optimal choline complex supplement facts

Optimal Choline Complex

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Pure Nootropics’ Optimal Choline Complex combines two products to provide superior results. The two main ingredients are CDP Choline and Alpha GPC Choline.

Some benefits of CDP Choline include:

Supports cognitive function in the elderly (ref)*
May improve attentional performance (ref)(ref)*
May limit excitotoxicity from glutamate activity (ref)*
Promotes an increase in brain energy through improved mitochondrial functions (ref)*

Some benefits of Alpha GPC include:

Supports cognitive function in the elderly with high doses more significantly than CDP Choline (ref)*
May increase the production of the human growth hormone (HGH or somatropin) by working with the pituitary gland(ref)*
Promotes increases in strength outputs during resistance training workouts (ref)*
May enhance lower body muscle performance (ref)*
May provide a steadier level of choline in the body than with CDP Choline (ref)*

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Product Description

Pure Nootropics’ Optimal Choline Complex combines two products to provide superior results. The two main ingredients are CDP Choline and Alpha GPC Choline. Both CDP Choline and Alpha GPC are essential nutrients which are precursors to acetylcholine. Acetylcholine is a neurotransmitter in the parts of the brain that impact memory and learning, attention, and alertness–making it one of the most beneficial neurotransmitter compounds for overall cognitive function and brain health (1).

Optimal Choline Complex Benefits

1) CDP Choline (also known as citicoline) is an essential nutrient and precursor to creating the neurotransmitter acetylcholine (1).

Some benefits of CDP Choline include:

Supports cognitive function in the elderly (ref)*
May improve attentional performance (ref)(ref)*
May limit excitotoxicity from glutamate activity (ref)*
Promotes an increase in brain energy through improved mitochondrial functions (ref)*

2) Alpha GPC Choline, an abbreviation for Alpha-glycerylphosphorylcholine, is also a cholinergic compound found in the brain and a precursor to creating acetylcholine, functioning similarly to CDP Choline in acetylcholine synthesis. Alpha GPC provides some additional advantages by increasing acetylcholine in the central nervous system and seems to be the more efficient choline precursor because of its bioavailability (2).

Some benefits of Alpha GPC include:

Supports cognitive function in the elderly with high doses more significantly than CDP Choline (ref)*
May increase the production of the human growth hormone (HGH or somatropin) by working with the pituitary gland(ref)*
Promotes increases in strength outputs during resistance training workouts (ref)*
May enhance lower body muscle performance (ref)*
May provide a steadier level of choline in the body than with CDP Choline (ref)*

Optimal Choline Complex Mode of Action

Citicoline and Alpha GPC are both involved as acetylcholine precursors. Both cholinergics combine to provide superior cognitive support in Optimal Choline Complex.

Citicoline can be produced from choline already present in the body, but choline’s ability to engage in cell membrane formation (phospholipid synthesis) is incomplete without first being converted to Citicoline. This constant demand for choline conversion to citicoline can mean that supplementing with Citicoline itself provides a boost for overall cell functioning (1).

Choline supports memory and cognitive function and can possibly maintain overall wellness in the brain when faced with cognitive decline (2). CDP Choline may improve attentional performance and focus (3,4). While CDP Choline is found in dietary sources such as animal-based products, eggs, whole grains, cruciferous vegetables, nuts and seeds, most people don’t get an adequate intake of choline in their diet (1).

Being a choline, Alpha GPC is found in many of the same dietary sources that contain CDP Choline (animal-based products, eggs, whole grains, cruciferous vegetables, nuts, and seeds) and is also a nutrient that is difficult to reach an adequate level from diet alone (1).

By working directly with the pituitary gland, Alpha GPC may increase the production of the human growth hormone (2). Preliminary trials relating to Alpha GPC administered to healthy volunteers prior to resistance exercise have shown promise in possibly increasing strength output during workouts, presumably due to its influence on HGH (4).

A clinical trial of Alpha GPC demonstrated that it may enhance lower body muscle performance related to isometric exercise (5).

Being a highly available form of choline, Alpha GPC may provide a steadier level in the body than supplementation with CDP (Citicoline). Levels increase slowly but remain elevated longer than with Citicoline in clinical trials (6).

Optimal Choline Complex Dosage

Pure Nootropics’ Optimal Choline Complex capsules provide 200 mg of Citicoline and 100 mg of Alpha GPC. Suggested use of Optimal Choline Complex capsules for adults is 1 capsule by mouth up to two times per day, with or without food, or as directed by your healthcare practitioner.

No daily value has been established for Alpha GPC or CDP (citicoline). However, RDA (Recommended Daily Allowance) of Choline ranges depending on gender and age. *

RDA for Choline for adult men over 18 is 550 mg/day (11)
RDA for Choline for adult women is 400-425 mg/day (11)

(Women who are pregnant, lactating, and children under the age of 18 should seek medical advice from a healthcare provider regarding their RDA of Choline.)

