Uridine is known for supporting mood by increasing dopamine levels, and has even shown effective in treating some cases of depression. It also contributes to an increase levels of RNA, which can positively increase both short and long term memory as well as overall cognition. Uridine may be more effective for brain health and mood when combinied with a choline source and DHA.
Recommended dosage for Uridine is generally one 250mg capsule two times daily.
Mode of Action
Uridine is a precursor to CDP choline, meaning once ingested, your body metabolizes it into CDP choline, which turn increases production of phosphatidylcholine. Phosphatidylcholine is shown to play role in many functions both cognitive and physical including maintaining cell structure, fat metabolism, memory, nerve signaling, and liver health. It is also a precursor to acetylcholine.
Research shows Uridine supplementation is safe and well-tolerated when following suggested dosages. Toxicity with side effects occurs at dosages exceeding 10g.
Uridine works to increase synthesis of CDP choline leading to increased cognitive function, learning ability and overall mood.
- Improved memory function and increased synapse formation (reference)
- Increased dopamine release (ref)
- Potent anti-inflammatory and anti-fibrotic properties (ref)
- Improved mental capacity via increased number of synapses in the brain (ref)
- Enhanced the synthesis of CDP-choline, leading to increased phosphatidylcholine production (ref)
According to research, Uridine supplementation may enhance cognitive performance and benefit overall brain health. Uridine works to increase learning ability and memory by supplementing the production of acetylcholine by way of increasing CDP choline in the body.
Research also indicates that Uridine may increase dopamine release, leading to an overall increase in mood and well-being.
Uridine Studies – What’s the Research?
Uridine has been studied for a variety of purposes, both physical and cognitive. Some of those studies indicate increases in overall cognitive function, and mood, as well as a decrease in pain and inflammation. Some reserach shows this supplement may work to protect the heart and restore liver growth.
Research also indicates Uridine may be more effective when combined with omega-3 fatty acid docosahexaenoic acid (DHA) and a choline source.
Uridine Side Effects
Very minor side effects are reported with Uridine, such as headache and stomach ache, and hypersensitivity, these conditions, however are temporary uncommon and temporary.
Uridine supplementation can cause a depletion of B vitamin levels in the body, therefore it may be helpful to add a b-vitamin complex or particularly B-12.