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Centrophenoxine Capsules

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PRODUCT INFORMATION
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PRODUCT INFORMATION

Centrophenoxine is a cholinergic compound which is a derivative of Dimethylaminoethanol (DMAE) and pCA (para-chlorophenoxyacetic acid) (1). As a cholinergic, it increases levels of acetylcholine in the brain.

  • May increase alertness and support memory (ref)*
  • May increase concentration and focus (ref)*

 

Centrophenoxine is a subject of interest in the medical community but thus far, the amount of clinical trials in humans is not plentiful. Some of these human studies are referenced above.

The following references are examples of dynamics associated with Centrophenoxine through the animal model and may not be representative of the effects in the human body:

  • Promotes antioxidant activity (ref)(ref)*
  • Supports information recall in elderly animal subjects (ref)*
  • May decrease lipofuscin (pigments related to aging) (ref)*
  • Supports RNA synthesis (ref)*

Centrophenoxine Mode of Action

Centrophenoxine is an ester (or derivative) of DMAE (Dimethylaminoethanol) that has been modified with the addition of pCA (para-chlorophenoxyacetic acid) (1). In animal research, it has demonstrated that it increases the amount of choline in the brain, by working through the presynaptic adrenoceptors of cholinergic terminals (2).

A unique function of Centrophenoxine is the ability to reduce the age-related pigment lipofuscin (3). Lipofuscins are peroxidized unsaturated fatty acids that are yellow-brown in color and are deposited in aged tissues. The lipofuscins are a combination of transition metals and oxidized lipids which cause a peroxidation reaction that produces radicals. They are mostly found deposited in neurons and cardiac cells and are believed to clog the cellular lysosome, which is responsible for cleaning waste within the cells. The lysosome then cannot digest the materials and the lipofuscin substance remains in the cell and becomes a residual body trapped in the cells (4).

The reduction of lipofuscins is attributed to Centrophenoxine’s antioxidant activity. By raising the levels of antioxidant enzymes, increased antioxidants then scavenge the peroxidized lipofuscins. Increases in SOD (superoxide dismutase) and GSH-Per (glutathione peroxidase) were noted in animal brains after ingestion of centrophenoxine (3).

The age-related decline in mRNA synthesis is also improved through Centrophenoxine in animal research. Again, it is believed to be part of the anti-oxidant promotion that increases the synthesis of mRNA which decreases with age (5).

Centrophenoxine Dosage

Pure Nootropics’ Centrophenoxine provides 250 mg per 1 capsule. Suggested use for adults is 2-4 capsules by mouth daily, or as directed by your healthcare practitioner.

Centrophenoxine Side Effects and Toxicity

Side effects are usually mild and may include headache, nausea, dizziness, gastrointestinal symptoms, and mild stimulant effects (6)(7).

DO NOT USE if pregnant. Like DMAE, Centrophenoxine can produce birth defects (8).

Some adverse events during supplementation with DMAE have raised concerns and the possibility that the events were related to DMAE could not be excluded. Please consult your healthcare practitioner before beginning supplementation, or if you are taking any medications (9).

Centrophenoxine may interact with blood pressure and it is recommended that those with severely high blood pressure avoid this supplement (9).

For further information, please see our References Tab above.

