Glutathione is the most important master antioxidant in the body (1).
- May reduce oxidative stress* (ref)
Glutathione Mode of Action
Glutathione (y-L-Glutamyl-L-cysteinyglycine) is a free radical scavenging antioxidant that is an endogenous in the body (2). It is primarily synthesized in the liver and consists of the amino acids glycine, glutamic acid, and cysteine (3).
Glutathione can be either reduced (GSH) or oxidized (GSSG). The synthesis of glutathione requires two enzymes: one to bind L-cysteine and glutamic acid together and one to add the glycine molecule to the compound to complete the glutathione molecule. It is synthesized within the cell and can be hydrolyzed into the constituent amino acids where it can be resynthesized into glutathione (2).
Together, the enzymes needed for glutathione synthesis and the enzymes which use glutathione are the “glutathione system” (2). Glutathione is an integral part of DNA synthesis and repair, amino acid transport, protein and prostaglandin synthesis, immune system function, prevention of oxidative cell damage, metabolism of toxins and carcinogens, and enzyme activation. Glutathione protects cells against harmful oxidants such as ROS (reactive oxygen species) and can increase the excretion of toxins from cells (3).
Glutathione can be sourced from meats, fruits, and vegetables but dietary intake does not raise levels of glutathione in the body. Cellular glutathione increases during exercise. Glutathione decreases with age (3).
Glutathione Capsules Dosage
Pure Nootropics' Glutathione Capsules provides a complex of 500 mg of Glutathione (Reduced from Setria ®), 100 mg of Milk Thistle Extract target="_blank" (Silybum marianum standardized to 80 mg Silymarin Flavinoids), and 50 mg of Alpha-Lipoic Acid. Suggested use for adults is 1 capsule by mouth on an empty stomach daily, or as directed by your healthcare practitioner.
Glutathione Capsules Side Effects and Toxicity
Glutathione is generally well tolerated, and very few side effects have been noted. Some side effects may include flatulence, loose stools, and flushing (4).
A lethal dose was achieved in mice at a dose of 5 gm/kg (5).
For further information, please see our References Tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• May reduce oxidative stress*
Richie, JP, et al. “Randomized Controlled Trial of Oral Glutathione Supplementation on Body Stores of Glutathione.” Eur J Nutr., vol. 54, no. 2, Mar. 2015, pp. 251–63., doi:10.1007/s00394-014-0706-z.
1. Bains, Vivek Kumar, and Rhythm Bains. “The antioxidant master glutathione and periodontal health.” Dental research journal vol. 12,5 (2015): 389-405.
2. “Glutathione”. Examine.com, published Apr 3, 2014, Last updated Jun 14, 2018. https://examine.com/supplements/glutathione/.
3. “Glutathione”. Foods, Herbs & Supplements. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=717.
4. Allen, Jason, and Ryan D Bradley. “Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers.” Journal of alternative and complementary medicine (New York, N.Y.) vol. 17,9 (2011): 827-33. doi:10.1089/acm.2010.0716.
5. “Glutathione.” PubChem Open Chemistry Database, pubchem.ncbi.nlm.nih.gov/compound/glutathione#section=Acute-Effects.