DHM (Dihydromyricetin), also known as Ampelopsin and Ampelopsin grossedentata, is a flavonoid of the Japanese Raisin Tree, Hovenia dulcis (3). DHM may reduce the effects of hangovers and may assist the body in alcohol metabolism.
DHM Dihydromyricetin Capsules Benefits
- May decrease acetaldehyde (the toxic metabolite of alcohol) in humans (ref)*
- May improve lipid metabolism (ref)*
DHM is emerging as a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for those studies referenced above.*
The following are examples of dynamics associated with DHM through the animal model:
- May lessen the effects of alcohol consumption (in rats) (ref)*
- May reduce oxidative stress on the liver after alcohol consumption (in mice) (ref)*
DHM Dihydromyricetin Capsules Mode of Action
Although used for many years traditionally as Chinese medicine, scientific research on DHM and humans is scarce. The most conclusive scientific research about DHM and alcohol has been studied in animals and has shown promise in the capability of reducing the oxidative stress alcohol puts on the body and may be able to lessen the effects of acute alcohol consumption (4, 5).
Dihydromyricetin (DHM) is believed to involve GABAa R receptors (4) and reduces oxidative stress through its high superoxide radical scavenging ability, as well as inhibiting lipid peroxidation (5).
Alcohol is metabolized after consumption into two enzymes: alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Alcohol must be broken down into these enzymes for the body to eliminate it. ADH then breaks down alcohol to acetaldehyde, which is a highly toxic substance. Then acetaldehyde is broken down into acetate, which is broken down into water and carbon dioxide, and eliminated from the body (1).
(DHM) may decrease the amount of acetaldehyde in the human body (2). Acetaldehyde is the most toxic, carcinogenic byproduct of alcohol breakdown in the body. Alcohol is metabolized mostly in the liver but also in the pancreas, brain and, gastrointestinal tract. Acetaldehyde damages tissues in these areas while it waits to be broken down into acetate (1).
The body and liver can only metabolize alcohol at a certain rate, regardless of how much alcohol a person consumes. Body mass, liver size, and genetic variations regarding how efficiently the enzymes ADH and ALDH function, impact how fast alcohol can be metabolized (1).
DHM Dihydromyricetin Capsules Dosage
Pure Nootropics’ DHM Dihydromyricetin provides 300 mg per 1 capsule. Suggested use for adults is 1 capsule by mouth in the morning after consuming alcohol, or as directed by your healthcare practitioner.
DHM Dihydromyricetin Capsules Side Effects and Toxicity
The lethal oral dose in mice was greater than 5 g/kg (6).
For further information, please see our References Tab above.