The benefits of Caffeine + L-theanine are now formulated in our 1-2-GO product to provide all the nootropic benefits of Caffeine, L-theanine and Theobromine.
- (Caffeine + L-Theanine): May improve cognitive performance (ref)*
- (Caffeine + L-Theanine): Promotes benefits of caffeine without unwanted effects (ref)*
- (Caffeine + L-Theanine): Supports focus and attention (ref)*
- (Caffeine + L-Theanine): Promotes wakefulness and alertness (ref)*
- (Caffeine + L-Theanine): L-Theanine is General Recognized As Safe (GRAS) by U.S. FDA (ref)
- (Theobromine): A naturally occurring, mild stimulant responsible for the mood enhancing effects of chocolate (ref)*
1-2-GO Mode of Action
Caffeine and Theobromine are found naturally combined in cocoa, cacao, and chocolate. Caffeine, Theobromine and L-Theanine can all be found in some teas (1).
By combining L-theanine with caffeine, some of the undesirable side of effects of caffeine use is lessened. L-Theanine reduces caffeine’s stimulatory effects without modifying the other mechanisms for focus that caffeine offers. L-Theanine interacts with caffeine by “taking the edge off” and still allows the alertness provided by caffeine to remain (2).
The combination of L-theanine with caffeine also may improve cognitive function (3), may eliminate the blood vessel constriction normally experienced with caffeine (4), and help keep the mind from experiencing wandering, or distraction (5).
The cognitive benefits associated with caffeine in combination with L-Theanine were studied on 50 mg caffeine to 100 mg L-Theanine, so we recommend caffeine to L-Theanine ratio should be 1-part caffeine to 2 parts L-Theanine (6).
Theobromine is a mood-enhancing compound naturally present in chocolate. Theobromine is a mild stimulant that interacts with the dopamine pathways in the brain (7). Theobromine and caffeine are both methylxanthines that stimulate the central nervous system through blocking adenosine receptors (8). In comparison to caffeine, Theobromine is a much weaker stimulant and only exerts about one-tenth of the effects of other methylxanthines (Review Article Health Benefits of Dark Chocolate).
The combination of caffeine and theobromine in chocolate, cocoa, and cacao is linked to the pleasurable effects and appeal of chocolate. Theobromine has also shown promise in promoting blood vessel health (9).
Pure Nootropics’ 1-2-GO provides 390 mg of a proprietary blend of L-Theanine, Theobromine, and Caffeine per 1 capsule. Suggested use for adults is 1 capsule by mouth not more than every 4-6 hours, not to exceed more than 4 capsules in 24 hours.
1-2-GO Side Effects
L-Theanine Side Effects: L-Theanine, regardless of chemical synthesis, biosynthesis, or naturally occurring, is General Recognized As Safe (GRAS) by U.S. FDA.
L-Theanine is very well tolerated and side effects may include headaches and increased sleepiness (10).
Animal research indicates that the No Observed Adverse Effect Level of L-theanine is greater than 4000 mg/kg in rats (10).
(Note: Due to L-Theanine’s effects on reducing blood pressure, possible interactions with pharmaceutical blood pressure medications and herbs/supplements may occur.)Caffeine Side Effects: In moderate doses, caffeine is usually well tolerated in adults and children. Side effects may include insomnia, restlessness, nervousness, nausea, vomiting, gastric irritation, tachycardia, tremors, quickened respiration, convulsions, headache, agitation, anxiety, chest pain, and irregular heartbeat. Large doses of caffeine may cause tachycardia, metabolic acidosis, ketosis, and hyperglycemia. Children and the elderly may experience more adverse effects from caffeine. Chronic use of large amounts of caffeine may cause tolerance, psychological dependence, and abrupt stopping of caffeine use may cause physical withdrawal symptoms (11).
The lethal dose of caffeine in adults is approximately 10-14 grams per kilogram but fatality has also occurred at lower doses (11).
Caffeine has many pharmaceutical medication and herb interactions. If you are taking any medications, herbs, or supplements, please consult your healthcare practitioner before beginning a supplementation with caffeine.
Theobromine Side Effects: Theobromine is toxic to many animals, but in normal consumption it is safe for humans. A standard 40 g dark chocolate bar contains about 250 mg of Theobromine (9). Chocolates with higher cocoa/cacao content have more theobromine than milk chocolate.
Higher doses of 50-100 g of cocoa caused sweating, severe headaches, and trembling (12).
Theobromine is very toxic to dogs because they metabolize it so slowly and they can experience theobromine poisoning (13). Please keep 1-2-GO out of the reach of curious pets.