Optimal Choline Complex Side Effects and Toxicity

Side effects from short-term use of Citicoline are generally mild. Studies conducted have mostly been on a short-term basis, and as such, the safety of long-term use is not known. It is generally well-tolerated, but as with all supplements and medications, some people may experience side effects. It is considered possibly safe and side effects could include bradycardia, tachycardia, vomiting, nausea, or hypotension (7)(13). Note: There may be pharmaceutical medications which interact with Citicoline and should not be taken together. Please consult your healthcare practitioner if you are taking any medications prior to beginning supplementation with Citicoline. Do not use if you are pregnant or nursing.

In both preclinical toxicological studies and clinical studies, research shows that toxicity derived from Citicoline is extremely difficult to achieve (8).

As with Citicoline, the safety of long-term use of Alpha GPC is not known. It is generally well-tolerated, but as with all supplements and medications, some people may experience side effects. It is considered possibly safe and side effects from Alpha GPC are mild and could include heartburn, nausea, vomiting, insomnia or excitation, and headache (9,10).

Toxicity information for Alpha GPC has been extrapolated from animal studies and demonstrates that the “No Observed Adverse Effect Level” (NOAEL) for humans was for a dose at least 150 mg/kg over a six-and-half month timespan (12).

For further information, please see our References Tab above.

Additional Information

Weight	0.11875 lbs
Dimensions	1.95 × 1.95 × 3.95 in

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human conditionWe encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• Supports cognitive function in elderly and those with age related cognitive decline*
Di Trapani, G, and M Fioravanti. “Citicoline in the Treatment of Cognitive and Behavioral Disorders in Pathologic Senile Decline.” Clin Ter, vol. 137, no. 6, 30 June 1991, pp. 403–13., www.ncbi.nlm.nih.gov/pubmed/1832612.

• May improve attentional performance*
McGlade, E, et al. “The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.” J Atten Disord, vol. 23, no. 2, Jan. 2019, pp. 121–134., doi:10.1177/1087054715593633. https://www.ncbi.nlm.nih.gov/pubmed/26179181.

McGlade, E, et al. “Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women.” Food and Nutrition Sciences, no. 3, June 2012, pp. 769–773., doi:10.4236/fns.2012.36103. https://cognizin.com/uploads/pdfs/improve-attention-cognizin.pdf.

• May limit excitotoxicity from glutamate activity*
Cook, Sarah. “The Unique Benefits of CITICOLINE An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com/sites/default/files/uploads/citicoline.pdf.

• Promotes an increase in brain energy through improved mitochondrial function *
Cook, Sarah. “The Unique Benefits of CITICOLINE An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com/sites/default/files/uploads/citicoline.pdf.

• Supports cognitive function in the elderly with age related cognitive decline more significantly
than CDP Choline*
Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.

• May increase the production of the human growth hormone (HGH or somatropin) by working with
pituitary gland*
Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.

• Promotes increases in strength outputs during resistance training workouts*
Ziegenfuss, Tim, et al. “Acute Supplementation with Alpha-Glycerylphosphorylcholine Augments Growth Hormone Response to, and Peak Force Production during, Resistance Exercise.” Journal of the International Society of Sports Nutrition, vol. 5, no. Suppl 1, 17 Sept. 2008, p. 15., jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15.

• May enhance lower body muscle performance*
Bellar, David et al. “The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength” Journal of the International Society of Sports Nutrition vol. 12 42. 17 Nov. 2015, doi:10.1186/s12970-015-0103-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650143/.

• May provide a steadier level of choline in the body than with CDP Choline *
Gatti, G, et al. “A Comparative Study of Free Plasma Choline Levels Following Intramuscular Administration of L-Alpha-Glycerylphosphorylcholine and Citicoline in Normal Volunteers.” Int J Clin Pharmacol Ther Toxicol., vol. 30, no. 9, Sept. 1992, pp. 331–5., www.ncbi.nlm.nih.gov/pubmed/1428296?dopt=Abstract.

