Nicotinamide adenine dinucleotide (NAD+)


Spend long enough in a place like Silicon Valley and conversations will frequently turn to anti-aging and longevity. Within wealthier circles of the biohacking elite, concentration, memory enhancement, and even creativity often take a backseat to longevity. It makes sense. Humans almost universally fear death. This consistent self-awareness of our own mortality combined with a God-like ego lends itself to seeking tools that increase our lifespan. One such tool among biohacking communities is NAD+ precursors like nicotinamide riboside, and nicotinamide mononucleotide, which studies show may be common and potent precursors for the NAD+ cofactor. If more NAD+ is better (for reducing aging), then any way to increase NAD+ is worth looking in to. This is why when scientists discovered nicotinamide riboside pterostilbene combinations could increase NAD+ by 40 - 90% many people paid attention… and not just the Silicon Valley types. 

A Brief Primer on NAD+

NAD+ stands for nicotinamide adenine dinucleotide, which is a coenzyme in all living cells. To simplify, NAD+ helps our cells turn food into energy that our brain and body can utilize. There is a direct correlation between having low NAD+ levels and having increased aging, death of cells, poor brain function, and a host of other effects. To maintain high levels of NAD+ with lifestyle alone, ensure healthy circadian rhythms (regular sleep schedule), reduce alcohol consumption, reduce sugar / carb consumption, and stamp out chronic inflammation. Essentially, live a health-conscious lifestyle. But even when we do this rigorously, the aging process harms our ability to produce and maintain high levels of NAD+. This is where supplementation becomes important.

Nicotinamide Riboside + Pterostilbene for Anti-Aging

The evidence is pretty clear that nicotinamide riboside supplements alone can increase NAD levels by 2.7 times the baseline, which works well either way… ...but nicotinamide riboside and pterostilbene combined work even better According to a November 2017 study from Aging and Mechanisms of Disease, dosing both nicotinamide riboside AND pterostilbene combined had a safe and sustainable positive effect on NAD+ levels. The study was well-done including randomized, double-blind, and placebo controlled elements (the gold standard) and focused on 120 healthy adults between the ages of 60 - 80. One could argue that a study focused on elderly populations (60 - 80) is less valuable, but the fact that these participants were considered healthy is refreshing and unusual. It is typically challenging to parse whether a nootropic or therapy will provide a benefit to a healthy adult if scientific literature focuses on people who are sick. To have a study that looks at healthy adults and looks at a nootropic stack (combination of ingredients) is rare and fortuitous. The reason scientists went this route is evident in their publication. Nicotinamide riboside has been studied in animal models successfully as with humans, but “...the question remained whether increases in NAD+ could be sustained over longer time courses…” Pterostilbene (a naturally occurring analog of resveratrol) was chosen because it had high bioavailability and helped to significantly increase NAD+ levels over the long term. The study focused on a single dose of 250 mg nicotinamide riboside, which boosted plasma NAD+ levels by 40%, and a double dose of 500 mg nicotinamide riboside boosted levels by 90%. These are pretty substantial increases that can have positive long term effects.

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