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Alpha GPC 50% Capsules & Powder
$10.99 – $21.99
Product Description
Alpha GPC Choline 50% (capsules and powder) is a cholinergic compound found in the brain and a precursor to creating acetylcholine. Alpha GPC provides some additional advantages by increasing acetylcholine in the central nervous system and seems to be the more efficient choline precursor because of its bioavailability (1).
Alpha GPC Benefits
- Supports cognitive function in the elderly at high doses (ref)*
- May increase the production of the human growth hormone (HGH or somatropin) by working with pituitary gland (ref)*
- Promotes increases in strength outputs (ref)*
- May enhance lower body muscle performance (ref)*
Alpha GPC Mode of Action
Alpha GPC Choline, an abbreviation for Alpha-glycerylphosphorylcholine, is a cholinergic compound found in the brain and a precursor to creating acetylcholine, functioning similarly to other choline sources in acetylcholine synthesis. Alpha GPC provides some additional advantages by increasing acetylcholine in the central nervous system and seems to be the more efficient choline precursor because of its bioavailability (2).
Acetylcholine is a neurotransmitter in the parts of the brain that impact memory and learning, attention, and alertness–making it one of the most beneficial neurotransmitter compounds for overall cognitive function and brain health (3). Supplementing with an acetylcholine precursor may promote an enhancing effect on these areas and support overall brain function.
Alpha GPC is found in many several dietary sources (animal-based products, eggs, whole grains, cruciferous vegetables, nuts, and seeds) and is a nutrient that is difficult to reach an adequate level from diet alone (3).
By working directly with the pituitary gland, Alpha GPC may increase the production of the human growth hormone (2). Preliminary trials relating to Alpha GPC administered to healthy volunteers prior to resistance exercise have shown promise in possibly increasing strength output during workouts, presumably due to its influence on HGH (4).
The ability of Alpha GPC to enhance lower body muscle performance related to isometric exercise is also being studied (5). Alpha GPC is often found in fitness supplements because of its ability to increase power.
Alpha GPC 50% Capsules and Powder Dosage
Pure Nootropics uses Alpha GPC derived from soy and is generally considered a natural source.
Pure Nootropics’ Alpha GPC 50% Capsules provides 250 mg of Alpha GPC. Suggested use of Alpha GPC Capsules for adults is 1 capsule by mouth, up to two times per day, or as directed by your healthcare practitioner.
Pure Nootropics’ Alpha GPC 50% powder provides 300 mg per rounded 0.625 cc scoop (provided with purchase). Suggested use of Alpha GPC 50% powder is 1 scoop by mouth, up to two times per day, or as directed by your healthcare practitioner. (Due to variations in powder density, scoop measurements may fluctuate. We suggest purchasing a scale for measuring accurately. A scale allows users to better track progress and cognitive response to each dose. Scales are available for purchase through Pure Nootropics).
Alpha GPC 50% Capsules and Powder Side Effects and Toxicity
The safety of long-term use of Alpha GPC is not known. It is generally well-tolerated, but as with all supplements and medications, some people may experience side effects. It is considered possibly safe and side effects from Alpha GPC are mild and could include heartburn, nausea, vomiting, insomnia or excitation, and headache (6,7).
Toxicity information for Alpha GPC has been extrapolated from animal studies and demonstrates that the “No Observed Adverse Effect Level” (NOAEL) for humans was for a dose at least 150 mg/kg over a six-and-half month timespan (8).
Please consult your healthcare practitioner if you are taking any medications prior to beginning supplementation with Alpha GPC. Do not use if you are pregnant or nursing.
For further information, please see our References Tab above.
Additional Information
| Weight | N/A |
|---|---|
| Dimensions | N/A |
| Quantity | 60 x 250mg Capsules, 15g (powder only), 30g (powder only) |
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The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• Supports cognitive function in the elderly at high doses significantly more
than other cholinergics*
Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.
• May increase the production of the human growth hormone (HGH or somatropin) by working with
pituitary gland*
Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.
• Promotes increases in strength outputs during resistance training workouts*
Ziegenfuss, Tim, et al. “Acute Supplementation with Alpha-Glycerylphosphorylcholine Augments Growth Hormone Response to, and Peak Force Production during, Resistance Exercise.” Journal of the International Society of Sports Nutrition, vol. 5, no. Suppl 1, 17 Sept. 2008, p. 15., jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15.
• May enhance lower body muscle performance*
Bellar, David et al. “The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength” Journal of the International Society of Sports Nutrition vol. 12 42. 17 Nov. 2015, doi:10.1186/s12970-015-0103-x.