For further information, please see our References Tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• May improve cognitive performance
Owen, GN, et al. “The Combined Effects of L-Theanine and Caffeine on Cognitive Performance and Mood.” Nutr Neurosci., vol. 11, no. 4, Aug. 2008, pp. 193–8., doi: doi:10.1179/147683008X301513.
• Promotes benefits of caffeine without unwanted effects
Dodd, FL, et al. “A Double-Blind, Placebo-Controlled Study Evaluating the Effects of Caffeine and L-Theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood.” Pyschopharmacology (Berl), vol. 232, no. 14, July 2015, pp. 2563–76., doi:10.1007/s00213-015-3895-0.
• Supports focus and attention
Kahathuduwa, CN, et al. “l-Theanine and Caffeine Improve Target-Specific Attention to Visual Stimuli by Decreasing Mind Wandering: a Human Functional Magnetic Resonance Imaging Study.” Nutr Res., vol. 49, Jan. 2018, pp. 67–78., doi:10.1016/j.nutres.2017.11.002.
• Promotes wakefulness and alertness
Giesbrecht, T, et al. “The Combination of L-Theanine and Caffeine Improves Cognitive Performance and Increases Subjective Alertness.” Nut, vol. 13, no. 6, Dec. 2010, pp. 283–90., doi:10.1179/147683010X12611460764840.
• General Recognized as Safe (GRAS) by U.S. FDA
“GRAS Notices.” U.S. Food & Drug Administration, www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=GrASNotices&sort=Date_of_closure&order=ASC&showAll=true&type=basic&search=theanine.
• A naturally occurring, mild stimulant responsible for the mood enhancing effects of chocolate
Baggott, Matthew J et al. “Psychopharmacology of theobromine in healthy volunteers.” Psychopharmacology vol. 228,1 (2013): 109-18. doi:10.1007/s00213-013-3021-0.
1. IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. Coffee, Tea, Mate, Methylxanthines and Methylglyoxal. Lyon (FR): International Agency for Research on Cancer; 1991. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 51.) Theobromine. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507032/.
2. “Caffeine”. Examine.com, published on Jul 26 2014, Last updated Mar 29, 2019. https://examine.com/supplements/caffeine/.
3. Giesbrecht, T, et al. “The Combination of L-Theanine and Caffeine Improves Cognitive Performance and Increases Subjective Alertness.” Nut, vol. 13, no. 6, Dec. 2010, pp. 283–90., doi:10.1179/147683010X12611460764840.
4. Dodd, FL, et al. “A Double-Blind, Placebo-Controlled Study Evaluating the Effects of Caffeine and L-Theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood.” Pyschopharmacology (Berl), vol. 232, no. 14, July 2015, pp. 2563–76., doi:10.1007/s00213-015-3895-0.
5. Kahathuduwa, CN, et al. “l-Theanine and Caffeine Improve Target-Specific Attention to Visual Stimuli by Decreasing Mind Wandering: a Human Functional Magnetic Resonance Imaging Study.” Nutr Res., vol. 49, Jan. 2018, pp. 67–78., doi:10.1016/j.nutres.2017.11.002.
6. Owen, GN, et al. “The Combined Effects of L-Theanine and Caffeine on Cognitive Performance and Mood.” Nutr Neurosci., vol. 11, no. 4, Aug. 2008, pp. 193–8., doi:doi: 10.1179/147683008X301513.
7. “Where do cravings come from?” Examine.com, published Apr 17, 2017, Last updated Apr 18, 2017. https://examine.com/nutrition/where-do-cravings-come-from/.
8. Franco, R, et al. “Health Benefits of Methylxanthines in Cacao and Chocolate.” Nutrients., vol. 5, no. 10, 18 Oct. 2018, pp. 4159–73., doi:10.3390/nu5104159.
9. Baggott, Matthew J., et al. “Psychopharmacology of Theobromine in Healthy Volunteers.” Psychopharmacology, 31 Jan. 2013, doi:10.1007/s00213-013-3021-0.
10. “Theanine.” Food, Herbs & Supplements, Professional. Natural Medicines, Therapeutic Research, naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1053.
11. “Caffeine.” Food, Herbs & Supplements, Professional. Natural Medicines, Therapeutic Research, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=979#toxicology.
12. “3,7-Dimethylxanthine (Theobromine)”. Toxnet, US National Library of Medicine. 1 December 2017. Retrieved 13 November 2018.
13. “Theobromine.” Wikipedia, en.wikipedia.org/wiki/Theobromine#cite_ref-33.