Mild brain stimulant derived from Vitamin B1 ( Thiamine ). Sulbutiamine promotes wakefulness, elevates mood, and often used to treat fatigue; athletes like sulbutiamine for its stimulant properties. Sulbutiamine was designed to cross the blood brain barrier more readily than Thiamine. In fact, it is 2.4 times more effective at crossing the blood-brain barrier. Sulbutiamine is sometimes prescribed (under the brand name Arcalion) to treat Asthenia (ref).
Synthesized in 1936, the drug was used for Japanese naval soldiers traveling across the seas. Thiamine can help to increase cognitive function and reduce fatigue related to deficiency. Beyond reducing fatigue, it is a powerful neuroprotective agent. Nutrient deficiencies with thiamine lead to a disruption of synaptic transmission, which sulbutiamine can solve.
Finally, it seems there are sulbutiamine benefits related to memory retention and mental performance. One study showed object-recognition memory improvements in patients using sulbutiamine.
Every individual reacts differently to Sulbutiamine, but the most common dosage is 200mg twice a day and is the recommended amount on the prescribed version (Arcalion). Studies that utilized Sulbutiamine used doses of up to 600mg.
The manufacturer of the branded version of Sulbutiamine suggests no more than 600mg/day should be taken to avoid adverse effects. Sulbutiamine is lipid soluble but can be taken with water. Anecdotal reports generally indicate that the efficacy of Sulbutiamine diminishes over time and thus should be cycled. Because of its stimulant like properties, Sulbutiamine should be avoided in the evenings.
Sulbutiamine is often compared to Thiamine which has little side effects at therapeutic doses. In humans, doses of 400mg per day resulted in few health problems, with a mild skin allergy being the most common and agitation in the elderly. Some users report negative side effects including headaches, irritation, dermatitis. Sulbutiamine has been shown to negatively interact with bipolar treatments and should not be taken along with other substances used in the treatment of bipolar disorder.
If you buy Sulbutiamine online from Pure Nootropics, expect arrival within the continental U.S. between 5 – 7 days, unless shipping is upgraded to priority or express.