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Piracetam is a nootropic compound in the racetams group.
- Piracetam (2-oxo-1-pyrrolidine-acetamide) is an organonitrogen and organooxygen compound. It is a derivative of GABA (gamma-Aminobutyric acid) and may modulate cholinergic, noradrenergic, serotonergic, and glutamatergic neurotransmitter pathways (ref)*
- The first racetam to be synthesized in 1964 and paved the way for the other racetams, such as Aniracetam, Oxiracetam, etc. (ref)*
- Assured Purity: Rigorously tested for quality & purity by third-party Certificate of Analysis*
Piracetam Chemical Properties
Piracetam is an AMPAkine which means it modulates the AMPA receptors in the hippocampus (the part of the brain associated with learning and memory). AMPA receptors interact with the glutamate neurotransmitters in the brain and lengthen the amount of time the synaptic channel is open between communicating neurons. The ability of the glutamate neurotransmitters to transmit and communicate between the synapses of neurons is then enhanced. This long-term potentiation of synaptic communication is a helpful mechanism for enhanced learning and memory (3)*.
Piracetam’s molecular formula is C6H10N2O2 and it has a molecular mass of 142.158 g/mol (1).
It is also known as UCB 6215 and the CAS Number is 7491-74-9 (1).
The oral bioavailability is near 100% for capsules, tablets, and solution. Peak plasma levels are achieved 1.5 hours after administration. Piracetam has a plasma half-life of 5 hours (2).
Pure Nootropics’ offers Piracetam in 800 mg capsules in a 60 count bottle. Bulk powder is also available to purchase in 400-gram quantities.
In preclinical safety data, Piracetam in single doses for mice reached LD 50 levels at 26 g/kg. In rats, LD 50 levels were not reached. In dogs, the lethal dose was not observed at the highest tested dose of 10g/kg. Some mild clinical signs were noted at this maximum tested dose in dogs.
Consecutive oral administration up to 1 year in dogs (at a dose of 10g/kg) and for 6 months in rats (at a dose of 2g/kg) resulted in no organ toxicity/no signs of irreversible toxicity were found (2).
For further information, please see our References Tab above.