DMAE

$8.99

DMAE L-Bitartrate (Dimethylethanolamine bitartrate), a salt form of the cholinergic compound DMAE formed from DMAE and tartaric acid, is the active compound in Centrophenoxine (1)(2).May support memory and cognitive function (ref)*

Supports mood when combined with a multi-vitamin (ref)*

The following references are examples of dynamics associated with DMAE through the animal model and may not be representative of the effects in the human body:

May decrease lipofuscin (pigments related to aging) (ref)*
Supports neurotransmitter function (ref)*
Promotes antioxidant activity (ref)*

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SKU: 49916 Categories: Antioxidants, Brain Health, Cholinergics, Shop, Mental Performance & Cognitive Support, Vegetarian, Mood Tags: antioxidants, cholinergics, Mental Performance & Cognitive Support, Mood, Neuroprotective, vegetarian

Product Description

DMAE L-Bitartrate (Dimethylethanolamine bitartrate), a salt form of the cholinergic compound DMAE formed from DMAE and tartaric acid, is the active compound in Centrophenoxine (1)(2).

DMAE L-Bitartrate Benefits

May support memory and cognitive function (ref)*
Supports mood when combined with a multi-vitamin (ref)*

The following references are examples of dynamics associated with DMAE through the animal model and may not be representative of the effects in the human body:

May decrease lipofuscin (pigments related to aging) (ref)*
Supports neurotransmitter function (ref)*
Promotes antioxidant activity (ref)*

DMAE L-Bitartrate Mode of Action

DMAE is naturally occurring in sardines and anchovies and in small amounts in the brain (3). As a cholinergic, DMAE is hypothesized to be methylated in the body to form choline and then converted to acetylcholine (1).

Animal research suggests that DMAE also inhibits the metabolism of choline in peripheral tissues which, in turn, allows choline to be more available in the blood and reach the brain, where it stimulates the receptors in the cholinergic pathways (4).

Acetylcholine is a neurotransmitter in the parts of the brain that impact memory and learning, attention, and alertness–making it one of the most beneficial neurotransmitter compounds for overall cognitive function and brain health (5).

DMAE can be found in body creams and face creams due to its effects on the skin and potential effects to reduce age pigment topically (2).

DMAE L-Bitartrate Dosage

Pure Nootropics’ DMAE L-Bitartrate provides 250 mg per 1 capsule. Suggested use for adults is 1 capsule by mouth once daily.

DMAE L-Bitartrate Side Effects and Toxicity

DO NOT use if pregnant or nursing. Like Centrophenoxine, DMAE can produce birth defects (6).

When taken orally, side effects may include headache, drowsiness, constipation, insomnia, urticaria, depression, hypomania, overstimulation, increase schizophrenic symptoms, blood pressure elevations, confusion, vivid dreams, and tardive dyskinesia (7).

Please consult your healthcare practitioner if you are taking any medications before beginning supplementation with DMAE.

If you are taking AChE inhibitors (acetylcholinesterase inhibitors) such as Cognex (tacrine), Aricept (donepezil), Exelon (rivastigmine), Razadyne/Reminyl (galantamine), a minor interaction may occur (7).

If you are taking anticholinergic medications, such as Cognetin (benztropine), atropine, Kemadrin (procyclidine), Akineton (biperiden), Artane (trihexyphenidyl) and others, a minor interaction may occur (7).

If you are taking cholinergic medications, such as Urecholine (bethanechol), Prostigmin (neostigmine), Phospholine Iodide (echothiophate), Enlon/Reversol/Tensilon (edrophonium), Antilirium (physostigmine), Mestinon/Regonol (pyridostigmine), Quelicin/Anectine (succinylcholine) and others, a minor interaction may occur (7)

If you have any seizure disorder, or psychological disorders such as schizophrenia, avoid using DMAE and consult your healthcare practitioner if you are taking any medications before beginning supplementation with DMAE (7).

The lethal dose of DMAE in mice was achieved at 3100 mg/kg and 1080 mg/kg in rats (1).

For further information, please see our References Tab above.

Additional Information

Weight	0.125 lbs
Quantity	60 x 250mg

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DMAE CERTIFICATE OF ANALYSIS

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition<strong. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• May support memory and cognitive function (ref)*
Blin, O, et al. “Effects of Dimethylaminoethanol Pyroglutamate (DMAE p-Glu) against Memory Deficits Induced by Scopolamine: Evidence from Preclinical and Clinical Studies.” Pyschopharmacology (Berl), vol. 207, no. 2, Dec. 2009, pp. 201–12., doi:10.1007/s00213-009-1648-7.
• Supports mood when combined with a multi-vitamin (ref)*
Dimpfel, W, et al. “Efficacy of Dimethylaminoethanol (DMAE) Containing Vitamin-Mineral Drug Combination on EEG Patterns in the Presence of Different Emotional States.” Eur J Med Res., vol. 8, no. 5, 30 May 2003, pp. 183–91., www.ncbi.nlm.nih.gov/pubmed/12844472.
The following references are examples of dynamics associated with DMAE through the animal model and may not be representative of the effects in the human body:
• May decrease lipofuscin (pigments related to aging, commonly called age spots or liver spots) (ref)*
Malanga, Gabriela, et al. “New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger .” Drug Metabolism Letters, June 2012, pp. 54–59., www.nanotechnologystore.com/(6)-New-Insights-on-DMAE-Features-as-a-Free-Radical-Scavenger.pdf.
• Supports neurotransmitter function (ref)*
Malanga, Gabriela, et al. “New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger .” Drug Metabolism Letters, June 2012, pp. 54–59., www.nanotechnologystore.com/(6)-New-Insights-on-DMAE-Features-as-a-Free-Radical-Scavenger.pdf.
• Promotes antioxidant activity (ref)*
Nagy, I, and K Nagy. “On the Role of Cross-Linking of Cellular Proteins in Aging.” Mech Ageing Dev., vol. 14, no. 1, 1980, pp. 245–51., www.ncbi.nlm.nih.gov/pubmed/7206814.

1. Masten, Scott. “Dimethylethanolamine (DMAE) [108-01-0] and Selected Salts and Esters .” Nov. 2002, ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dimethylethanolamine_508.pdf.
2. “DMAE” Examine.com, published on 2 July 2013, last updated on 14 June 2018, https://examine.com/supplements/dmae/.
3. Malanga, Gabriela, et al. “New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger .” Drug Metabolism Letters, June 2012, pp. 54–59., www.nanotechnologystore.com/(6)-New-Insights-on-DMAE-Features-as-a-Free-Radical-Scavenger.pdf
4. Haubrich, DR, et al. “Deanol Affects Choline Metabolism in Peripheral Tissues of Mice.” J Neurochem., vol. 37, no. 2, Aug. 1981, pp. 476–82., www.ncbi.nlm.nih.gov/pubmed/7264671.
5. Cook, Sarah. “The Unique Benefits of CITICOLINE An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com/sites/default/files/uploads/citicoline.pdf.
6. “Centrophenoxine” Examine.com, published on 2 July 2013, last updated on 14 June 2018, https://examine.com/supplements/centrophenoxine/#ref4.
7. “Deanol.” Foods Herbs & Supplements, Professional, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=524#safety.