Sulbutiamine Capsules


Sulbutiamine is a synthetic version of Vitamin B1 (Thiamine) that was designed to cross the blood brain barrier more easily than its derived counterpart and used for improved cognitive abilities and mood.

  • Used to improve mood & focus (reference)
  • Stimulant like properties to reduce fatigue (ref)
  • Improves mental performance and memory (ref)
  • Promotes wakefulness (ref)

Third Party Certificate (CoA) for Sulbutamine – 05/2017


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Mild brain stimulant derived from Vitamin B1 ( Thiamine ). Sulbutiamine promotes wakefulness, elevates mood, and often used to treat fatigue; athletes like sulbutiamine for its stimulant properties. Sulbutiamine was designed to cross the blood brain barrier more readily than Thiamine. In fact, it is 2.4 times more effective at crossing the blood-brain barrier. Sulbutiamine is sometimes prescribed (under the brand name Arcalion) to treat Asthenia (ref).

Synthesized in 1936, the drug was used for Japanese naval soldiers traveling across the seas. Thiamine can help to increase cognitive function and reduce fatigue related to deficiency. Beyond reducing fatigue, it is a powerful neuroprotective agent. Nutrient deficiencies with thiamine lead to a disruption of synaptic transmission, which sulbutiamine can solve.

Finally, it seems there are sulbutiamine benefits related to memory retention and mental performance. One study showed object-recognition memory improvements in patients using sulbutiamine.


Every individual reacts differently to Sulbutiamine, but the most common dosage is 200mg twice a day and is the recommended amount on the prescribed version (Arcalion). Studies that utilized Sulbutiamine used doses of up to 600mg.

The manufacturer of the branded version of Sulbutiamine suggests no more than 600mg/day should be taken to avoid adverse effects. Sulbutiamine is lipid soluble but can be taken with water. Anecdotal reports generally indicate that the efficacy of Sulbutiamine diminishes over time and thus should be cycled. Because of its stimulant like properties, Sulbutiamine should be avoided in the evenings.


Sulbutiamine is often compared to Thiamine which has little side effects at therapeutic doses.  In humans, doses of 400mg per day resulted in few health problems, with a mild skin allergy being the most common and agitation in the elderly. Some users report negative side effects including headaches, irritation, dermatitis. Sulbutiamine has been shown to negatively interact with bipolar treatments and should not be taken along with other substances used in the treatment of bipolar disorder.


If you buy Sulbutiamine online from Pure Nootropics, expect arrival within the continental U.S. between 5 – 7 days, unless shipping is upgraded to priority or express.

Additional information

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60 x 200mg Capsules, 40g (Powder Only)

Full Analysis

Sulbutiamine is a synthetic molecule derived from thiamine (vitamin B1), which is used to treat chronic fatigue, boost concentration, and improve memory retention.

  • Sulbutiamine provides neurological protection to brain cells (reference)
  • Improves choline uptake by 10.1% to improve memory retention (ref)
  • Reduces mental and physical fatigue to work longer and harder (ref)
  • Improves mental energy by 51.7 – 74.13% (ref) (ref)

Sulbutiamine Benefits

First synthesized by Japanese scientists in the 1960s, sulbutiamine was one of the most important tools for fighting beriberi. Japanese sailors were contracting this disease as early as the 1930s when sailing across the globe and it wasn’t long before they realized their problem: a deficiency in thiamine (vitamin B1).

After decades of research, sulbutiamine was born as the way to improve vitamin B1 levels and boost this essential vitamin for brain health. The benefits of sulbutiamine include reduced fatigue and mental stress levels. Most of the time, this is a result of nutrient deficiency (namely thiamine). Because our diets rarely look as ideal as we would like, it is a common problem to have.

One of the main advantages of sulbutiamine is that it can cross the blood-brain barrier incredibly efficiently compared to thiamine. In fact, it is almost 2 times more effective at crossing the blood brain barrier, making it more efficient than taking a simple thiamine supplement!

Sulbutiamine Studies 

The evidence on sulbutiamine is far from conclusive, but there is ample evidence to suggest significant benefits. One of the main studies was whether sulbutiamine increased the vitamin B1 levels within the brain and if this allowed brain cells to communicate more readily. The communication between cells is thought to increase some memory and learning ability in addition to energy.

Other studies on the subject note that sulbutiamine crosses the blood brain barrier relatively well, which is in contrast to some of the other options that are used to increase thiamine levels.

Sulbutiamine Side Effects

There are many potential nootropics to choose from and obviously you want to take the one with the least likelihood of causing side effects. Luckily, sulbutiamine works by providing more of an essential nutrient into your blood stream and brain. This means the side effects of sulbutiamine aren’t probably all that dangerous.

Of course, too much of a good thing can be a bad thing. Taking too high a quantity can lead to anxiety, sweating, and tension. Make sure you take the recommended dosage instead of too high a quantity.

Buy Sulbutiamine

There are many options for sulbutiamine online, but you want to get the safest product. Although we are piased, Pure Nootropics has sulbutiamine and a number of other nootropics with third party certificates of analysis. This kind of attention to detail allows our customers to have peace of mind and feel safer about the entire process.


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