DHM (Dihydromyricetin) Capsules

$24.99

DHM (Dihydromyricetin), also known as Ampelopsin and Ampelopsin grossedentata, is a flavonoid of the Japanese Raisin Tree, Hovenia dulcis (3). DHM may reduce the effects of hangovers and may assist the body in alcohol metabolism.

May decrease acetaldehyde (the toxic metabolite of alcohol) in humans (ref)*
May improve lipid metabolism (ref)*

DHM is emerging as a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for those studies referenced above.*

The following are examples of dynamics associated with DHM through the animal model:

May lessen the effects of alcohol consumption (in rats) (ref)*
May reduce oxidative stress on the liver after alcohol consumption (in mice) (ref)*

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Product Description

DHM Dihydromyricetin Capsules Benefits

May decrease acetaldehyde (the toxic metabolite of alcohol) in humans (ref)*
May improve lipid metabolism (ref)*

The following are examples of dynamics associated with DHM through the animal model:

May lessen the effects of alcohol consumption (in rats) (ref)*
May reduce oxidative stress on the liver after alcohol consumption (in mice) (ref)*

DHM Dihydromyricetin Capsules Mode of Action

Although used for many years traditionally as Chinese medicine, scientific research on DHM and humans is scarce. The most conclusive scientific research about DHM and alcohol has been studied in animals and has shown promise in the capability of reducing the oxidative stress alcohol puts on the body and may be able to lessen the effects of acute alcohol consumption (4, 5).

Dihydromyricetin (DHM) is believed to involve GABA_a R receptors (4) and reduces oxidative stress through its high superoxide radical scavenging ability, as well as inhibiting lipid peroxidation (5).

Alcohol is metabolized after consumption into two enzymes: alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Alcohol must be broken down into these enzymes for the body to eliminate it. ADH then breaks down alcohol to acetaldehyde, which is a highly toxic substance. Then acetaldehyde is broken down into acetate, which is broken down into water and carbon dioxide, and eliminated from the body (1).

(DHM) may decrease the amount of acetaldehyde in the human body (2). Acetaldehyde is the most toxic, carcinogenic byproduct of alcohol breakdown in the body. Alcohol is metabolized mostly in the liver but also in the pancreas, brain and, gastrointestinal tract. Acetaldehyde damages tissues in these areas while it waits to be broken down into acetate (1).

The body and liver can only metabolize alcohol at a certain rate, regardless of how much alcohol a person consumes. Body mass, liver size, and genetic variations regarding how efficiently the enzymes ADH and ALDH function, impact how fast alcohol can be metabolized (1).

DHM Dihydromyricetin Capsules Dosage

Pure Nootropics’ DHM Dihydromyricetin provides 300 mg per 1 capsule. Suggested use for adults is 1 capsule by mouth in the morning after consuming alcohol, or as directed by your healthcare practitioner.

DHM Dihydromyricetin Capsules Side Effects and Toxicity

The lethal oral dose in mice was greater than 5 g/kg (6).

For further information, please see our References Tab above.

Additional Information

Weight	0.3875 lbs
Dimensions	1.95 × 1.95 × 3.95 in
Quantity:	90 x 300 mg Vegetarian Capsules

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DHM CERTIFICATE OF ANALYSIS 12/2018

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• May decrease acetaldehyde (the toxic metabolite of alcohol) in humans*
Okuma, Yutaka, et al. “Effect of Extracts from Hovenia Dulcis Thunb. on Alcohol Concentration in Rats and Men Administered Alcohol.” Nippon Eiyo Shokuryo Gakkaishi, vol. 48, no. 3, 1995, pp. 167–172., doi: https://doi.org/10.4327/jsnfs.48.167.
• May improve lipid metabolism*
Chen, Shihui, et al. “Dihydromyricetin Improves Glucose and Lipid Metabolism and Exerts Anti-Inflammatory Effects…: A Randomized Controlled Trial.” Pharmacological Research, vol. 99, Sept. 2015, pp. 74–81., doi:https://doi.org/10.1016/j.phrs.2015.05.009.
• May lessen the effects of alcohol consumption (in rats)*
Shen, Yi et al. “Dihydromyricetin as a novel anti-alcohol intoxication medication.” The Journal of neuroscience : the official journal of the Society for Neuroscience vol. 32,1 (2012): 390-401. doi:10.1523/JNEUROSCI.4639-11.2012
• May reduce oxidative stress on liver after alcohol consumption (in mice)*
Wang, Mingchun, et al. “Preliminary Characterization, Antioxidant Activity in Vitro and Hepatoprotective Effect on Acute Alcohol-Induced Liver Injury in Mice of Polysaccharides from the Peduncles of Hovenia Dulcis.” Food and Chemical Toxicology, vol. 50, no. 9, Sept. 2012, pp. 2964–2970., doi.org/10.1016/j.fct.2012.06.034.

1. “Alcohol Metabolism: An Update.” National Institute on Alcohol Abuse and Alcoholism, vol. 72, July 2007, pubs.niaaa.nih.gov/publications/aa72/aa72.htm.
2. Okuma, Yutaka, et al. “Effect of Extracts from Hovenia Dulcis Thunb. on Alcohol Concentration in Rats and Men Administered Alcohol.” Nippon Eiyo Shokuryo Gakkaishi, vol. 48, no. 3, 1995, pp. 167–172., doi: https://doi.org/10.4327/jsnfs.48.167.
3. “Hovenia dulcis”. Examine.com, Published Jul 12, 2013. Last updated Oct 10, 2018. https://examine.com/supplements/hovenia-dulcis/#ref10.
4. Shen, Yi et al. “Dihydromyricetin as a novel anti-alcohol intoxication medication.” The Journal of neuroscience : the official journal of the Society for Neuroscience vol. 32,1 (2012): 390-401. doi:10.1523/JNEUROSCI.4639-11.2012
5. Wang, Mingchun, et al. “Preliminary Characterization, Antioxidant Activity in Vitro and Hepatoprotective Effect on Acute Alcohol-Induced Liver Injury in Mice of Polysaccharides from the Peduncles of Hovenia Dulcis.” Food and Chemical Toxicology, vol. 50, no. 9, Sept. 2012, pp. 2964–2970., doi.org/10.1016/j.fct.2012.06.034.
6. “Dihydromyricetin Safety Data Sheet.” Cayman Chemicals, www.caymanchem.com/msdss/23549m.pdf.