Phosphatidylserine is a nutrient for cognitive function which is formulated into a shelf-stable soft gel capsule by Soft Gel Technologies. Smart PS™ provides the phospholipid Phosphatidylserine in a durable and convenient fluid dispersion material that prevents degradation.
Smart PS™ Benefits
- Supports cognitive function for the elderly with age-related cognitive decline (ref)*
- Supports healthy memory during age-related cognitive decline (ref)*
- Mood Support (ref)*
- May improve athletic performance (ref)*
Smart PS™ Mode of Action
Phosphatidylserine (PS) is a naturally occurring phospholipid present in membranes of cells. It is a cofactor for enzymes that work within signaling pathways, such as protein kinase C (PKC) (1). In all species, Phosphatidylserine is found in a structure of the cell membrane known as the lipid bilayer. PS increases cell fluidity and positively upregulates enzymes including ATPase and downregulates acetylcholinesterase (the enzyme that breaks down acetylcholine). Phosphatidylserine is found in the human brain, kidneys, lungs, testes, liver, heart, skeletal muscle and blood plasma. Over half of the PS found in the body is stored in neural tissue (2).
PS is necessary for healthy nerve cell membranes and myelin neural sheaths. Supplementing with PS is absorbed well in humans and crosses the blood-brain barrier where it may improve the natural deterioration of nerve cells associated with aging (3). Inadequate levels of PS inhibit brain cells from transmitting nerve signals properly (4).
PS specifically supports the memory including creating new memories, consolidating long-term memories, forming short-term memories, retrieving memories, and the ability to learn and recall information. PS also supports rapid reactions, reflexes, communication skills and language skills, and the ability to focus and concentrate (3).
The average dietary intake of PS is approximately 130 mg/day (2). PS for supplementation can be derived from bovine brain cortex (BC-PS) or soybeans (soy-PS) or synthetically manufactured (5). Bovine brain cortex is not a safe source of PS because of the risk of prion diseases like bovine spongiform encephalopathy. Soy lecithin is about 3% PS itself. Krill oil contains mostly phosphatidylcholine, rather than phosphatidylserine, and has not been a confirmed source of PS at this time (2).
Smart PS™ is a softgel enhanced with stability, as PS has a highly unstable nature. It is derived from soy lecithin and has demonstrated shelf stability of two years due to its exclusive fluid dispersion material (4).
Smart PS™ Dosage
Pure Nootropics’ Smart PS™ (Phosphatidylserine) provides 100 mg of Phosphatidylserine, 25 mg of Phosphatidylcholine, and 2.5 mg of Phosphatidylethanolamine. Suggested use for adults is 1-3 capsules by mouth daily, or as directed by your healthcare practitioner.
Smart PS™ Side Effects and Toxicity
The source of PS can be a safety concern because many studies and clinical research used bovine-cortex derived PS. The fears of contamination with diseased animals has prompted the synthesis of PS from soy or cabbage sources. Plant-derived PS has been safely used in clinical studies for up to 6 months (6).
PS is generally well-tolerated. Some side effects may include gastrointestinal upset, nausea, headache, flatulence, and insomnia. Side effects are associated with higher doses (6).
If you are taking any medications, please consult your healthcare practitioner before beginning supplementation with PS.
If you are taking AChE (acetylcholinesterase) inhibitors, such as Cognex (tacrine), Aricept (donepezil), Reminyl/Razadyne (galantamine), Exelon (reviastigmine), a moderate interaction may occur.
If you are taking anticholinergic medications, such as Cognetin (benztropine), atropine, Akineton (biperiden), Artane (trihexyphenidyl), Kemadrin (procyclidine), and others, a moderate interaction may occur.
If you are taking cholinergic medications, such as Urecholine (bethanechol), Prostigmin (neostigmine), Phospholine Iodide), Enlon/Reversol/Tensilon (edrophonium), Antilirium (physostigmine), Regonol/Mestinon (pyridostigmine), Anecetine/Quelicin (succinylcholine), and others, a moderate interaction may occur.
A lethal dose in animal research was not achieved at a dose of 70 grams daily (6).
For further information, please see our References Tab above.