Optimal Choline Complex

5.00 out of 5 based on 2 customer ratings
(2 customer reviews)


This formula offers memory enhancement and neuro protective benefits of the two most efficient choline sources: CDP choline and alpha GPC choline

  • Cognitive/memory enhancement (reference)(ref)
  • Improves cognitive impairment (ref)
  • Memory/brain protection (ref)(ref)
  • Increased cerebral blood flow (ref)
  • All ingredients recognized as safe by FDA (ref)

60 x 300mg vegetarian capsules

CHOLINE Certificate of Analysis 05/2017

In stock



There are many benefits of the Optimal Choline Complex that go beyond acetylcholine synthesis. While the two main ingredients, CDP choline and alpha GPC choline, provide adequate acetylcholine support, there are other advantages of using these prodrugs. CDP choline (aka citicholine) is known to improve focus and attention in students with learning disabilities or ADD. For people that do not consume enough eggs or organ meats, CDP choline and alpha GPC choline both prevent memory impairment and neurological degradation common in Alzheimer’s patients and those with senile dementia.

CDP choline can improve cerebral blood flow to the brain and can decrease the accumulation of lactate and glutamate, which are both implicated in neuro degeneration. CDP choline is also unique in that it aids the reconstruction of membrane phospholipid stores, which are often depleted. CDP choline also creates uridine in the body, which is a neuro protective agent similar to choline.

Alpha GPC works on many of the same mechanisms as citicholine, but has additional advantages. Studies show 14% power output in strength athletes as well as higher human growth hormone secretion. More importantly, alpha GPC can potentiate the effects of an acetylcholinesterase inhibitor and promotes long-term potentiation.


The dosage is dependent upon the individual, but the Optimal Choline Complex dosage is one 300mg capsule. This includes 200mg of CDP choline and 100mg of alpha GPC choline. Take this dosage in the morning and at night for optimal results. One can take more than a single 300mg capsule at one time, but it may not provide optimal results. Test the efficacy of dosages for your own needs.

Mode of Action

Both citicholine and alpha GPC choline provide the body with choline, which is required to create the neurotransmitter acetylcholine. This neurotransmitter is involved with many functions including memory formation and retention. The Optimal Choline Complex utilizes the separate modes of action from both of these sources to provide the most significant cognitive effects.


The toxicity studies on both citicholine and alpha GPC choline show they are relatively safe supplements for human consumption. Both are Generally Recognized As Safe (GRAS) by the United States Food & Drug Administration for branded versions of the particular compounds. Studies of alpha GPC show that the LD50 is 10,000mg/kg in rats/mice. A standardized label of “no observed adverse effect level” (NOAEL) was given to the dose of 1,000mg/kg, which equates to around 1640mg for a 150 lb. individual. It is not recommended to consume more than 2-3 capsules of the Choline Complex per day.

Additional information

Weight 0.11875 lbs
Dimensions 1.95 x 1.95 x 3.95 in

Full Analysis

The Optimal Choline Complex combines citicoline and Alpha GPC, which both help with learning, memory, and is widely used for neuro protective capabilities.

  • Enhances memory and learning (reference)
  • Potent stimulant (ref)
  • Protects against brain damage (ref)
  • Used to treat Alzheimer’s / aged related memory loss (ref)

Benefits of Optimal Choline Complex

The main benefits of the Optimal Choline Complex are to increase acetylcholine in the brain. The way this complex achieves this is through two of the most bioavailable and effective choline sources that you can purchase via supplements. The choline complex is a combination of the aforementioned citicoline (also known as CDP choline) and alpha GPC choline. Both have unique benefits of there own, which aid in cognition and neuroprotection.

Studies of Choline

There are four main neurotransmitters (brain chemicals) responsible for maintaining a healthy brain. One of these is called acetylcholine and it is the one primarily reserved for memory formation and learning abilities. By providing the body with more raw choline, it can convert that into acetylcholine and help form memories, protect neurological connections and prevent memory loss.

However, it is important to get the right choline source in order to make this happen in an effective manner. Other sources of choline, such as lecithin and choline bitartrate, are general choline supplements, but not all that useful for you. It is far better to have the highest quality choline products so your body isn’t being overworked and you get what you pay for.

Buy High Quality Choline

There are many different types of choline, as we mentioned before, and the Optimal Choline Complex is comprised of two of the major ones. CDP choline produces the most raw choline by weight and also has uridine benefits, which supports brain health and longevity. People who are interested in neuroprotection in addition to the anti-aging aspect can utilize choline for this purpose.

Alpha GPC is also filled with unique benefits. Some people take alpha GPC in order to increase their power output, which is a rare side effect of any supplement regarding choline. However, it makes sense given that people can see increases in their human growth hormone (hGH) while using this compound.

Together, the two choline sources combine to offer even stronger cognitive effects. This is one of the reasons why the Optimal Choline Complex is such a useful nootropic.

2 reviews for Optimal Choline Complex

  1. 5 out of 5

    (verified owner)

    Without a doubt, boosting acetylcholine levels is the first step when beginning a nootropics stack or regimen. This is a great product and I highly recommend seeing the benefits it can provide for yourself. This being a blend of two of the more/most bioavailable forms, this is a good choline supplement to start on.
    I would like to see more options on blend ratios, but offering both in one supplement is a highly effective format.

  2. 5 out of 5

    (verified owner)

    Pure Nootropics’ Optimal Choline Complex is a product I’ve been searching for for quite some time at various nootropic retail Websites. It’ priced well for the highly effecttlve balance of Choline types supplied nicely in a bottle of (green) capsules. Again, amazing product and works extremely well, and synergistically when taken with the racetams. Another top rate product from Pure Nootropics. This type of choli e, as opposed to Choline Bitartrate, especially is great. I’ve just ordered more, in fact, for the fourth time in a row.

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