1. Cook, Sarah. “The Unique Benefits of CITICOLINE An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com/sites/default/files/uploads/citicoline.pdf.
2. Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.
3. McGlade, E, et al. “The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.” J Atten Disord, vol. 23, no. 2, Jan. 2019, pp. 121–134., doi:10.1177/1087054715593633. https://www.ncbi.nlm.nih.gov/pubmed/26179181.
McGlade, E, et al. “Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women.” Food and Nutrition Sciences, no. 3, June 2012, pp. 769–773., doi:10.4236/fns.2012.36103. https://cognizin.com/uploads/pdfs/improve-attention-cognizin.pdf.
4. Ziegenfuss, Tim, et al. “Acute Supplementation with Alpha-Glycerylphosphorylcholine Augments Growth Hormone Response to, and Peak Force Production during, Resistance Exercise.” Journal of the International Society of Sports Nutrition, vol. 5, no. Suppl 1, 17 Sept. 2008, p. 15., jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15.
5. Bellar, David et al. “The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength” Journal of the International Society of Sports Nutrition vol. 12 42. 17 Nov. 2015, doi:10.1186/s12970-015-0103-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650143/.
6. Gatti, G, et al. “A Comparative Study of Free Plasma Choline Levels Following Intramuscular Administration of L-Alpha-Glycerylphosphorylcholine and Citicoline in Normal Volunteers.” Int J Clin Pharmacol Ther Toxicol., vol. 30, no. 9, Sept. 1992, pp. 331–5., www.ncbi.nlm.nih.gov/pubmed/1428296?dopt=Abstract.
7. Secades, JJ, and JL Lorenzo. “Citicoline: Pharmacological and Clinical Review, 2006 Update.” Methods Find Exp Clin Pharmacol, vol. 28, no. Suppl B, 2006, pp. 1–56., www.ncbi.nlm.nih.gov/pubmed/17171187.
8. Grieb, Pawel. “Neuroprotective properties of citicoline: facts, doubts and unresolved issues” CNS drugs vol. 28,3 (2014): 185-93. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933742/.
9. Barbagallo Sangiorgi, G, et al. “Alpha-Glycerophosphocholine in the Mental Recovery of Cerebral Ischemic Attacks. An Italian Multicenter Clinical Trial.” Ann N Y Acad Sci., vol. 717, 30 June 1994, pp. 253–69., www.ncbi.nlm.nih.gov/pubmed/8030842?dopt=Abstract.
10. “Alpha-GPC.” Food, Herbs & Supplements, Professional, naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1087#safety.
11. “Choline Fact Sheet for Health Professionals.” National Institutes of Health Office of Dietary Supplements, ods.od.nih.gov/factsheets/Choline-HealthProfessional/#h2.
12. Brownawell, AM, et al. “Safety Assessment of AGPC as a Food Ingredient.” Food Chem Toxicol., vol. 49, no. 6, June 2011, pp. 1303–15., doi: 10.1016/j.fct.2011.03.012.
13. “Citicoline.” Foods Herbs & Supplements, Professional, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1090#adverseEvents.

12 reviews for Optimal Choline Complex

Rated 5 out of 5

Ross (verified owner) – September 12, 2014

Without a doubt, boosting acetylcholine levels is the first step when beginning a nootropics stack or regimen. This is a great product and I highly recommend seeing the benefits it can provide for yourself. This being a blend of two of the more/most bioavailable forms, this is a good choline supplement to start on.
I would like to see more options on blend ratios, but offering both in one supplement is a highly effective format.
Rated 5 out of 5

Christopher (verified owner) – May 11, 2015

Pure Nootropics’ Optimal Choline Complex is a product I’ve been searching for for quite some time at various nootropic retail Websites. It’ priced well for the highly effecttlve balance of Choline types supplied nicely in a bottle of (green) capsules. Again, amazing product and works extremely well, and synergistically when taken with the racetams. Another top rate product from Pure Nootropics. This type of choli e, as opposed to Choline Bitartrate, especially is great. I’ve just ordered more, in fact, for the fourth time in a row.
Rated 5 out of 5

Tom Twist – June 25, 2018

It is amazing how it works.. Its awesome.
Rated 5 out of 5

Myles (verified owner) – August 11, 2019

I had started getting headaches after using the various racetam supplements (Py/Oxi/phenyl). My prefered use of the racetam’s is just taking one in the morning before a large day of studying with a good nights sleep. As far as this product is concerned, I’ve found that a 1:2 racetam to choline ratio has abolished my headaches. To my knowledge its well priced and I believe is a must buy if you are considering using racetam’s long term.
Rated 5 out of 5

Jacob G. (verified owner) – August 12, 2019

With this supplement, my brain got much sharper, recalling distant and recent details I had long fuzzied.
Rated 5 out of 5

Amber H. (verified owner) – August 12, 2019

Great for focus and ADD
Rated 5 out of 5

Denise G. (verified owner) – August 12, 2019

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Rated 5 out of 5

Richard G. (verified owner) – August 12, 2019

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Rated 5 out of 5

Sho V. (verified owner) – August 12, 2019

Imagine having CDP Choline and Alpha GPC both in one. Take it and combine it with any type of other stacks and you have your daily doses of Choline. Best combination is to combine it with Modalert.
Rated 5 out of 5

Jeffrey A. (verified owner) – August 12, 2019

Excellent product
Rated 5 out of 5

billy s. (verified owner) – August 12, 2019

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Rated 5 out of 5

Harold W. (verified owner) – August 12, 2019

I have been using Optimal Choline Complex for a few months now, very, pleased with your products.I’m here because of Mansal Denton.Thank You.