Cordyceps is a species of medicinal mushrooms used as a traditional folk medicine in China and is now available as a medicinal mushroom extract supplement. Within the Cordyceps genus, the two most utilized and studied species are Cordyceps Militaris and Cordyceps Sinensis.
Cordyceps Militaris extract supports immune system function, may improve athletic performance, and studies in the animal model (which may not be representative of the effects in humans) suggest that it may boost testosterone, combat fatigue, and promote anti-inflammatory and anti-oxidant activity.
Cordyceps Militaris Benefits
Pure Nootropics provides Nammex medicinal mushroom extract, using only 100% organic whole fruiting bodies which are rigorously tested and guaranteed pure.
Cordyceps Militaris is emerging as a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for those studies referenced above.*
The following are examples of dynamics associated with Cordyceps Militaris through the animal model and may not be representative of the effects in the human body:
- May promote anti-inflammatory activity (ref)*
- May combat fatigue and sustain energy levels (ref)*
- May boost testosterone (ref)*
- May promote anti-oxidant activity (ref)*
Cordyceps Militaris Mushroom Mode of Action
Known as “Winter Worm Summer Grass” and as “Dong Chung Ha Cao” in Korea and “Dong Chong Xia-Cao” in China, Cordyceps undergoes a unique life cycle that begins as a fungus that colonizes caterpillars (1). It is referred to as entomopathogenic fungus (2). Supplements are commercially made with artificial propagation and fermentation (3).
Cordyceps Militaris Mushroom contains many amino acids and unsaturated fatty acids, which are found in much higher amounts in the fruiting body rather than the entirety of the mycelia body. Lysine, glutamic acid, threonine, and proline are the most abundant amino acids found in the fruiting body (1).
Cordyceps Sinensis and Cordyceps Militaris both contain Cordyceps polysaccharides, and two bioactive constituents: cordycepin and cordycepic acid. Due to their similar composition, they both share pharmacological properties (4). Cordyceps has only recently been studied and isolated within the last century in the scientific community; the number of human studies and trials are limited, but it has been well studied in animals.
In a human study of healthy adult males, Cordyceps Militaris extract capsules enhanced cell-mediated immunity (5).
In a human study, which included Cordyceps Militaris extract in a mushroom blend, an improved tolerance to high-intensity exercise was discovered. Through increasing oxygen delivery, which enhances blood flow and oxygen within the body, it may raise the anaerobic performance level and maintain energy (6).
The studies in animal models may not be representative of Cordyceps Militaris’ effects in the human body but have shown promise in the area of possibly boosting testosterone (7), possibly promoting anti-oxidant activity (8), possibly promoting anti-inflammatory activity (9), and possibly combating fatigue (10). Further research is needed in these areas.
Cordyceps Militaris Mushroom Extract Capsules & Powder Dosage
Pure Nootropics’ Cordyceps Militaris Mushroom Extract Capsules provide 500 mg per 1 capsule. Suggested use for adults is 2 capsules by mouth once daily, or as directed by your healthcare practitioner.
Pure Nootropics’ Cordyceps Militaris Mushroom Extract Powder provides 1000 mg per (2) level 1 cc scoops (provided with purchase). Suggested use for adults is 1000 mg by mouth once daily, or as directed by your healthcare practitioner. (Due to variations in powder density, scoop measurements may fluctuate. We suggest purchasing a scale for measuring accurately. A scale allows users to better track progress and response to each dose. Scales are available for purchase through Pure Nootropics).
Cordyceps Militaris Mushroom Extract Capsules & Powder Side Effects and Toxicity
Cordyceps Militaris is generally considered a non-toxic medicinal mushroom (11).
It is generally well tolerated when taken orally and appropriately and mild side effects may include diarrhea, constipation, and abdominal discomfort. Taking with food helps reduce the chance of gastrointestinal side effects (3).
A lethal dose of a specific form of Cordyceps (CordyMax Cs-4) was not achieved in animal research at a dose of 80 grams/kg. Unprocessed cordyceps achieved a lethal dose in mice at a dose of 30-50 grams/kg intraperitoneally (3).
If you are taking anticoagulants/antiplatelet medications such as aspirin, Plavix (clopidogrel), Fragmin (dalteparin), heparin, Lovenox (enoxaparin), Coumadin (warfarin), Eliquis (apixaban), and others, please consult your healthcare practitioner before beginning supplementation with Cordyceps Militaris as animal research suggests that it may inhibit platelet aggregation and function. Although not reported in humans, it is best to be moderately cautious with this combination. Herbs and supplements that may also interact in this way with anticoagulants/antiplatelet medications are clove, garlic, danshen, angelica, ginger, ginkgo, Panax ginseng and others. Although not reported in humans, it is best to be moderately cautious with this combination (3).
If you are taking immunosuppressant medications, such as Prednisolone, Cyclophosphamide, Imuran (azathioprine), Simulect (basiliximab), Neoral and Sandimmune (cyclosporine), Zenapax (daclizumab), tacrolimus, prednisone, corticosteroids, and others, please consult your healthcare practitioner before beginning supplementation because Cordyceps Militaris may stimulate the immune system and interfere with immunosuppressive therapy (3).
If you are taking anti-viral or anti-diabetic medications, please consult your healthcare practitioner before beginning supplementation of Cordyceps, as it may lower blood sugar too much or counteract the anti-viral medications (11).
Animal research has suggested that Cordyceps Militaris can increase testosterone levels but until it is further investigated, be watchful of this potential and please consult with your healthcare practitioner before beginning supplementation with Cordyceps if any hormonal concerns develop (3).
For further information, please see our References Tab above.