Glutathione is the most important master antioxidant in the body (1).
- May reduce oxidative stress* (ref)
Glutathione Mode of Action
Glutathione (y-L-Glutamyl-L-cysteinyglycine) is a free radical scavenging antioxidant that is an endogenous in the body (2). It is primarily synthesized in the liver and consists of the amino acids glycine, glutamic acid, and cysteine (3).
Glutathione can be either reduced (GSH) or oxidized (GSSG). The synthesis of glutathione requires two enzymes: one to bind L-cysteine and glutamic acid together and one to add the glycine molecule to the compound to complete the glutathione molecule. It is synthesized within the cell and can be hydrolyzed into the constituent amino acids where it can be resynthesized into glutathione (2).
Together, the enzymes needed for glutathione synthesis and the enzymes which use glutathione are the “glutathione system” (2). Glutathione is an integral part of DNA synthesis and repair, amino acid transport, protein and prostaglandin synthesis, immune system function, prevention of oxidative cell damage, metabolism of toxins and carcinogens, and enzyme activation. Glutathione protects cells against harmful oxidants such as ROS (reactive oxygen species) and can increase the excretion of toxins from cells (3).
Glutathione can be sourced from meats, fruits, and vegetables but dietary intake does not raise levels of glutathione in the body. Cellular glutathione increases during exercise. Glutathione decreases with age (3).
Glutathione Capsules Dosage
Pure Nootropics’ Glutathione Capsules provides a complex of 500 mg of Glutathione (Reduced from Setria ®), 100 mg of Milk Thistle Extract (Silybum marianum standardized to 80 mg Silymarin Flavinoids), and 50 mg of Alpha-Lipoic Acid. Suggested use for adults is 1 capsule by mouth on an empty stomach daily, or as directed by your healthcare practitioner.
Glutathione Capsules Side Effects and Toxicity
Glutathione is generally well tolerated, and very few side effects have been noted. Some side effects may include flatulence, loose stools, and flushing (4).
A lethal dose was achieved in mice at a dose of 5 gm/kg (5).
For further information, please see our References Tab above.