Knowledge Base

Welcome to the Pure Nootropics Knowledge Base!

The purpose of this section is to help you better understand nootropic compounds in general and the specifics of some of the nootropics we carry. For someone new to nootropics, we suggest you start here:

Before getting too far we want to mention that nootropics are a very subjective experience and while a particular compound works for one individual it may not work for another, this is why we put together a tutorial for tracking mental improvements with nootropics that you can use to track the efficacy of a particular compound.

For anyone seeking general overall cognitive enhancement, optimum nutrition, diet, and lifestyle are the best starting points. This includes simple things like getting a proper amount of sleep (check out our sleep guide for tips on falling asleep and staying asleep) and getting enough micro-nutrients (see our posts on the importance of Choline, getting your omega 3’s, and why you should be supplementing Vitamin D for more information, as a large number of individuals are deficient in one of these).

For more specific information about particular nootropics, each section below covers:

  • Different decisions when buying nootropics
  • Interactions with other compounds
  • Side effects / benefits
  • Studies

There are a wide variety of nootropics as it is a broad category that encompasses many synthetic and natural compounds. The term was derived in the early 1970s and some of the most popular nootropics are part of the “racetam” family. Note that we provide more information about each item on its respective product page under the “full analysis” tab.



The first and most popular of these is called piracetam, which was discovered nearly 4 decades ago as a derivative of the neurotransmitter GABA. This smart drug is a popular option among elderly and youth alike because of the intense memory enhancement and improved learning ability for users.

Many people use piracetam as a beginner nootropic to have a product that is potent and effective, but is not overwhelming. Starting with piracetam is known to be a great beginner stack on many of the most well-established communities, such as Longecity and Reddit.

Even though piracetam is not extremely potent, it can create feelings of mood enhancement, reduced anxiety, and even improves focus and concentration in some individuals.



This is the second most common racetam and it was discovered not long after piracetam. Aniracetam is a very fast acting nootropic that improves memory formation and learning, but also increases stimulation. Because it has a high bioavailability (meaning it absorbs quickly), it is fast acting and more potent than piracetam, but it requires more doses throughout the day.

For most people who are trying to improve mental energy, get some stimulation, and improve learning, aniracetam is a great choice. It is often used in addition to piracetam as part of a nootropic stack that is focused on racetams.



Often considered one of the most potent racetams, oxiracetam has a long history of neuro protection. Many studies show that oxiracetam can not only halt, but also reverse neurological decline. Sometimes this can translate into reversing damage from trauma (whether chemical or physical) that people suffer earlier in life.

This smart drug is used to treat many memory related illnesses, such as Alzheimer’s and dementia. It is also useful for younger individuals who are seeking enhanced memory and learning. For most people, this is an advanced, but very safe nootropic addition.



Considered 60 times more potent than piracetam, this nootropic is a great boost of mental energy with the same memory enhancement benefits of the entire racetam family. Phenylpiracetam is so stimulating, the olympic organizations have banned the substance for athletes, but that doesn’t mean you cannot use it to your advantage!

As a highly potent nootropic drug, phenylpiracetam is also very bioavailable which means taking smaller doses more frequently is a good idea.


Alpha GPC

Alpha GPC

Finding a choline source for your racetams is imperative because this supplement is a precursor for the neurotransmitter acetylcholine. This brain chemical is often responsible for creating memories and it is how piracetam and other drugs are most effective in helping you to learn. Without adequate choline, it is possible to suffer from headaches and other jaw pains that are side effects of low acetylcholine.

It is best to use two types of choline called CDP choline (citicholine) and alpha GPC, which are higher in their bioavailability and will provide more raw choline for you to improve your memory and prevent side effects.



Another great nootropic drug is noopept, which is extremely potent. It is considered 1000 times more potent than piracetam, which means the doses are lower and it is important to be precise! Noopept will also help to improve memory formation and learning ability, but it does so through the glutamate receptors as opposed to the mechanisms of racetams.

This is a great drug to use if you want a potent stimulant that will also help to improve your memory. Some people even consider noopept a great way of reducing anxiety and improving general mood, but it will depend on your biochemistry how you react.



This is an all-natural amino acid found in green tea. L-theanine is associated with more alpha brain waves, which are correlated with relaxation. For most people, relaxed brain waves are different from the common high stimulation environment we all live in!

