Inositol Capsules

Product Description

Inositol is a pseudovitamin found in cell membranes.  It is necessary for cellular signaling and the growth of human cells (1, 2).

Inositol Benefits

• Supports mood (ref)*
• Promotes healthy triglyceride levels (ref)*
• Maintains osmotic balance in cells, notably in the central nervous system (ref)*

Inositol Mode of Action

Inositol once belonged to the Vitamin B-complex but it is now considered a pseudovitamin because it is synthesized in the human body.  It is a sugar alcohol that is also present in dietary sources such as corn, cereal, citrus fruits, legumes, and meats (2).

A typical dietary intake provides 1 g/day of Inositiol. It is present in the highest concentration in the central nervous system tissues (CNS) and can be synthesized directly by the CNS. The kidneys can synthesize up to 4 g/day.  Therapeutic doses of 6 g/day can increase cerebrospinal fluid concentrations of insotiol by 70% (3).

Inositol includes 9 different steroisomers:  Myo-inositol, Epi-inositol, Allo-inositol, Cis-inositol, Muco-inositol, Neo-inositol, Scyllo-inositol, L-Chiro-inositol, and D-Chiro-inositol. The most common form in the body is myo-inositol which is over 90% of cellular inositol, and scyllo-inositiol is the next most abundant steroisomer.  Most supplements are formed from myo-inositol (1).

Myo-inositol is involved in the formation of cell membranes and a precursor for the phosophatidylinositol cycle.  Cellular messengers such as diacylgycerol (which regulates some of the protein kinase C functions), inositol-1,4,5-triphosphate (which modifies calcium levels within the cells), and phosphatidylinositol-3,4,5-biphosphate (which is important for signal transduction) all require Myo-inositol as a precursor (4).

Myo-inositol’s concentration in the central nervous system (CNS) is very high and the tissues in the CNS can synthesize it as well.  Myo-inositol functions as an osmolyte which can regulate the tonicity of cell fluid volume.  Inadequate levels of myo-inositol have been tied to imbalances in brain chemistry affecting mood and genetic pathologies (3).

Inositiol Dosage

Pure Nootropics’ Inositol Capsules provide 500 mg per 1 capsule.  Suggested use for adults is 1 capsule by mouth daily, or as directed by your healthcare practitioner.

Inositol Side Effects and Toxicity

Inositol is generally well tolerated.  Side effects may include diarrhea, nausea, headache, fatigue and dizziness.  Rarely, side effects may include insomica, tics, allergy symptoms, thirst, and agitation.  Toxicity information is insufficient at this time (2).

If you are taking any medications, please consult with your healthcare practitioner before beginning supplementation with Inositol (2).

For further information, please see our References Tab above.

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• Supports mood*
Fisher, Stephen K., et al. “Inositol and Higher Inositol Phosphates in Neural Tissues: Homeostasis, Metabolism and Functional Significance.” Journal of Neurochemistry, vol. 82, no. 4, Aug. 2002, pp. 736–754., doi:https://doi.org/10.1046/j.1471-4159.2002.01041.x.
• Promotes healthy triglyceride levels*
Tabrizi, R, et al. “The Effects of Inositol Supplementation on Lipid Profiles among Patients with Metabolic Diseases: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Lipids Health Dis., vol. 17, no. 1, ser. 123, 24 May 2018. 123, doi:10.1186/s12944-018-0779-4.
• Maintains osmotic balance in cells, notably in the central nervous system*
Fisher, Stephen K., et al. “Inositol and Higher Inositol Phosphates in Neural Tissues: Homeostasis, Metabolism and Functional Significance.” Journal of Neurochemistry, vol. 82, no. 4, Aug. 2002, pp. 736–754., doi:https://doi.org/10.1046/j.1471-4159.2002.01041.x.

1. “Inositol”. Examine.com, published Jun 13, 2014. Last updated Jun 14, 3018. https://examine.com/supplements/inositol/.
2. “Inositol.” Foods, Herbs & Supplements. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=299#adverseEvents.
3. Fisher, Stephen K., et al. “Inositol and Higher Inositol Phosphates in Neural Tissues: Homeostasis, Metabolism and Functional Significance.” Journal of Neurochemistry, vol. 82, no. 4, Aug. 2002, pp. 736–754., doi:https://doi.org/10.1046/j.1471-4159.2002.01041.x.
4. Carlomagno, G., and V. Unfer. “Inositol Safety: Clinical Evidences.” European Review for Medical and Phamacological Services, vol. 15, 2011, pp. 931–936., www.europeanreview.org/wp/wp-content/uploads/1015.pdf.

Inositol Certificate of Analysis