N-Acetyl-L-Tyrosine is an acetylated form of L-Tyrosine, the amino acid which synthesizes essential neurotransmitters (1)(2).
- Increased solubility and better bioavailability than L-Tyrosine alone (ref)*
- May enhance cognition (ref)*
- May improve cognitive performance and flexibility (ref)*
- Promotes a healthy response to acute stress (ref)*
N-Acetyl-L-Tyrosine Mode of Action
Due to the poor solubility of L-Tyrosine, N-acetyl-L-tyrosine is an L-tyrosine molecule to which an acetyl molecule has been added to enhance the solubility and bioavailability of L-tyrosine (1).
L-Tyrosine is an amino acid involved in producing neurotransmitters such as dopamine and adrenaline. Being a catecholamine precursor, L-Tyrosine can be metabolized in three ways: it can be incorporated into peptides and proteins in the tissues, deaminated to form p-hydroxy phenylpyruvic acid, or hydrolyzed into L-dopa. L-Tyrosine is the rate-limiting step in the synthesis of other cathecholamines like norepinephrine and epinephrine (2).
L-Tyrosine can help stress response mechanisms during acute and uncontrollable stress. Unlike adaptogens which help alleviate symptoms of chronic stress, L-Tyrosine’s benefits regarding stress can be seen during acute and sudden stress. L-Tyrosine directly increases norepinephrine in the hippocampus and prevents stress-induced reactions in animal research (2).
L-Tyrosine may support a positive mood under stressful situations which deplete norepinephrine and dopamine from the brain (3).
L-Tyrosine can be food in chicken, turkey, milk, fish, yogurt, cheese, almonds, peanuts, soy products, pumpkin seeds, sesame seeds, avocados, and bananas (4).
Pure Nootropics’ N-Acetyl-L-Tyrosine (NALT) capsules provide 350 mg per 1 capsule. Suggested use for adults is 1 capsule by mouth daily, or as directed by your healthcare practitioner.
N-Acetyl-L-Tyrosine Side Effects and Toxicity
L-Tyrosine may affect heart rate, blood pressure, and mood, and side effects may include gastrointestinal upset, agitation, and drowsiness (2).
If you are taking any medications, please consult your healthcare practitioner before beginning supplementation with L-Tyrosine.
For further information, please see our References Tab above.