NMN is a NAD+ precursor which supports healthy aging.
- Supports NAD+ Production (ref)*
NMN Mechanism of Action
Nicotinamide Mononucleotide (NMN) is a nucleotide which is a precursor to NAD (Nicotinamide adenine dinucleotide). NAD is a cofactor found in all living cells and is necessary for cellular reactions (1).
Maintaining higher levels of NAD increases levels of the energy molecule, ATP, and is vital to DNA repair, gene expression, and signaling between cells. Lower levels of NAD are associated with aging and age-related degeneration (2).
Many NAD precursors are available as supplements to increase levels of NAD in the body. Each precursor has a unique pathway which usually involves breaking down into Nicotinamide Riboside (NR). NR is a type of Vitamin B3 (3). Like NR, Nicotinamide Mononucleotide can be found in some food sources, but only in trace amounts. These food sources include broccoli, cabbage, cucumbers, tomatoes, avocados, and edamame (4).
It was previously believed that NR was the only NAD precursor that could enter the cell, and that supplementing with NR was a more direct way to synthesize NAD. Generally, NMN requires an extra step which converts NMN into NR before entering the cell and then is converted back into NMN through another phosphorylation process (5).
However, scientists recently discovered that a membrane protein (Slc12a8) is specific for NMN transport directly across the cell membrane and into the cell. This protein requires sodium in order to transport the NMN (5).
NMN has advantages over other NAD precursors, specifically regarding Sirtuin interactions (7).
Pure Nootropics' NMN provides 350 mg per (2) capsules. Suggested use for adults is 2 capsules by mouth daily or as recommended by your healthcare practitioner.
If you are taking any medications, please consult with your healthcare practitioner before beginning supplementation.
For more information, please see our references tab.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. This product is sold as a research chemical and is for research purposes only; we recommend consulting a professional about how to handle this chemical. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• Supports NAD+ production*
Irie, J, et al. “Effect of Oral Administration of Nicotinamide Mononucleotide on Clinical Parameters and Nicotinamide Metabolite Levels in Healthy Japanese Men.” Endocr J., 2 Nov. 2019, doi:10.1507/endocrj.EJ19-0313.
1. “Nicotinamide Adenine Dinucleotide.” Wikipedia, https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide.
2. Aman, Yahyah, et al. “Therapeutic Potential of Boosting NAD in Aging and Age-Related Diseases.” Translational Medicine of Aging, vol. 2, Jan. 2018, pp. 30–37., doi:https://doi.org/10.1016/j.tma.2018.08.003.
3. Chi, Yuling, and Anthony A. Suave. “Nicotinamide Riboside, a Trace Nutrient in Foods, Is a Vitamin B3 with Effects on Energy Metabolism and Neuroprotection.” Curr Opin Clin Nutr Metab Care, vol. 16, 2013, pp. 657–661., doi:10.1097/MCO.0b013e32836510c0.
4. Mills, Kathryn F., et al. “Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.” Cell Metabolism, vol. 24, no. 6, 13 Dec. 2016, pp. 795–806., doi:https://doi.org/10.1016/j.cmet.2016.09.013.
5. Hill, Steve. “NMN Enters Cells via Newly Discovered Pathway.” 9 Jan. 2019, https://www.leafscience.org/nad-transporter-identified/.
6. Grozio, Alessia, et al. “Slc12a8 Is a Nicotinamide Mononucleotide Transporter.” Nature Metabolism, vol. 1, 2019, pp. 47–57., https://www.nature.com/articles/s42255-018-0009-4.
7. “Nicotinamide Mononucleotide, an NAD Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner.” Journal of the American Society of Nephrology, vol. 28, no. 8, Aug. 2017, pp. 2337–2352., doi:https://doi.org/10.1681/ASN.2016040385.
8. Irie, J, et al. “Effect of Oral Administration of Nicotinamide Mononucleotide on Clinical Parameters and Nicotinamide Metabolite Levels in Healthy Japanese Men.” Endocr J., 2 Nov. 2019, doi:10.1507/endocrj.EJ19-0313.