Gotu Kola (Centella asiatica) is an herb containing bioactive triterpenoids (1). Gotu Kola is a member of the parsley family and is not related to the Kola Nut (2).
Gotu Kola Benefits
- Supports healthy cognition during age-related cognitive decline (ref)*
- Mood support (ref)*
- Promotes healthy circulation (ref)*
Gotu Kola Mode of Action
Gotu Kola is native to India, Sri Lanka, Madagascar, Africa, Australia, Indonesia, and China (2). Gotu Kola’s active constituents include the triterpenoids asiatic acid and madecassic acid. It has been used in Ayurvedic medicine as well as Traditional Chinese Medicine. Today, the aerial parts of the plant are valued for its cognitive benefits (1).
The other active constituents of Gotu Kola are the other triterpene acids asiaticoside A (madecassoside) and asiaticoside B. Flavonoids such as quercetin and kaempferol, and flavone deriviatives such as stigmasterol, sesquiterpenes, sitosterol, and isothankuniside are contained in the leaves. Essential oils and nutrients such as calcium, iron, potassium, phosphorous, beta-carotene, riboflavin, thiamine, vitamin C and niacin are also present in the plant leaves (2). Gotu Kola contains a high concentration of tannins at approximately 20-25% of its composition (1).
The triterpene asiaticoside promotes anti-inflammatory activities by inhibiting the inflammatory response induced by lipopolysaccharides (LPS) and stimulates the synthesis of collagen (3). Animal research suggests that Gotu Kola’s unique saponins may promote neural growth. Gotu Kola’s ability to promote healthy circulation and relieve symptoms of venous insufficiency is due to its saponins which inhibit the enzymes hyaluronidase and elastase. These enzymes breakdown the collagen and elastin matrix outside cells and leads to fluid leakage through the cell wall, resulting in fluid accumulation and swelling, or edema (1).
Gotu Kola Dosage
Pure Nootropics’ Organic Gotu Kola Capsules provide 400 mg per 1 capsule. Suggested use for adults is 1-2 capsules by mouth daily for best results, or as directed by your healthcare practitioner.
Gotu Kola Side Effects and Toxicity
Gotu Kola is usually well tolerated. Side effects may include gastrointestinal symptoms such as irritation and nausea. There have been cases of liver toxicity linked to Gotu Kola, but it is unclear if the toxicity was from contaminants in the product which was believed to have caused the toxicity (2).
If you are taking any medications, please consult with your healthcare practitioner before beginning supplementation with Gotu Kola.
DO NOT use if you have liver disease (2).
If you are taking any herbs and supplements, such as androstenedione, comfrey, chaparral, DHEA, niacin, germander, red yeast, pennyroyal oil, and others, please consult with your healthcare practitioner before combining those with Gotu Kola (2).
If you are taking any herbs and supplements with sedative effects, such as 5-HTP, California poppy, calamus, hops, catnip, Jamaican dogwood, St. John’s wort, kava, skullcap, yerba mansa, valerian, and others, please consult with your healthcare practitioner before combining those with Gotu Kola (2).
For further information, please see our References Tab above.