Vinpocetine is a well-known nootropic derived from the periwinkle plant. It is most commonly used as a neuroprotective as it is shown lower inflammation and reduce oxidative stress. This can assist in slowing age-related cognitive decline and assist in longevity.
Additionally, studies show Vinpocetine may improve working memory, reaction speed and overall cognitive performance. There is some indication that Vinpocetine may assist in increasing mood and overall subjective well-being, especially in the elderly and those already experiencing age-related cognitive decline.
Vinpocetine is generally taken in doses of 20 mg up to three times per day with meals for a total of 60 mg.
Vinpocetine Mode of Action
There are several ways in which Vinpocetine actually works in your body. One way it may work is as a phosphodiesterase (PDE) type-1 inhibitor, this in turn promotes cerebral blood flow and may also have cardiovascular benefit.
Vinpocetine has also been shown to slow potassium channel flow. Potassium channel blockers are associated with memory enhancement, which may explain some of the cognitive benefit seen from exposure to Vinpocetine.
Vinpocetine Side Effects & Toxicity
There are no significant side effects seen with oral doses of Vinpocetine. Minor, uncommon side effects sometimes seen include, stomach pain, nausea, sleep disturbances and headache.
Research shows LD50 for Vinpocetine is 503 mg per kilogram of body weight.