• May provide a steadier level of choline in the body than [other choline sources] Gatti, G, et al. “A Comparative Study of Free Plasma Choline Levels Following Intramuscular Administration of L-Alpha-Glycerylphosphorylcholine and Citicoline in Normal Volunteers.” Int J Clin Pharmacol Ther Toxicol., vol. 30, no. 9, Sept. 1992, pp. 331–5., www.ncbi.nlm.nih.gov/pubmed/1428296?dopt=Abstract.
1. Gatti, G, et al. “A Comparative Study of Free Plasma Choline Levels Following Intramuscular Administration of L-Alpha-Glycerylphosphorylcholine …” Int J Clin Pharmacol Ther Toxicol., vol. 30, no. 9, Sept. 1992, pp. 331–5., www.ncbi.nlm.nih.gov/pubmed/1428296?dopt=Abstract.
2. Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.
3. Cook, Sarah. “The Unique Benefits of … An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com.
4. Ziegenfuss, Tim, et al. “Acute Supplementation with Alpha-Glycerylphosphorylcholine Augments Growth Hormone Response to, and Peak Force Production during, Resistance Exercise.” Journal of the International Society of Sports Nutrition, vol. 5, no. Suppl 1, 17 Sept. 2008, p. 15., jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15.
5. Bellar, David et al. “The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength” Journal of the International Society of Sports Nutrition vol. 12 42. 17 Nov. 2015, doi:10.1186/s12970-015-0103-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650143/.
6. Barbagallo Sangiorgi, G, et al. “Alpha-Glycerophosphocholine…An Italian Multicenter Clinical Trial.” Ann N Y Acad Sci., vol. 717, 30 June 1994, pp. 253–69., www.ncbi.nlm.nih.gov/pubmed/8030842?dopt=Abstract.
7. “Alpha-GPC.” Food, Herbs & Supplements, Professional, naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1087#safety.
8. Brownawell, AM, et al. “Safety Assessment of AGPC as a Food Ingredient.” Food Chem Toxicol., vol. 49, no. 6, June 2011, pp. 1303–15., doi: 10.1016/j.fct.2011.03.012.
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Sid (verified owner) –
Have no complaints about this product so far. I switched over from CDP Choline to stack with my other nootropics and don’t notice too much of a difference but I generally don’t notice a significant difference in mood or my demeanor from choline. It has so far held off any headache side effects you may receive from time to time if you use other nootropics such as noopept or oxyracetam with no choline supplement to stack them with. I like this company for the variety of powders they have available. Since I use 4-5 different substances in my stack it’s nice to just mix into a drink rather than have to take that many capsules a day.
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Alpha_Australia (verified owner) –
The tub of powder makes no mention of being 50%, and like my previous order the plastic seal had not prevented moisture from entering on the trip to Australia. The powder had congealed before use.
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Admin Eric Balaster (verified owner) –
Hello,
We generally try to address these matters via our customer service e-mail, but didn’t get one. Ordinarily, we will simply replace your item when there is an issue (we suggest you contact us via e-mail if you have a problem with any of our products in the future).
Although our tubs don’t explicitly say 50% on them, that is the only version of Alpha GPC we carry; Alpha GPC 99% is hygroscopic and we don’t carry it for this exact reason (it’s also a much more expensive product, so if we did carry it, we would need to charge more for it). Although it is possible that the 50% congealed in a high humidity environment, you are the only customer that has indicated this to be an issue. Also, storage of the product may be an issue as we see your comment was made in February, 2019 and we shipped the product to you in June, 2018. You can also see the certificate of analysis that accompanies our products which indicates Alpha GPC 50% in this instance.
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Gina T –
I have been using these capsules for over a year and have found a marked improvement in overall cognition. It certainly has diminished my brain fog. I’ve been using this with the magnesium and fish oil products and feel that all three combined have made a difference in my sleep and mood as well.
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Louis D. (verified owner) –
Quality! No Compromises! I can feel the difference!
First time nootropic user here. I was concerned about getting quality materials & using this stuff correctly. After being recommended this brand from a friend, I was subsequently astonished by the results of this, alongside the results of Noopept from PureNootropics, these two are definitely amazing products. This isn’t even a paid review – it’s just that good of stuff.
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Robert P. (verified owner) –
Tried alone, then with Noopept – no positive cognative effects, slight increase in fogginess. Not a fit
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Jeffrey R. (verified owner) –
Seems to provide the desired effect in my stack.
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Robert L. (verified owner) –
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Felipe R. (verified owner) –
Works well with pitacetam. Great price!
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Michelle R. (verified owner) –
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Jerry H. (verified owner) –
I take 2 before a workout and feel AMAZING!!!
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Raymond F. (verified owner) –
This is the boost you need.
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Mariel M. (verified owner) –
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Caleb (verified owner) –
Best source for choline, the only choline supp I will take! Gets rid of those annoying nootropic headaches that can happen
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J (verified owner) –
Awesome with any racetams to keep headaches at bay.
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