Adrafinil is (diphenylmethyl)sulfinyl-2-acetohydroxamic acid
- Molecular formula: C15H15NSO3
- Molecular weight: 289.35
- May improve vigilance and memory (ref)*
- Promotes wakefulness (ref)*
- Promotes concentration and attention (ref)*
- Mood support in the elderly (ref)*
Note: Banned substance under the World Anti-Doping Agency (WADA) (ref)*
Adrafinil Mode of Action
Adrafinil directly affects the central nervous system, but its exact mechanisms of actions have yet to be discovered. Animal research theorizes that Adrafinil works as an a1-adrenergic receptor agonist and affects amino acid release such as glutamate while decreasing the release of GABA (1).
Adrafinil is an eugregoric agent, meaning that it promotes wakefulness and alertness without amphetamine-like effects. The World Anti-Doping Agency (WADA) classifies it a “non-specified stimulant” (2).
When ingested, Adrafinil metabolizes into the active modafinil, which is then metabolized into inactive modafinilic acid, or the inactive modafinilic sulfone. Adrafinil can also metabolize into the inactive modafinilic acid which bypasses modafinil entirely (2).
Pure Nootropics’ Adrafinil provides 300 mg per 1 capsule.
Bulk powder options are available in 15 gram and 30 gram quantities.
Pure Nootropics’ Adrafinil powder provides 300 mg per (4) level 0.15 cc scoops (provided with purchase). *Due to variations in powder density, scoop measurements may fluctuate. We suggest purchasing a scale for measuring accurately. A scale allows users to better track progress and response to each dose. Scales are available for purchase through Pure Nootropics.
Adrafinil Side Effects and Toxicity
Many clinical trials with Adrafinil had very little or no side effects; however, side effects may include hyperactivity at large doses, agitation, aggression, nausea, irregular heartbeat, dyskinesia, drowsiness, and others. At standard doses, long term use of 3 years or more did not result in harmful side effects, tolerance, or dependence (1).
If you are taking any medications, please consult with your healthcare practitioner about any possible interactions before beginning supplementation with Adrafinil.
The lethal dose in mice and rats is approximately 3400 mg/kg (1).
For further information, please see our References Tab above.