Agmatine is a decarboxylated derivative of the amino acid L-arginine (1). L-arginine is an amino acid which may improve exercise duration (2).
Agmatine Sulfate Benefits
- May alleviate pain in pinched nerves (ref)*
Agmatine Sulfate is emerging as a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans.*
The following are examples of dynamics associated with Agmatine Sulfate through the animal model and may not be representative of the effects in the human body:
- Supports mitochondrial health (in vitro)(ref)*
- Promotes antioxidant activity (in vitro)(ref)*
- May provide mood support (ref)(ref)*
- May promote healing after an injury to nerves (in rodents)(ref)*
Agmatine Sulfate Mode of Action
Agmatine is an amine molecule that is involved in signaling in the human body. It is a bacterial byproduct and is distinguished by the enzyme which synthesizes agmatine from arginine and can be found in fermented foods such as wine, beer, sake, fish, meat products, and coffee. (1).
Agmatine is endogenously produced and is found in the spinal cord and brain and works both as an N-methyl-D-aspartate (NMDAR) antagonist and a nitric oxide synthase (NOS) inhibitor (3). Research at this time proposes that agmatine is a neurotransmitter-neuromodulator, as it is made, stored, and released in the brain. It is also found in neurons and neural axon terminals. Agmatine interacts with cell-specific receptors and interacts with actions within the central nervous system. However, its role in brain function has not yet been determined because researchers are still studying its biosynthesis and degradation (4).
Agmatine is expressed in the brain in high concentrations in the inferior section of the hippocampus and cerebral cortex. It crosses the blood-brain barrier. It is interesting to note that administering L-arginine does not increase agmatine concentrations itself (1).
Agmatine promotes antioxidant activity by preventing the oxidation of sulfhydryl groups and decreases hydrogen peroxide content (5).
Agmatine Sulfate Dosage
Pure Nootropics’ Agmatine Sulfate provides 500 mg per 1 capsule. Suggested use for adults is 1 capsule by mouth daily, or as directed by your healthcare practitioner.
Agmatine Sulfate Side Effects and Toxicity
Side effects noted in the human clinical study include transient gastrointestinal discomfort at high doses (1).
A lethal dose was achieved in mice at a dose of 300 mg/kg, 3200 mg/kg in rabbits, and 980 mg/kg in rats (1).
There is limited data on toxicity in humans, but studies have reported no known side-effects. Short term safety data is available that shows it is safe for up to 21 days. Another study tested the long-term effects of administration up to 115 days and found no adverse effects (6).
For further information, please see our References Tab above.