The benefits of coluracetam have not completely been identified as it is a new cognitive enhancer without a lot of research. The asserted mode of action concludes that coluracetam interacts with a process known as high affinity choline uptake (HACU), which helps to draw choline into the a neuron for synthesis into acetylcholine.
Due to the potency of coluracetam, the dosage is relatively low. Animal research indicates that an oral dose of 300 – 3,000 mcg/kg of bodyweight is useful, which translates to around 3.2-32.7mg overall for a human of 150 lbs. Research for human consumption is scarce, but anecdotal evidence suggests 20mg as a good starting dosage for coluracetam. Sublingual can make the impact of coluracetam far more potent.
Coluracetam Mode of Action
The mode of action for coluracetam is still being researched, but initial studies indicate that this nootropic interacts with the process of high affinity choline uptake (HACU). This improves a neuron’s ability to create the neurotransmitter acetylcholine, which is involved with memory formation.
Coluracetam is a potent form of the racetam compound family and should therefore be taken with caution. No animal or human trials show evidence of toxicity, but care must be taken when using coluracetam. Anecdotal reports suggest 20 mg is a good dosage and 30-35mg is a safe upper-limit.