Alpha GPC 50% Capsules & Powder

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Supports cognitive function in the elderly at high doses (ref)*
May increase the production of the human growth hormone (HGH or somatropin) by working with pituitary gland (ref)*
Promotes increases in strength outputs (ref)*
May enhance lower body muscle performance (ref)*

Product Description

thirdpartysafety

Alpha GPC Choline 50% (capsules and powder) is a cholinergic compound found in the brain and a precursor to creating acetylcholine. Alpha GPC provides some additional advantages by increasing acetylcholine in the central nervous system and seems to be the more efficient choline precursor because of its bioavailability (1).

Alpha GPC Benefits

Supports cognitive function in the elderly at high doses (ref)*
May increase the production of the human growth hormone (HGH or somatropin) by working with pituitary gland (ref)*
Promotes increases in strength outputs (ref)*
May enhance lower body muscle performance (ref)*

Alpha GPC Mode of Action

Alpha GPC Choline, an abbreviation for Alpha-glycerylphosphorylcholine, is a cholinergic compound found in the brain and a precursor to creating acetylcholine, functioning similarly to other choline sources in acetylcholine synthesis. Alpha GPC provides some additional advantages by increasing acetylcholine in the central nervous system and seems to be the more efficient choline precursor because of its bioavailability (2).

Acetylcholine is a neurotransmitter in the parts of the brain that impact memory and learning, attention, and alertness–making it one of the most beneficial neurotransmitter compounds for overall cognitive function and brain health (3). Supplementing with an acetylcholine precursor may promote an enhancing effect on these areas and support overall brain function.

Alpha GPC is found in many several dietary sources (animal-based products, eggs, whole grains, cruciferous vegetables, nuts, and seeds) and is a nutrient that is difficult to reach an adequate level from diet alone (3).

By working directly with the pituitary gland, Alpha GPC may increase the production of the human growth hormone (2). Preliminary trials relating to Alpha GPC administered to healthy volunteers prior to resistance exercise have shown promise in possibly increasing strength output during workouts, presumably due to its influence on HGH (4).

The ability of Alpha GPC to enhance lower body muscle performance related to isometric exercise is also being studied (5). Alpha GPC is often found in fitness supplements because of its ability to increase power.

Alpha GPC 50% Capsules and Powder Dosage

Pure Nootropics uses Alpha GPC derived from soy and is generally considered a natural source.

Pure Nootropics’ Alpha GPC 50% Capsules provides 250 mg of Alpha GPC. Suggested use of Alpha GPC Capsules for adults is 1 capsule by mouth, up to two times per day, or as directed by your healthcare practitioner.

Pure Nootropics’ Alpha GPC 50% powder provides 300 mg per rounded 0.625 cc scoop (provided with purchase). Suggested use of Alpha GPC 50% powder is 1 scoop by mouth, up to two times per day, or as directed by your healthcare practitioner. (Due to variations in powder density, scoop measurements may fluctuate. We suggest purchasing a scale for measuring accurately. A scale allows users to better track progress and cognitive response to each dose. Scales are available for purchase through Pure Nootropics).

Alpha GPC 50% Capsules and Powder Side Effects and Toxicity

The safety of long-term use of Alpha GPC is not known. It is generally well-tolerated, but as with all supplements and medications, some people may experience side effects. It is considered possibly safe and side effects from Alpha GPC are mild and could include heartburn, nausea, vomiting, insomnia or excitation, and headache (6,7).

Toxicity information for Alpha GPC has been extrapolated from animal studies and demonstrates that the “No Observed Adverse Effect Level” (NOAEL) for humans was for a dose at least 150 mg/kg over a six-and-half month timespan (8).

Please consult your healthcare practitioner if you are taking any medications prior to beginning supplementation with Alpha GPC. Do not use if you are pregnant or nursing.

For further information, please see our References Tab above.

Additional Information

Weight	N/A
Dimensions	N/A
Quantity	60 x 250mg Capsules, 15g (powder only), 30g (powder only)

Alpha GPC Certificate of Analysis 09/2018

Alpha GPC Certificate of Analysis 05/2017

The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• Supports cognitive function in the elderly at high doses significantly more
than other cholinergics*
Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.

• May increase the production of the human growth hormone (HGH or somatropin) by working with
pituitary gland*
Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.

• Promotes increases in strength outputs during resistance training workouts*
Ziegenfuss, Tim, et al. “Acute Supplementation with Alpha-Glycerylphosphorylcholine Augments Growth Hormone Response to, and Peak Force Production during, Resistance Exercise.” Journal of the International Society of Sports Nutrition, vol. 5, no. Suppl 1, 17 Sept. 2008, p. 15., jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15.

• May enhance lower body muscle performance*
Bellar, David et al. “The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength” Journal of the International Society of Sports Nutrition vol. 12 42. 17 Nov. 2015, doi:10.1186/s12970-015-0103-x.

• May provide a steadier level of choline in the body than [other choline sources] Gatti, G, et al. “A Comparative Study of Free Plasma Choline Levels Following Intramuscular Administration of L-Alpha-Glycerylphosphorylcholine and Citicoline in Normal Volunteers.” Int J Clin Pharmacol Ther Toxicol., vol. 30, no. 9, Sept. 1992, pp. 331–5., www.ncbi.nlm.nih.gov/pubmed/1428296?dopt=Abstract.

1. Gatti, G, et al. “A Comparative Study of Free Plasma Choline Levels Following Intramuscular Administration of L-Alpha-Glycerylphosphorylcholine …” Int J Clin Pharmacol Ther Toxicol., vol. 30, no. 9, Sept. 1992, pp. 331–5., www.ncbi.nlm.nih.gov/pubmed/1428296?dopt=Abstract.
2. Linder, Leah. “Alpha-GPC – An Overview.” Klaire Research and Science Healthcare Professional Article, May 2018, klaire.com/researchandscience/hcp-articles/alpha-gpc-an-overview/.
3. Cook, Sarah. “The Unique Benefits of … An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com.
4. Ziegenfuss, Tim, et al. “Acute Supplementation with Alpha-Glycerylphosphorylcholine Augments Growth Hormone Response to, and Peak Force Production during, Resistance Exercise.” Journal of the International Society of Sports Nutrition, vol. 5, no. Suppl 1, 17 Sept. 2008, p. 15., jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15.
5. Bellar, David et al. “The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength” Journal of the International Society of Sports Nutrition vol. 12 42. 17 Nov. 2015, doi:10.1186/s12970-015-0103-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650143/.
6. Barbagallo Sangiorgi, G, et al. “Alpha-Glycerophosphocholine…An Italian Multicenter Clinical Trial.” Ann N Y Acad Sci., vol. 717, 30 June 1994, pp. 253–69., www.ncbi.nlm.nih.gov/pubmed/8030842?dopt=Abstract.
7. “Alpha-GPC.” Food, Herbs & Supplements, Professional, naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1087#safety.
8. Brownawell, AM, et al. “Safety Assessment of AGPC as a Food Ingredient.” Food Chem Toxicol., vol. 49, no. 6, June 2011, pp. 1303–15., doi: 10.1016/j.fct.2011.03.012.

Alpha GPC 50% Capsules & Powder