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Lion's Mane 8:1 Mushroom Extract Capsules

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Lion’s Mane (Hericium erinaceus, also known as Yamabushitake) is a mushroom that supports mood, general wellbeing, and overall cognition.

Lion’s Mane Mushroom Benefits

Pure Nootropics provides mushroom extract, using organic whole fruiting bodies which are rigorously tested and guaranteed pure.

  • May provide mood support (ref)*
  • Supports overall cognitive health (ref)*

Lion’s Mane is emerging as a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for those studies referenced above.*

The following are examples of dynamics associated with Lion’s Mane through the animal model and may not be representative of the effects in the human body:

  • May enhance nerve-growth factor (ref)*
  • May promote healthy blood sugar (ref)*
  • May promote increased energy levels (ref)*

Lion’s Mane Mushroom Mode of Action

As a mushroom, the primary active compounds are polysaccharides, or beta-glucans. The fruiting body of the mushroom contains the highest content of the B-glucan polysaccharides. The polysaccharides stimulate the immune system and have antioxidant properties (1).

Lion’s Mane Mushroom may provide mood support and promote general wellbeing, as demonstrated in one of the very few human studies available to date (2)* . Lion’s Mane Mushroom may also support overall cognitive health and may improve cognitive function (3), as demonstrated in one of the very few human studies available as well.*

The studies in animal models may not be representative of Lion’s Mane’s effects in the human body, but have shown promise in the area of possibly enhancing nerve-growth factor (4), possibly promoting healthy blood sugar (5), and may promote increased energy levels (6). More research is needed in these areas.

Lion’s Mane Mushroom 8:1 Extract Capsules & Dosage

Pure Nootropics’ Lion’s Mane Mushroom 8:1 Extract Capsules provide 500 mg per 1 capsule. Suggested use for adults is 1 capsule by mouth daily, or as directed by your healthcare practitioner. The major difference between our 8:1 Lion's Mane Mushroom extract and our 1:1 Lion's Mane Mushroom is that the 8:1 is a dual extract (water and ethanol) meant to get certain beneficial compounds out of the mushroom that are not water soluble, specifically hericenones and erinacines. Hericenones and erinacines are a hot topic of study as they have been shown to increase Nerve Growth Factor (NGF) in rats. The 1:1 extract is a hot water extract that is high(er) in polysaccharides (than the 8:1) and is recommended for overall well-being, whereas the 8:1 is more suitable for cognitive support.

Lion’s Mane Mushroom 8:1 Extract Capsules Side Effects and Toxicity

Lion’s Mane Mushroom consumed orally is well tolerated (please see below for information regarding drug interactions). When used orally and appropriately, it is considered possibly safe for short-term use. The safety of long-term use is not known due to insufficient research and clinical studies. Side effects seem to be limited to mild gastrointestinal discomfort (7).

Toxicity for Lion's Mane in humans has not been established, however, in animal research, the No Observed Adverse Effect Level was greater than 3 grams/kg daily by mouth for 28 days (7).

For further information, please see our References Tab above.


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The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• May provide mood support*
• Supports overall cognitive health*
The following are examples of dynamics associated with Lion’s Mane through the animal model and may not be representative of the effects in the human body:
• May enhance nerve-growth factor*
• May promote healthy blood sugar*
• May promote increased energy levels*

1. Spelman, Kevin, et al. “Neurological Activity of Lion’s Mane (Hericium Erinaceus).” Journal of Restorative Medicne, vol. 6, 2017, doi:DOI 10.14200/jrm.2017.6.0108.
2. Nagano, M, et al. “Reduction…by 4 Weeks Hericium Erinaceus Intake.” Biomed Res., vol. 31, no. 4, Aug. 2010, pp. 231–17.,
3. Mori, K, et al. “Improving Effects of the Mushroom Yamabushitake (Hericium Erinaceus) on Mild Cognitive Impairment: a Double-Blind Placebo-Controlled Clinical Trial.” Phytother Res., vol. 23, no. 3, Mar. 2009, pp. 367–72., doi:doi: 10.1002/ptr.2634.
4. Mori, K, et al. “Nerve Growth Factor-Inducing Activity of Hericium Erinaceus in 1321N1 Human Astrocytoma Cells.” Biol Pharm Bull., vol. 31, no. 9, Sept. 2008, pp. 1727–32.,
5. Liang, B, et al. “Antihyperglycemic and Antihyperlipidemic Activities of Aqueous Extract of Hericium Erinaceus in Experimental Diabetic Rats.” BMC Complement Altern Med, vol. 13, no. 253, Oct. 2013, doi:doi: 10.1186/1472-6882-13-253.
6. Liu, J, et al. “Anti-Fatigue Activities of Polysaccharides Extracted from Hericium Erinaceus.” Exp Ther Med., vol. 9, no. 2, Feb. 2015,
7. “Hericium Erinaceus.” Natural Medicines, Foods, Herbs & Supplements,,-herbs-supplements/professional.aspx?productid=1536#pharmacokinetics.

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Lion's Mane 8:1 Mushroom Extract Capsules

Lion's Mane 8:1 Mushroom Extract Capsules