Theacrine (TeaCrine®) Capsules

Product Description

Theacrine (1,3,7,9-tetramethyluric acid) is found in some coffee species and tea, most notably kucha (Camellia assamica) (1). 

TeaCrine® is a registered trademark and protected by Patents Pending, Serial No. 61/903,362; under exclusive global distribution by Compound Solutions, Inc.

Theacrine (TeaCrine®) Capsules Benefits

• May enhance energy, focus, and concentration (ref)*
• Non-habit-forming source of energy (ref)*
• GRAS (Generally Recognized as Safe) (ref)*
• Combined with caffeine, supports cognitive function (ref)*
• Combine with caffeine for greater bioavailability (ref)*

Theacrine (TeaCrine®) Capsules Mode of Action

TeaCrine® is a chemically equivalent version of theacrine (1).  Theacrine is an alkaloid molecule closely related to caffeine but structurally different.  The most abundant source of theacrine known at this time is from Kucha tea leaves (2).

The difference between theacrine and caffeine molecules is an additional methyl group and ketone group.  Like caffeine, theacrine causes signaling changes on adenosine receptors and may influence dopaminergic signaling in a similar manner to caffeine (2).

Kucha tea is a Chinese tea containing two major alkaloids, caffeine and theacrine.  Concentrations of both alkaloids are higher in younger leaves and buds and lower in mature leaves.  Research suggests that theacrine is synthesized from adenosine through caffeine in a three-step pathway within the kucha leaves (3).

Unlike caffeine, no adverse effects or changes in blood pressure or heart rate occur in animal studies (4).  Even when combined with caffeine, no differences in heart rate or blood pressure were noted in human trials (5).  In a clinical human study, all values for clinical safety markers (such as blood pressure, heart rate, lipid profiles, biomarkers of liver, kidney, and immune function, and hematologic blood counts) were normal throughout the 8-week study (1).

TeaCrine® was found to be non-habituating, unlike caffeine (1).

Theacrine (TeaCrine®) Capsules Dosage

Theacrine (TeaCrine®) Capsules provide 100 mg of Theacrine (as TeaCrine®) per 1 capsule.  Suggested use for adults is 1 capsule by mouth daily, or as directed by your healthcare practitioner.

If you are taking any medications, always consult with you Healthcare Practitioner before beginning any new supplement.

Theacrine (TeaCrine®) Capsules Side Effects and Toxicity

Theacrine (TeaCrine®) is considered GRAS by the U.S. FDA (Generally Recognized As Safe).

The lethal dose for mice was achieved at 810.6 mg/kg which equates to 4 g per a 76 kg human (4).

For further information, please see our References Tab above.

THEACRINE CERTIFICATE OF ANALYSIS 04/2017

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• May enhance energy, focus, and concentration*
Ziegenfuss, TN, et al. “A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters.” J Diet Suppl, vol. 14, no. 1, 2 Jan. 2017, pp. 9–24., doi:10.1080/19390211.2016.1178678.
• Non-habit-forming source of energy *
Taylor, L, et al. “Safety of TeaCrine®, a Non-Habituating, Naturally-Occurring Purine Alkaloid over Eight Weeks of Continuous Use.” J Int Soc Sports Nutr, vol. 13, no. 2, 13 Jan. 2016, doi:10.1186/s12970-016-0113-3.
• GRAS (Generally Recognized as Safe by US FDA)*
“Teacrine.” Compound Solutions, www.compoundsolutions.com/science.html.
• Combined with caffeine, supports cognitive function*
Bello, ML, et al. “The Effects of TeaCrine® and Caffeine on Endurance and Cognitive Performance during a Simulated Match in High-Level Soccer Players.” J Int Soc Sports Nutr, vol. 16, no. 1, 18 Apr. 2019. Compound Solutions, doi:10.1186/s12970-019-0287-6.
• Combine with caffeine for greater bioavailability*
He, Hui et al. “Assessment of the Drug-Drug Interaction Potential Between Theacrine and Caffeine in Humans.” Journal of caffeine research vol. 7,3 (2017): 95-102. doi:10.1089/jcr.2017.0006

1. Taylor, L, et al. “Safety of TeaCrine®, a Non-Habituating, Naturally-Occurring Purine Alkaloid over Eight Weeks of Continuous Use.” J Int Soc Sports Nutr, vol. 13, no. 2, 13 Jan. 2016, doi:10.1186/s12970-016-0113-3.
2. “Theacrine.” Examine.com, published Nov 20, 2013. Last updated Jun 14, 2018. https://examine.com/supplements/theacrine/.
3. Zheng, XQ, et al. “Theacrine (1,3,7,9-Tetramethyluric Acid) Synthesis in Leaves of a Chinese Tea, Kucha (Camellia Assamica Var. Kucha).” Phytochemistry, vol. 60, no. 2, May 2002, pp. 129–34., www.ncbi.nlm.nih.gov/pubmed/12009315.
4. Taylor, Lem et al. “Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use.” Journal of the International Society of Sports Nutrition vol. 13 2. 13 Jan. 2016, doi:10.1186/s12970-016-0113-3.
5. He, Hui et al. “Assessment of the Drug-Drug Interaction Potential Between Theacrine and Caffeine in Humans.” Journal of caffeine research vol. 7,3 (2017): 95-102. doi:10.1089/jcr.2017.0006