Theacrine (1,3,7,9-tetramethyluric acid) is found in some coffee species and tea, most notably kucha (Camellia assamica) (1).
TeaCrine® is a registered trademark and protected by Patents Pending, Serial No. 61/903,362; under exclusive global distribution by Compound Solutions, Inc.
Theacrine (TeaCrine®) Capsules Benefits
- May enhance energy, focus, and concentration (ref)*
- Non-habit-forming source of energy (ref)*
- GRAS (Generally Recognized as Safe) (ref)*
- Combined with caffeine, supports cognitive function (ref)*
- Combine with caffeine for greater bioavailability (ref)*
Theacrine (TeaCrine®) Capsules Mode of Action
TeaCrine® is a chemically equivalent version of theacrine (1). Theacrine is an alkaloid molecule closely related to caffeine but structurally different. The most abundant source of theacrine known at this time is from Kucha tea leaves (2).
The difference between theacrine and caffeine molecules is an additional methyl group and ketone group. Like caffeine, theacrine causes signaling changes on adenosine receptors and may influence dopaminergic signaling in a similar manner to caffeine (2).
Kucha tea is a Chinese tea containing two major alkaloids, caffeine and theacrine. Concentrations of both alkaloids are higher in younger leaves and buds and lower in mature leaves. Research suggests that theacrine is synthesized from adenosine through caffeine in a three-step pathway within the kucha leaves (3).
Unlike caffeine, no adverse effects or changes in blood pressure or heart rate occur in animal studies (4). Even when combined with caffeine, no differences in heart rate or blood pressure were noted in human trials (5). In a clinical human study, all values for clinical safety markers (such as blood pressure, heart rate, lipid profiles, biomarkers of liver, kidney, and immune function, and hematologic blood counts) were normal throughout the 8-week study (1).
TeaCrine® was found to be non-habituating, unlike caffeine (1).
Theacrine (TeaCrine®) Capsules Dosage
Theacrine (TeaCrine®) Capsules provide 100 mg of Theacrine (as TeaCrine®) per 1 capsule. Suggested use for adults is 1 capsule by mouth daily, or as directed by your healthcare practitioner.
If you are taking any medications, always consult with you Healthcare Practitioner before beginning any new supplement.
Theacrine (TeaCrine®) Capsules Side Effects and Toxicity
Theacrine (TeaCrine®) is considered GRAS by the U.S. FDA (Generally Recognized As Safe).
The lethal dose for mice was achieved at 810.6 mg/kg which equates to 4 g per a 76 kg human (4).
For further information, please see our References Tab above.