Vinpocetine is an alkaloid that is synthetically derived from the compound found in periwinkle plants, vincamine (1).
- May improve memory (ref)*
- Supports cognition during age-related cognitive decline (ref)(ref)*
- Mood support (ref)*
Vinpocetine Mode of Action
Vinpocetine’s cognitive and memory benefits may be related to its ability to increase blood circulation in the brain, decrease the rate of neuronal death, improve intracerebral glucose, and produce long-term potentiation in the hippocampus (2). Memory improvement is also believed to be from inhibition of sodium and calcium channels and modulating noradrenergic activity in the brain (1).
Vinpocetine is believed to inhibit platelet aggregation and is therefore not recommended for those with bleeding disorders, or blood-clotting disorders because it may increase the risk of bleeding. Other functions involving blood flow is improved red blood cell formation and improving microcirculation in the brain, leading to increased cerebral blood flow. It may also protect neurons by preventing a loss of oxygen, due to the increased amount of red blood cells carrying oxygen that is available to the brain (2).
The nootropic benefits of Vinpocetine may be caused by cholinergic activity, modulation of norepinephrine effects on cyclic adenosine monophosphate (cAMP, a messenger in the signal transduction pathways), and increased brain catecholamines (2, 3).
Vinpocetine's bioavailability is significantly increased by taking it with a meal and raises the absorption rate up to 60-100% (2).
Pure Nootropics’ Vinpocetine provides 20 mg of Vinpocetine (extract from the whole periwinkle plant) per 1 capsule. Suggested use for adults is 1 to 2 capsules by mouth daily, or as directed by your healthcare practitioner.
Vinpocetine Side Effects and Toxicity
As of 6/3/19, the US FDA concludes that Vinpocetine should not be taken by women who are pregnant, or can become pregnant.
Vinpocetine is usually well tolerated. Side effects may include stomach discomfort, anxiety, vertigo, nausea, sleep disturbances, facial flushing, and headache (2).
If you are taking any medications, please consult your healthcare practitioner before beginning supplementation with Vinpocetine (2).
For further information, please see our References Tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• May improve memory*
Subhan, Z, and I Hindmarch. “Psychopharmacological Effects of Vinpocetine in Normal Healthy Volunteers.” Eur J Clin Pharmacol, vol. 28, no. 5, 1985, pp. 567–71., www.ncbi.nlm.nih.gov/pubmed/3899677.
• Supports cognition during age-related cognitive decline*
Valikovics, A, et al. “[Study of the Effects of Vinpocetin on Cognitive Functions].” Ideggyogy Sz, vol. 65, no. 3-4, 30 Mar. 2012, pp. 115–20., www.ncbi.nlm.nih.gov/pubmed/23136730.
Hindmarch, I, et al. “Efficacy and Tolerance of Vinpocetine in Ambulant Patients Suffering from Mild to Moderate Organic Psychosyndromes.” Int Clin Pyschopharmacol, vol. 6, no. 1, 1994, pp. 31–43., www.ncbi.nlm.nih.gov/pubmed/2071888/.
• Mood support*
Vorob’eva, OV, and ES Tamarova. “[Efficacy of Vinpotropile in the Therapy of Initial Signs of Cerebrovascular Pathology].” Zh Nevrol Psikhiatr Im S S Korsakova, vol. 110, no. 9, 2010, pp. 39–42., www.ncbi.nlm.nih.gov/pubmed/21183904.
1. “Vinpocetine”. Examine.com. https://examine.com/supplements/vinpocetine/.
2. “Vinpocetine.” Foods, Herbs & Supplements. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=175.
3. “Cyclic adenosine monophosphate”. Wikipedia. https://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate.