5-HTP (5-Hydroxytryptophan) is a metabolite of L-tryptophan, the amino acid necessary for the synthesis of the neurotransmitter serotonin (3). Adequate levels of serotonin support mood and restful sleep in this botanical nootropic.
- Supports maintaining a healthy weight (ref)*
- Mood support and promotes relaxation (ref)*
- Promotes healthy sleep (ref)*
5-HTP Mode of Action
Serotonin: the feel-good neurochemical we all need. Some of us don’t get enough of it, and we can have a sour mood, difficulty maintaining a healthy weight, and disturbed sleep when our reserves are running low.
Fortunately, nature has given us a solution in the form of a botanical extract which is rich in the precursors our bodies need to make serotonin, 5-HTP.
5-HTP is an extract of the shrub Griffonia simplicifolia which contains tryptophan, one of the necessary building blocks for serotonin synthesis within the body. Choosing to supplement with 5-HTP is an effective shortcut that’s already done half the work for you by providing your body with serotonin’s most direct precursor. It’s more effective than supplementing with tryptophan alone, and with 70% of the 5-HTP you take going straight to the bloodstream, it’s a biohack you’re sure to feel good about! (2)
5-HTP is very powerful because of its direct role in serotonin synthesis. Please be aware of any interactions before purchasing.
Pure Nootropics’ 5-HTP provides 100 mg per 1 capsule. Suggested use in adults is 1 capsule by mouth daily, or as directed by your healthcare practitioner.
If you are taking any medications, please consult with your healthcare practitioner before beginning supplementation with 5-HTP. Do not use if pregnant or nursing.
For further information, please see our References Tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• Supports maintaining a healthy weight (ref)*
Cangiano, C, et al. “Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects Treated with 5-Hydroxytryptophan.” Am J Clin Nutr., vol. 56, no. 5, Nov. 1992, pp. 863–7., www.ncbi.nlm.nih.gov/pubmed/1384305.
• Mood support (ref)*
Jangid, P, et al. “Comparative Study of Efficacy of l-5-Hydroxytryptophan and Fluoxetine in Patients Presenting with First Depressive Episode.” Asian J Psychiatr., vol. 6, no. 1, Feb. 2013, pp. 29–34., doi:10.1016/j.ajp.2012.05.011.
• Promotes healthy sleep (ref)*
Birdsall, TC. “5-Hydroxytryptophan: a Clinically-Effective Serotonin Precursor.” Alternative Medicine Review, vol. 3, no. 4, Aug. 1998, pp. 271–80., www.ncbi.nlm.nih.gov/pubmed/9727088.
1. “5-HTP”. Published Jul 21, 2013. Updated Feb 11, 2019. https://examine.com/supplements/5-htp/.
2. Charles, Gant. “The Role of 5HTP as a Precursor for Serotonin and Melatonin…” pdfs.semanticscholar.org/13b8/bb6db36e7453c83355f35a069713af84d4ba.pdf.
3. Birdsall, TC. “5-Hydroxytryptophan: a Clinically-Effective Serotonin Precursor.” Alternative Medicine Review, vol. 3, no. 4, Aug. 1998, pp. 271–80., www.ncbi.nlm.nih.gov/pubmed/9727088.
4. “5-HTP”. Food, Herbs, & Supplements Professional. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=794#mechanismOfAction.
5. “Serotonin Syndrome.” Wikipedia, en.wikipedia.org/wiki/Serotonin_syndrome.
6. “5-Hydroxytryptophan (Compound).” PubChem Open Chemistry Database, pubchem.ncbi.nlm.nih.gov/compound/5-hydroxytryptophan#section=Toxicity.