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Smart PS™ (Phosphatidylserine) Softgels


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Phosphatidylserine is a nutrient for cognitive function which is formulated into a shelf-stable soft gel capsule by Soft Gel Technologies. Smart PS™ provides the phospholipid Phosphatidylserine in a durable and convenient fluid dispersion material that prevents degradation.

Smart PS™ Benefits

  • Supports cognitive function for the elderly with age-related cognitive decline (ref)*
  • Supports healthy memory during age-related cognitive decline (ref)*
  • Mood and Stress Support (ref)*
  • May improve athletic performance (ref)*

Smart PS™ Mode of Action

Phosphatidylserine (PS) is a naturally occurring phospholipid present in membranes of cells. It is a cofactor for enzymes that work within signaling pathways, such as protein kinase C (PKC) (1). In all species, Phosphatidylserine is found in a structure of the cell membrane known as the lipid bilayer. PS increases cell fluidity and positively upregulates enzymes including ATPase and downregulates acetylcholinesterase (the enzyme that breaks down acetylcholine). Phosphatidylserine is found in the human brain, kidneys, lungs, testes, liver, heart, skeletal muscle and blood plasma. Over half of the PS found in the body is stored in neural tissue (2).

PS is necessary for healthy nerve cell membranes and myelin neural sheaths. Supplementing with PS is absorbed well in humans and crosses the blood-brain barrier where it may improve the natural deterioration of nerve cells associated with aging (3). Inadequate levels of PS inhibit brain cells from transmitting nerve signals properly (4).

PS specifically supports the memory including creating new memories, consolidating long-term memories, forming short-term memories, retrieving memories, and the ability to learn and recall information. PS also supports rapid reactions, reflexes, communication skills and language skills, and the ability to focus and concentrate (3).

The average dietary intake of PS is approximately 130 mg/day (2). PS for supplementation can be derived from bovine brain cortex (BC-PS) or soybeans (soy-PS) or synthetically manufactured (5). Bovine brain cortex is not a safe source of PS because of the risk of prion diseases like bovine spongiform encephalopathy. Soy lecithin is about 3% PS itself. Krill oil contains mostly phosphatidylcholine, rather than phosphatidylserine, and has not been a confirmed source of PS at this time (2).

Smart PS™ is a softgel enhanced with stability, as PS has a highly unstable nature. It is derived from soy lecithin and has demonstrated shelf stability of two years due to its exclusive fluid dispersion material (4).

Smart PS™ Dosage 

Pure Nootropics’ Smart PS™ (Phosphatidylserine) provides 100 mg of Phosphatidylserine, 25 mg of Phosphatidylcholine, and 2.5 mg of Phosphatidylethanolamine. Suggested use for adults is 1-3 capsules by mouth daily, or as directed by your healthcare practitioner.

Smart PS™ Side Effects and Toxicity

The source of PS can be a safety concern because many studies and clinical research used bovine-cortex derived PS. The fears of contamination with diseased animals has prompted the synthesis of PS from soy or cabbage sources. Plant-derived PS has been safely used in clinical studies for up to 6 months (6).

PS is generally well-tolerated.

If you are taking any medications, please consult your healthcare practitioner before beginning supplementation with PS.

A lethal dose in animal research was not achieved at a dose of 70 grams daily (6).

For further information, please see our References Tab above.


The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• Supports cognitive function for the elderly with age-related cognitive decline*
Cenacchi, T, et al. “Cognitive Decline in the Elderly: a Double-Blind, Placebo-Controlled Multicenter Study on Efficacy of Phosphatidylserine Administration.” Aging (Milano), vol. 5, no. 2, Apr. 1993, pp. 123–33.,
• Supports healthy memory during age-related cognitive decline*
Crook, TH, et al. “Effects of Phosphatidylserine in Age-Associated Memory Impairment.” Neurology, vol. 41, no. 5, May 1991, pp. 644–9.,
• Mood and Stress Support*
Hellhammer J, Vogt D, Franz N, Freitas U, Rutenberg D. A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids Health Dis. 2014 Jul 31;13:121. doi: 10.1186/1476-511X-13-121. PMID: 25081826; PMCID: PMC4237891.
• May improve athletic performance*
Kingsley, MI, et al. “Effects of Phosphatidylserine on Exercise Capacity during Cycling in Active Males.” Med Sci Sports Exerc., vol. 38, no. 1, Jan. 2006, pp. 64–71.,

1. Vance, JE, and R Steenbergen. “Metabolism and Functions of Phosphatidylserine.” Prog Lipid Res., vol. 44, no. 4, July 2005, pp. 207–34.,
2. “Phosphatidylserine”. Published April 10, 2013. Last updated June 14, 2018.
3. Glade, MJ, and K Smith. “Phosphatidylserine and the Human Brain.” Nutrition., vol. 31, no. 6, June 2015, pp. 781–6., <a href="http://doi.iorg/10.1016/j.nut.2014.10.014” rel=”noopener” target=”_blank”><a href="” rel=”noopener” target=”_blank”>doi:10.1016/j.nut.2014.10.014.
4. “Smart PS Phosphatidylserine”.
5. Cognitive Effects of Nutraceuticals, Jason Pitt, Yiuka Leung, in Nutraceuticals, 2016.

6. “Phosphatidylserine.” Foods Herbs & Supplements, Professional,,-herbs-supplements/professional.aspx?productid=992#background.


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Smart PS™ (Phosphatidylserine) Softgels

Smart PS™ (Phosphatidylserine) Softgels