Uridine (Uridine 5’-monophosphate) is a nucleotide involved in cell membrane health which supports overall brain function (1, 2).
Uridine Monophosphate Benefits
- Supports cellular membrane health (ref)*
Uridine Monophosphate Mode of Action
Uridine (also known as Uridine Monophosphate) is a nucleotide. It is a necessary substrate in the synthesis of choline. The essential nutrient choline is a building block for the neurotransmitter acetylcholine; and to keep your brain transmitting messages at top-notch speed, you’ll want to keep as much acetylcholine in the body as possible! (3,4)
Unlike choline itself, Uridine has a special advantage due to its relationship with cell membranes. Uridine prevents the release of a harmful acid from the membranes. The release of this acid causes oxidative damage, but Uridine prevents this stress from occurring—something your ordinary choline source can’t do! (3)
Having strong cell membranes (the layer of the cell which controls the entry and transport of cellular nutrients) is one of the most important ways to stay healthy. Uridine has an important part in making and maintaining these cell membranes which keep toxins and intruders from entering the cell (3).
We’ve learned a lot about how Uridine increases the level of choline in the body by studying how it works in animals. It’s part of a complex process where it works as a precursor to making the last step in the choline synthesis pathway which delivers choline straight to neurons where it is converted into acetylcholine (6).
Uridine is a key player in the last step of choline synthesis; but unlike choline, you can’t find much in the food you eat. Humans get their Uridine from breast milk, and then it’s synthesized in the liver after weaning occurs (4)(7).
Stack Uridine with the fish oil fatty acid DHA to increase levels of one of acetylcholine’s building blocks (phosphatidylcholine) by 30%! (4)
Uridine Monophosphate Dosage
Pure Nootropics’ Uridine Monophosphate Capsules provide 250 mg per 1 capsule. Suggested use for adults is 1 capsule (or 250 mg powder weighed on a digital milligram scale) by mouth daily, or as recommended by your healthcare practitioner.
If you are taking any medications, please consult with your healthcare practitioner before beginning supplementation with Uridine Monophosphate.
For further information, please see our References Tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• Supports cellular membrane health*
Agarwal, Nivedita et al. “Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T.” Bi… disorders vol. 12,8 (2010): 825-33. doi:10.1111/j.1399-5618.2010.00884.x
1. “Uridine-5′-Monophosphate (Compound).” PubChem Open Chemistry Database, pubchem.ncbi.nlm.nih.gov/compound/Uridylic_acid#section=Literature.
2. Wang, L, et al. “Dietary Uridine-5′-Monophosphate Supplementation Increases Potassium-Evoked Dopamine Release and Promotes Neurite Outgrowth in Aged Rats.” J Mol Neurosci., vol. 27, no. 1, 2005, pp. 137–45., www.ncbi.nlm.nih.gov/pubmed/16055952.
3. Cook, Sarah. “The Unique Benefits of CITICOLINE An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com/sites/default/files/uploads/citicoline.pdf.
4. “Uridine.” Examine.com, published Oct 2, 2014. Last updated Jun 14, 2018. https://examine.com/supplements/uridine/.
5. Linus Pauling Institute. (2019). Choline. Web. https://lpi.oregonstate.edu/mic/other-nutrients/choline.
6. Cansev, Mehmet. “Involvement of Uridine-Nucleotide-Stimulated P2Y Receptors in Neuronal Growth and Function.” Central Nervous System Agents in Medicinal Chemistry(Formerly Current Medicinal Chemistry – Central Nervous System Agents, vol. 7, no. 4, Dec. 2007, pp. 223–229., www.researchgate.net/figure/Fig-2-Kennedy-pathway-of-PC-synthesis_fig1_233682182.
7. Wurtman, Richard J. “A nutrient combination that can affect synapse formation.” Nutrients vol. 6,4 1701-10. 23 Apr. 2014, doi:10.3390/nu6041701.
8. “Uridine 5′-Triphosphate.” Drugbank, www.drugbank.ca/drugs/DB04005.
9. Blusztajn, JK, et al. “Phosphatidylcholine as a Precursor of Choline for Acetylcholine Synthesis.” J Neural Transm Suppl, vol. 24, 1987, pp. 247–59., www.ncbi.nlm.nih.gov/pubmed/3316498.
10. Agarwal, Nivedita et al. “Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T.” Bi… disorders vol. 12,8 (2010): 825-33. doi:10.1111/j.1399-5618.2010.00884.x