Combining L-theanine with a morning cup of coffee is considered one of the best nootropics for beginners who are interested in focus and attention. Numerous studies show the combined positive effects of caffeine and L-theanine, which are more profound than either of the two alone!


Derived from the nutrient thiamine (vitamin B1), sulbutiamine is a well-absorbed supplement that more easily crosses the blood-brain barrier. Japanese scientists in the early 20th century tried to develop synthetic options to consume more thiamine because deficiency was so common. Finally, in 1936 sulbutiamine was discovered and has been used as a drug ever since.

It wasn’t until recently when the brain enhancing effects of sulbutiamine became more apparent. It is a treatment for fatigue (both mental and physical) and there is evidence it supports brain function through neuroprotection, improves memory retention, and has a positive effect on mental energy.


Researchers during the Soviet Union were hard at work developing treatments to improve brain function and one of their results was phenibut. This derivative of GABA (a chemical in your brain) easily crosses the blood-brain barrier and helps to treat anxiety, PTSD, as well as depression and a variety of other stress-related disorders.

According to a study in 2013, it is a powerful stress-reducing drug, but needs to be cycled in order to prevent dependence.


One of the most popular smart drugs on the market is within the family called “Modafinil”. Many people avoid buying Modafinil because it is a scheduled substance in the United States, but one alternative is Adrafinil. This is a prodrug for Modafinil that improves wakefulness and concentration in order to complete certain tasks. Users of Adrafinil fin that it has slightly different cognitive effects than Modafinil even though it is supposed to be converted into that drug in the body.

In addition to being a wakefulness agent, Adrafinil has been noted as a tool for improving concentration, focus, and alertness beyond that of caffeine. Best of all, it is unscheduled in the United States so no shady online buys from a pharmacy you might not be able to trust!

Bacopa Monnieri

Ancient Ayurvedic wisdom is on heavy display with bacopa monnieri. This plant-based nootropic has been used by Indians to develop improved memory and cognitive function for over 3000 years. Some claim this Ayurvedic remedy has been around for nearly 5000. Because of the popularity in Indian culture and cognitive medicine, it has garnered much attention in the western research laboratory as well.

Unlike some of the Ayurvedic options on the market, bacopa monnieri has had spectacular scientific trials that prove efficacy with a number of different indicators. Some of the most successful nootropic blends, such as Alpha Brain, are using this as a core ingredient to improve cognitive function.


This traditional Indian remedy for anxiety has received much attention due to its popularity in Asia. Since modern research in nootropic products began, ashwagandha has consistently proven itself as one of the more popular methods of improving mental performance by reducing the anxiety and stress being caused to an individual.

There is preliminary evidence that ashwagandha can also improve certain aspects of attention and focus, but they are less well-studied as the anti-anxiety effects. Not only can ashwagandha help you to improve focus and reduce anxiety, but promising research shows ashwagandha can be a powerful anti-inflammatory agent as well.


The amino acid, L-Tyrosine, is a non-essential amino acid that acts as a precursor for certain brain neurotransmitters like dopamine, epinephrine and norepinephrine. Evidence thus far shows that L-Tyrosine is an effective way to improve working memory while under stressful conditions. There is also some evidence to suggest that it is able to enhance creative thought!

Modern humans often get far less sleep than they should and L-Tyrosine can be a useful answer. It will ameliorate the detrimental effects of sleep deprivation to help you stay fresh, alert, and productive throughout the day.

14 Responses to “Knowledge Base”

  1. debra January 5, 2016 at 12:28 pm #

    Please tell me how many milligrams of caffeine and L-Theanine are in the 1-2 Go Formula and why this information is not detailed on the bottle, even my vitamins have this. Also purchased the Piracetam and this also was not listed on the bottle. I had to go to your website to refresh my memory. Why is this pertinent information not listed on the label.
    Thank you. I look forward to your prompt reply.

    • PureNootropics January 6, 2016 at 5:04 pm #

      Hi Debra,

      Thanks for your inquiry, we appreciate your feedback. We’ve had most of our labels redesigned for clarity purposes, and newer bottles of the racetams indicate the amount contained in each capsule. As for the 1-2-Go, the contents and respective quantities are as follows:

      160 mg – L-theanine
      150 mg – Theobromine
      80 mg – Caffeine

      Let us know if you have any other questions or concerns.

