Alpha-Lipoic Acid Capsules

Product Description

Alpha-Lipoic Acid (1,2-dithiolane-3-pentanoic acid) is an antioxidant and involved in energy metabolism as a mitochondrial enzyme cofactor (1).

Alpha Lipoic Acid Benefits

• Supports scavenging of free-radicals (ref)*
• Promotes antioxidant activity (ref)*
• Supports healthy nerve cells (ref)*
• May support healthy triglyceride levels (ref)*
• May support a healthy blood pressure (ref)*

Alpha Lipoic Acid Mode of Action

Alpha-Lipoic Acid (ALA) is created in mitochondria, specifically in the mitochondria of the liver.  It is synthesized from its precursor octanoic acid and acts a cofactor to mitochondrial enzymes alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase.  ALA also facilitates the production of acetyl-CoA through the oxidative decarboxylation of pyruvate (1).

ALA is water and fat soluble and as thiol antioxidant, it scavenges free radicals, recycles antioxidants, and chelates metal ions (2).  ALA can reduce the oxidized antioxidant glutathione, meaning that it can help activate glutathione back to a reduced form in which it will be available to neutralize more free radicals (3). Along with glutathione, ALA can also reduce Vitamin C and Vitamin E from an oxidized state and mitigate protein damage due to oxidative stress (2).

ALA can be found in dietary sources such as meat (mostly organ tissue) and fruits and vegetables.  Spinach, organ meat kidney, liver, and heart tissue, broccoli, and tomatoes are good sources of ALA (1).  Other sources of ALA in foods are potatoes, carrots, yams, beets, and yeast (4).

Alpha Lipoic Acid Dosage

Pure Nootropics’ Alpha-Lipoic Acid capsules provide 250 mg per 1 capsule.  Suggested use for adults is 1 capsule by mouth on an empty stomach, or as directed by your healthcare practitioner.

Alpha Lipoic Acid Side Effects & Toxicity

ALA is generally well tolerated.   ALA side effects may include nausea and vomiting, abdominal discomfort, a burning sensation in the esophagus, or bitter taste.  Side effects are usually associated with higher doses (4).

Extremely high doses of ALA in thiamine-deficient animals have achieved lethality.  Please consult your healthcare practitioner if you have Vitamin B1 deficiency or have a current or previous history of excessive alcohol consumption (4).

If you are taking any medications, please consult your healthcare practitioner before beginning supplementation with ALA.

If you are taking any Anticoagulant/antiplatelet medications, alkylating medications, anti-diabetes medications, chemotherapy medications, or thyroid medications, please consult your healthcare practitioner before beginning supplementation with ALA because these types of medications may interact adversely with ALA (4).

For further information, please see our References Tab above.

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• Supports scavenging of free-radicals*
Dasgupta, Amitava, and Kimberly Klein. “Chapter 16 – Herbal and Other Dietary Supplements That Are Antioxidants.” Antioxidants in Food, Vitamins and Supplements, 2014, pp. 295–315., doi:https://doi.org/10.1016/B978-0-12-405872-9.00016-1.
• Promotes anti-oxidant activity*
Hejazi, Najmeh, et al. “The Beneficial Effects of α-Lipoic Acid in Critically Ill Patients: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.” Asian Journal of Anesthesiology, vol. 56, no. 2, 1 June 2018, pp. 45–55., doi:10.6859/aja.201806_56(2).0002.
• Supports healthy nerve cells*
Shay, Kate Petersen et al. “Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.” Biochimica et biophysica acta vol. 1790,10 (2009): 1149-60. doi:10.1016/j.bbagen.2009.07.026.
• May support healthy triglyceride levels*
Haghighatdoost, F, and M Hariri. “Does Alpha-Lipoic Acid Affect Lipid Profile? A Meta-Analysis and Systematic Review on Randomized Controlled Trials.” Eur J Pharmacol., vol. 847, 15 Mar. 2019, pp. 1–10., doi:10.1016/j.ejphar.2019.01.001.
• May support a healthy blood pressure*
Boccardi, V, et al. “Elevated Blood Pressure Reduction after α-Lipoic Acid Supplementation: a Meta-Analysis of Randomized Controlled Trials.” J Hum Hypertens., 11 Feb. 2019, doi:10.1038/s41371-019-0174-2.

1. “Alpha-Lipoic Acid.” Examine.com, published Jan 5, 2015. Last updated Jun 14, 2018. https://examine.com/supplements/alpha-lipoic-acid/.
2. Higuchi, Masashi. “Chapter 15 – Antioxidant Properties of Wheat Bran against Oxidative Stress.” Wheat and Rice in Disease Prevention and Health, 2014, pp. 181–199., doi:https://doi.org/10.1016/B978-0-12-401716-0.00015-5.
3. Dasgupta, Amitava, and Kimberly Klein. “Chapter 16 – Herbal and Other Dietary Supplements That Are Antioxidants.” Antioxidants in Food, Vitamins and Supplements, 2014, pp. 295–315., doi:https://doi.org/10.1016/B978-0-12-405872-9.00016-1.
4. “Alpha-Lipoic Acid.” Food, Herb, & Supplements Database. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=767.

Alpha Lipoic Acid Certificate of Analysis