vol. 13, no. 10, Aug. 2012, pp. 1964–70., www.ncbi.nlm.nih.gov/pubmed/22352731.
6. Rainone, Francine. “Milk Thistle.” American Family Physician, vol. 72, no. 7, Oct. 2005, www.aafp.org/afp/2005/1001/p1285.html.
7. “Milk Thistle.” Foods, Herbs & Supplements. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=138#adverseEvents.

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Milk Thistle Capsules

Milk Thistle Capsules

$13.99
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