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Reference

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• May increase alertness and support memory (ref)*
Marcer, D., and Sandra M. Hopkins. “THE DIFFERENTIAL EFFECT S O F MECLOFENAMATE E O N MEMORY LOSS I N THE ELDERLY.” Age and Ageing, vol. 6, no. 123, 1977, citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1027.4608&rep=rep1&type=pdf.
• May increase concentration and focus (ref)*
Vojtechovsky, M., Soukupova, B., Safratova, V., & Votava, Z. (1970). The influence of centrophenoxine (lucidril) on learning and memory… International Journal of Psychobiology, 1(1), 49-56. https://psycnet.apa.org/record/1972-11088-001.
The following references are examples of dynamics associated with Centrophenoxine through the animal model and may not be representative of the effects in the human body:
• Promotes antioxidant activity (ref)(ref)*
Roy, D, et al. “Effect of Centrophenoxine on the Antioxidative Enzymes in Various Regions of the Aging Rat Brain.” Exp Gerontol., vol. 18, no. 3, 1983, pp. 185–97., www.ncbi.nlm.nih.gov/pubmed/6416880.
Bhalla, P, and B Nehru. “Modulatory Effects of Centrophenoxine on Different Regions of Ageing Rat Brain.” Exp Gerontol., vol. 40, no. 10, Oct. 2005, pp. 801–6., www.ncbi.nlm.nih.gov/pubmed/16137852.
• Supports information recall in elderly animal subjects (ref)*
Nandy, K. “Centrophenoxine: Effects on Aging Mammalian Brain.” J Am Geriatr Soc., vol. 26, no. 2, Feb. 1978, pp. 74–81., Centrophenoxine: effects on aging mammalian brain.
• May decrease lipofuscin (pigments related to aging) (ref)*
Roy, D, et al. “Effect of Centrophenoxine on the Antioxidative Enzymes in Various Regions of the Aging Rat Brain.” Exp Gerontol., vol. 18, no. 3, 1983, pp. 185–97., www.ncbi.nlm.nih.gov/pubmed/6416880.
• Supports RNA synthesis (ref)*
Zs-Nagy, I, and I Semsei. “Centrophenoxine Increases the Rates of Total and MRNA Synthesis in the Brain Cortex of Old Rats: an Explanation of Its Action in Terms of the Membrane Hypothesis of Aging.” Exp Gerontol., vol. 19, no. 3, 1984, pp. 171–8., www.ncbi.nlm.nih.gov/pubmed/6207041.

1. National Center for Biotechnology Information. PubChem Database. Centrophenoxine, CID=23615812, https://pubchem.ncbi.nlm.nih.gov/compound/23615812 (accessed on Mar. 22, 2019)
2. Georgiev, VP, et al. “Participation of Adrenergic Mechanisms in Brain Acetylcholine Release Produced by Centrophenoxine.” Acta Phsyiol Pharmacol Bulg., vol. 5, no. 4, 1979, pp. 21–6., www.ncbi.nlm.nih.gov/pubmed/120676.
3. Roy, D, et al. “Effect of Centrophenoxine on the Antioxidative Enzymes in Various Regions of the Aging Rat Brain.” Exp Gerontol., vol. 18, no. 3, 1983, pp. 185–97., www.ncbi.nlm.nih.gov/pubmed/6416880.
4. Cho, Sohee, and Eun Seong Hwang. Recent Advances in Cytometry, Part B, vol. 103, 2011, pp. 149–188., www.sciencedirect.com/science/article/pii/B9780123854933000073.
5. Zs-Nagy, I, and I Semsei. “Centrophenoxine Increases the Rates of Total and MRNA Synthesis in the Brain Cortex of Old Rats: an Explanation of Its Action in Terms of the Membrane Hypothesis of Aging.” Exp Gerontol., vol. 19, no. 3, 1984, pp. 171–8., www.ncbi.nlm.nih.gov/pubmed/6207041.
6. Pek G, Fulop T, Zs-Nagy I (1989) Gerontopsychological studies using NAI (‘Nurnberger Alters-Inventar’) on patients with organic psychosyndrome (DSM III, Category 1) treated with centrophenoxine in a double blind, comparative, randomized clinical trial. Arch Gerontol Geriatr 9, 17-30
7. Popa R, Schneider F, Mihalas G et al. (1994) Antagonic-stress superiority versus meclofenoxate in gerontopsychiatry type dementia)… Arch Gerontol Geriatr 19 Suppl 1, 197-206.
8. “Centrophenoxine” Examine.com, published on 2 July 2013, last updated on 14 June 2018, https://examine.com/supplements/centrophenoxine/#ref4.
9. “Centrophenoxine.” www.alzdiscovery.org/cognitive-vitality/ratings/centrophenoxine.

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Centrophenoxine Capsules

Centrophenoxine Capsules

$16.99
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