Sulbutiamine is a derivative of Thiamine (Vitamin B1) that was first synthesized in Japan in the 1950s (1)(2).
Sulbutiamine is a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for some studies referenced above.*
The following are examples of dynamics associated with Sulbutiamine through the animal model and may not be representative of the effects in the human body:
- Supports memory (in mice) (ref)*
- May improve recognition (in rats) (ref)*
- May promote anti-oxidant activity (in vitro) (ref)*
Sulbutiamine Mode of Action
A deficiency in Vitamin B1 can cause cognitive deficits in memory and general cognition (2). The Japanese started researching the effect of diet and Vitamin B1 in the late nineteenth century due to a high mortality rate associated with sailors. They found that the highest incidence of Vitamin B1 deficiency was in the crew members who ate a diet of mostly white rice, and by improving the diet with a varied intake of meat and fish, barley, rice and beans, the mortality rate decreased. Vitamin B1 deficiency is commonly linked to a diet consisting of mostly processed white rice (3).
Sulbutiamine was synthesized to be fat-soluble and has a greater bioavailability than Vitamin B1 itself (1). Although not fully understood at this time, the benefits Sulbutiamine has for combating symptoms of fatigue is believed to be in its ability to upregulate the system involved in the sleep-wake state and fight vs. flight response. Animal research suggests that it may also work with the cholinergic, glutamatergic, and dopaminergic systems in the brain, which is believed to account for its cognitive benefits such as improving memory (4).
Sulbutiamine Capsules Dosage
Pure Nootropics’ Sulbutiamine Capsules provide 200 mg per 1 capsule. Suggested use for adults is up to 2 capsules by mouth daily, or as directed by your healthcare practitioner.
Sulbutiamine Side Effects & Toxicity
Side effects may include nausea, diarrhea, bladder infections, abdominal pain, back pain, gastroenteritis, constipation, headache, vertigo, sore throat, bronchitis, arthritic pain, and sinusitis (4, 2).
A lethal dose was achieved in rats at a dose of 5 gram/kg and in mice at 5 gm/kg (5).
For further information, please see our References Tab above.