Piracetam can improve memory and learning, but it interacts with many other compounds. There are many piracetam interactions that can improve the efficacy and safety of this nootropic drug. These include beneficial interactions with choline as well as negative reactions with other substances. This section is full of articles that will help you take piracetam safer and more effectively.

Quick Interaction Tips:

  • Piracetam and choline enhance cognitive abilities even more
  • Supplement with choline to prevent side effects of piracetam
  • Piracetam and alcohol can increase intoxication

piracetam and choline

The psychoactive ingredients we consume every day can have a different impact on our brain and body while taking piracetam. Because piracetam is a mild altering substance, it interacts with things like alcohol and other substances that are important to know.

While piracetam is actually a neuroprotective and can usually have positive effects on your brain, there are some situations where it is important to be careful.

Piracetam and Choline Interactions

The number one substance that interacts with piracetam is choline because this is the precursor for the neurotransmitter, acetylcholine, which is responsible for memory formation. Piracetam increases uptake and utilization of acetylcholine in regions of the brain like the hippocampus, which are dedicated to memory formation.

This is one of the reasons piracetam and choline provide enhanced cognition greater than each of the individual parts. However, some people that use piracetam notice they can see headaches if they don’t get enough. The piracetam and choline headaches are probably a side effect of not getting enough choline in order to make the best use of piracetam.

Most people think that the piracetam and choline in mice studies is not enough to show how it can help for humans, but the drug has been around for over 40 years. In that time, piracetam and choline have been studied on humans and animals alike to show the positive reactions.

Finding the right ratio of choline and piracetam might be a harder task. The piracetam choline ratio explained is not simple because there are multiple types of choline. While the piracetam benefits in animal studies is obvious when using choline, the researchers used a specific kind of choline. You, however, must figure out the different piracetam and choline types (such as CDP choline and alpha GPC) so that you can get the best results.

Alcohol & Other Substances

For thousands of years alcohol has been the social lubricant that people of all classes enjoyed. In fact, while fresh water was scarce, alcohol often provided the alternative that many people loved. If you are mixing alcohol with piracetam, there are a few things you should know.

For one, piracetam and alcohol quantity consumed will be much less than usual. You can get intoxicated quicker with piracetam in most cases. The piracetam and alcohol potency is higher so you don’t need as many drinks as you might otherwise need. However, people who struggle with long term addiction can see tremendous benefits with piracetam. The drug can reverse years of abuse and provide help with withdrawal symptoms. While there are few piracetam and alcohol withdrawal studies, it is positive evidence that piracetam is a multi-faceted smart drug.

Other psychoactive substances, such as MDMA, can have effects on the brain with piracetam as well. It is important to try not to mix the substances together. If you can take your piracetam dosage in the morning, there is a good chance it will largely be out of your system in time for you to enjoy other substances.

2 thoughts on “Piracetam Interactions

    • PureNootropics says:


      There has been studies of piracetam in conjunction with anti-epilepsy medication (reference) in mice. The study shows that piracetam didn’t have adverse interactions with such medication. It was also studied in a small group of patients with Myoclonus Epilepsy and showed improvement as an add-on medication (reference). Anecdotal information suggests that piracetam should not be suddenly stopped by Myclonic patients as that can cause problems. However, for anyone that does take medication to reduce seizures, it would be highly recommended to consult with your physician before taking piracetam or any other racetams for that matter.

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