KSM-66® Ashwagandha is an expertly formulated extract of Ashwagandha containing the highest concentration of the root available today, created by Ixoreal Biomed after 14 years of refinement (1).
Ashwagandha is a treasured plant in Indian Aryuvedic philosophy. It is a nervine tonic and an adaptogen, or an herb that can promote a healthier response to stress (2).
Pure Nootropics has chosen the high-quality, standardized extract of Ashwagandha root present in KSM-66® Ashwagandha to provide the benefits of this traditional herb in a contemporary and accessible form.
KSM-66® Ashwagandha Benefits
KSM-66® Ashwagandha extract has been clinically tested in humans and has strong evidence to support its benefits (1):
- Mood and stress support (ref)*
- Supports sexual health in males (ref)* and females (ref)*
- Promotes a healthy body weight (ref)*
- Supports cognitive health (ref)*
- May enhance cardiorespiratory fitness (ref)*
- May promote muscle recovery after resistance-training exercise (ref)*
KSM-66® Ashwagandha Mode of Action
Ashwagandha (Withania somnifera) is sometimes called “Indian ginseng” because of its similar functions to the Ginseng plants and its function as an adaptogen. However, only plants belonging to the genus Panax which contain ginsenosides are considered true ginsengs (3).
The root of the Ashwagandha plant is the part of the plant commonly used medicinally but the root and leaves can also be utilized topically. The bioactive chemical constituents include the steroidal lactones of withanolides and withaferins, alkaloids, and saponins. Other chemical compounds found in the aerial parts of the plant contain withanolide-R and withasomniferin-A (2).
Research in animals (which may not be representative of the effects in the human body) suggest that Ashwagandha creates an anti-stress effect through corticosterone signaling and suppressing glutamate neuron excitations, notably through the withanolide glycosides. Although it is not fully understood at this time, Ashwagandha appears to protect the animal brain from glutamate-induced neurotoxicity. Withanolides can induce antioxidant activity after ingestion and may also prevent corticosterone (a glucocorticoid) release, creating a neuroprotective effect in animals (4).
Further research in animals (which, again, may not be representative of the effects in the human body) suggests that Withanolide-A works on the cholinergic system by inhibiting acetylcholinesterase (the enzyme that breaks down the neurotransmitter, acetylcholine). Ashwagandha may increase serotonin receptor signaling and enhances the signals through GABAa receptors (a subclass of GABA receptors). Ashwagandha’s effects on the adrenergic neurotransmission pathways are also not understood at this time but suggest its involvement in this area (4).
KSM-66® Ashwagandha Capsules
Pure Nootropics’ KSM-66® Ashwagandha Capsules provide 300 mg per capsule. Suggested use for adults is 1 capsule by mouth up to three times daily, or as directed by your healthcare practitioner.
KSM-66® Ashwagandha Capsules Side Effects & Toxicity
The formulation of KSM-66® Ashwagandha involves milk, and this product contains milk constituents (1).
Side effects to Ashwagandha may include gastrointestinal upset such as diarrhea and vomiting; and rarely, dizziness, irregular heartbeat, and burning/itching/discoloration of the skin (5).
Do not use if you are pregnant or nursing (5).
For further information, please see our References Tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• Mood and stress support*
Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019 Sep;98(37):e17186. doi: 10.1097/MD.0000000000017186. PMID: 31517876; PMCID: PMC6750292.
• Supports sexual health in males* and females*
Vijay R. Ambiye, Deepak Langade, Swati Dongre, Pradnya Aptikar, Madhura Kulkarni, and Atul Dongre, “Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 571420, 6 pages, 2013. https://doi.org/10.1155/2013/571420.
Swati Dongre, Deepak Langade, and Sauvik Bhattacharyya, “Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study,” BioMed Research International, vol. 2015, Article ID 284154, 9 pages, 2015. https://doi.org/10.1155/2015/284154.
• Promotes a healthy body weight*
Choudhary, Dnyanraj et al. “Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial” Journal of evidence-based complementary & alternative medicine vol. 22,1 (2016): 96-106.
• Supports cognitive health*
Choudhary, Dnyanra, et al. “Efficacy and Safety of Ashwagandha (Withania Somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.” Journal of Dietary Supplements, 2017, doi:10.1080/19390211.2017.1284970.
• May enhance cardiorespiratory fitness*
Choudhary, Bakhtiar et al. “Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults” Ayuvol. 36,1 (2015): 63-8.
• May promote muscle recovery after resistance-training exercise*
Wankhede, Sachin, et al. “Examining the Effect of Withania Somnifera Supplementation on Muscle Strength and Recovery: a Randomized Controlled Trial.” Journal of the International Society of Sports Nutrition, vol. 12, no. 43, 2015, doi:https://doi.org/10.1186/s12970-015-0104-9.
1. “What Is KSM-66?” ksm66ashwagandhaa.com/ksm-66/what-is-ksm-66/.
2. Singh, Narendra et al. “An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda” African journal of traditional, complementary, and alternative medicines : AJTCAM vol. 8,5 Suppl (2011): 208-13.
3. Yun TK. Brief introduction of Panax ginseng C.A. Meyer . J Korean Med Sci. (2001). https://examine.com/supplements/panax-ginseng/#ref10.
4. “Ashwagandha,” Examine.com, published on 23 February 2014, last updated on 18 January 2019, https://examine.com/supplements/ashwagandha/.
5. “Ashwagandha Natural Medicines, Foods, Herbs & Supplements, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=953#adverseEvents.