Optimal Choline Complex

Product Description

Product Description

Pure Nootropics’ Optimal Choline Complex combines CDP Choline and Alpha GPC to achieve superior results. Both CDP Choline and Alpha GPC are essential nutrients which are precursors to acetylcholine. Acetylcholine is a neurotransmitter in the parts of the brain that impact memory and learning, attention, and alertness–making it one of the most beneficial neurotransmitter compounds for overall cognitive function and brain health.

Additionally, our Optimal Choline Complex facilitates increases in strength outputs, making it one of the best all round performance supplements you can take.

Optimal Choline Complex Properties

CDP Choline (also known as citicoline) is an essential nutrient and precursor to creating the neurotransmitter acetylcholine (1).

Alpha GPC Choline, is also a cholinergic compound found in the brain and a precursor to creating acetylcholine, functioning similarly to CDP Choline in acetylcholine synthesis.

Alpha GPC provides some additional advantages by increasing acetylcholine in the central nervous system and seems to be the more efficient choline precursor because of its bioavailability (2).

Optimal Choline Complex Dosage

Pure Nootropics’ Optimal Choline Complex capsules provide 200 mg of Citicoline and 100 mg of Alpha GPC.  Suggested use of Optimal Choline Complex capsules for adults is 1 capsule by mouth up to two times per day, with or without food, or as directed by your healthcare practitioner.

Alpha GPC Certificate of Analysis

CDP Choline Certificate of Analysis

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• Supports cognitive function in elderly and those with age related cognitive decline*
Di Trapani, G, and M Fioravanti. “Citicoline in the Treatment of Cognitive and Behavioral Disorders in Pathologic Senile Decline.” Clin Ter, vol. 137, no. 6, 30 June 1991, pp. 403–13., www.ncbi.nlm.nih.gov/pubmed/1832612.

• May improve attentional performance*
McGlade, E, et al. “The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.” J Atten Disord, vol. 23, no. 2, Jan. 2019, pp. 121–134., doi:10.1177/1087054715593633. https://www.ncbi.nlm.nih.gov/pubmed/26179181.

McGlade, E, et al. “Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women.” Food and Nutrition Sciences, no. 3, June 2012, pp. 769–773., doi:10.4236/fns.2012.36103. https://cognizin.com/uploads/pdfs/improve-attention-cognizin.pdf.

• May limit excitotoxicity from glutamate activity*
Cook, Sarah. “The Unique Benefits of CITICOLINE An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com/sites/default/files/uploads/citicoline.pdf.

• Promotes an increase in brain energy through improved mitochondrial function *
Cook, Sarah. “The Unique Benefits of CITICOLINE An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com/sites/default/files/uploads/citicoline.pdf.

• Supports cognitive function in the elderly with age related cognitive decline more significantly
than CDP Choline*
Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.

• May increase the production of the human growth hormone (HGH or somatropin) by working with
pituitary gland*
Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.

• Promotes increases in strength outputs during resistance training workouts*
Ziegenfuss, Tim, et al. “Acute Supplementation with Alpha-Glycerylphosphorylcholine Augments Growth Hormone Response to, and Peak Force Production during, Resistance Exercise.” Journal of the International Society of Sports Nutrition, vol. 5, no. Suppl 1, 17 Sept. 2008, p. 15., jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15.

• May enhance lower body muscle performance*
Bellar, David et al. “The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength” Journal of the International Society of Sports Nutrition vol. 12 42. 17 Nov. 2015, doi:10.1186/s12970-015-0103-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650143/.

• May provide a steadier level of choline in the body than with CDP Choline *
Gatti, G, et al. “A Comparative Study of Free Plasma Choline Levels Following Intramuscular Administration of L-Alpha-Glycerylphosphorylcholine and Citicoline in Normal Volunteers.” Int J Clin Pharmacol Ther Toxicol., vol. 30, no. 9, Sept. 1992, pp. 331–5., www.ncbi.nlm.nih.gov/pubmed/1428296?dopt=Abstract.

1. Cook, Sarah. “The Unique Benefits of CITICOLINE An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com/sites/default/files/uploads/citicoline.pdf.
2. Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.
3. McGlade, E, et al. “The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.” J Atten Disord, vol. 23, no. 2, Jan. 2019, pp. 121–134., doi:10.1177/1087054715593633. https://www.ncbi.nlm.nih.gov/pubmed/26179181.
McGlade, E, et al. “Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women.” Food and Nutrition Sciences, no. 3, June 2012, pp. 769–773., doi:10.4236/fns.2012.36103. https://cognizin.com/uploads/pdfs/improve-attention-cognizin.pdf.
4. Ziegenfuss, Tim, et al. “Acute Supplementation with Alpha-Glycerylphosphorylcholine Augments Growth Hormone Response to, and Peak Force Production during, Resistance Exercise.” Journal of the International Society of Sports Nutrition, vol. 5, no. Suppl 1, 17 Sept. 2008, p. 15., jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15.
5. Bellar, David et al. “The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength” Journal of the International Society of Sports Nutrition vol. 12 42. 17 Nov. 2015, doi:10.1186/s12970-015-0103-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650143/.
6. Gatti, G, et al. “A Comparative Study of Free Plasma Choline Levels Following Intramuscular Administration of L-Alpha-Glycerylphosphorylcholine and Citicoline in Normal Volunteers.” Int J Clin Pharmacol Ther Toxicol., vol. 30, no. 9, Sept. 1992, pp. 331–5., www.ncbi.nlm.nih.gov/pubmed/1428296?dopt=Abstract.
7. Secades, JJ, and JL Lorenzo. “Citicoline: Pharmacological and Clinical Review, 2006 Update.” Methods Find Exp Clin Pharmacol, vol. 28, no. Suppl B, 2006, pp. 1–56., www.ncbi.nlm.nih.gov/pubmed/17171187.
8. Grieb, Pawel. “Neuroprotective properties of citicoline: facts, doubts and unresolved issues” CNS drugs vol. 28,3 (2014): 185-93. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933742/.
9. Barbagallo Sangiorgi, G, et al. “Alpha-Glycerophosphocholine in the Mental Recovery of Cerebral Ischemic Attacks. An Italian Multicenter Clinical Trial.” Ann N Y Acad Sci., vol. 717, 30 June 1994, pp. 253–69., www.ncbi.nlm.nih.gov/pubmed/8030842?dopt=Abstract.
10. “Alpha-GPC.” Food, Herbs & Supplements, Professional, naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1087#safety.
11. “Choline Fact Sheet for Health Professionals.” National Institutes of Health Office of Dietary Supplements, ods.od.nih.gov/factsheets/Choline-HealthProfessional/#h2.
12. Brownawell, AM, et al. “Safety Assessment of AGPC as a Food Ingredient.” Food Chem Toxicol., vol. 49, no. 6, June 2011, pp. 1303–15., doi: 10.1016/j.fct.2011.03.012.
13. “Citicoline.” Foods Herbs & Supplements, Professional, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1090#adverseEvents.