  2. Sebastien April 14, 2016 at 11:03 am #


    I did receive my order without any problem an started taking the Piracetam+Aniracetam+Oxiracetam+Choline bundle right away. It’s been about a week now. I can’t really say if I am feeling anything just yet, though. No side effect at all, that’s for sure… Maybe I need to wait a little bit longer before I feel anything new, right ? More later then I guess.
    All the best,

    • PureNootropics April 14, 2016 at 11:34 am #

      Hi Seb,

      We appreciate your business and thank you for taking the time to make an inquiry. What dosages are you taking of each product? Note that we always recommend starting small and increasing dosage (within reason, gives good suggestions on dosing ranges) until you receive the desired result. However, with that said, most would describe racetams as a more subtle nootropic than something like adrafinil, sulbutiamine, or our 1-2-Go product that have a more noticeable effect. Many would describe racetams as giving you a slight edge. Also note that everyone’s biochemistry is different and although many find that choline increases the efficacy of racetams, there are some people that get plenty of choline from diet and supplementing with choline in those instances can actually negatively effect cognition. We’ve also seen instances where one person reacts good to one racetam but not at all to others, so you might want to try varying things up a bit to see what works for you. Feel free to e-mail us regarding your questions, and we’ll do our best to get back to you regarding the same.

  3. Jeffrey Snow May 31, 2016 at 3:36 am #

    I am 67 years old. I go to a gym regularly. My comment is more of a question. Will this supplement cause blood pressure to rise? I tried other’s but they increased my blood pressure so I don’t want to do that again. Please help

    • PureNootropics August 4, 2016 at 1:53 pm #

      We suggest looking at or speaking with your physician about whether the particular ingredient you are interested in has any counter indications related to increased blood pressure.

  4. sharon dent sharon dent July 18, 2016 at 3:14 pm #

    hi there want to purchase supplements is there any difficulties with shipping to australia

    • PureNootropics August 4, 2016 at 1:49 pm #

      International orders must pass customs, this necessarily adds more time to delivery. We will soon be adding additional shipping options to speed up delivery time.

  5. Suzanne Ritchey August 11, 2016 at 4:50 pm #

    Saw about smart drugs HBO special. It stated the Astronauts used a type and Wall Street used a type of these. Can you tell me which ones and I presume if I take a dose it is NOT like taking a RX for anxiety and or an AHD drug where I feel effects in a short time? I get this from reading your comments. I find this interesting. Also, do you make your own compounds and if so what are your qualifications?

    • PureNootropics August 21, 2016 at 6:58 pm #

      Hi Suzanne,

      Well, Phenibut was developed by the Russians and given to cosmonauts to reduce anxiety without inhibiting cognitive function (like many other anti-anxiety medications). Modafinil is prevalent in Wall Street and Silicon Valley, but requires a prescription; it is typically prescribed as an anti-narcolepsy drug and is given to US Air Force pilots to help them stay awake long hours. Some smart drugs will have an immediately noticeable effect, others will be more subtle and sometimes the difference can only be quantified by tracking. We currently do not have a wide assortment of unique offerings/compounds beyond our 1-2-Go, and Optimal Choline Complex. The 1-2-Go was formulated based on the positive studies regarding the combination of l-theanine and caffeine, we simply added theobromine, as it acts similarly to caffeine and gives the blend more of a stimulating factor that we intended to be noticeable by the user. Finally the Choline Complex is a blend of two different Cholinergics (Alpha GPC & Citicoline) that are highly bioavailable. The rest of our products are typical unblended (apart from fillers and excipients, which is standard in capsuled products) ingredients; this allows our customers to develop their own assortment of cognitive enhancement supplements that best suits their individual brain chemistry.

      As far as qualifications, none of the founders of Pure Nootropics are a trained medical doctor, so we always recommend that you speak to your medical provider before taking any new supplements. We have been a part of the nootropics community since 2013 and nootropics users for over a decade. With Pure Nootropics we have sought to provide excellent customer service and maintain the highest product quality (because we take this stuff too).

  6. Jay Stannard December 6, 2016 at 8:57 pm #


    Just ordered something on your site; I would like to become a regular customer of yours. Can you provide me information about any 3rd party tests you have done of your substances?


    • PureNootropics December 20, 2016 at 8:43 am #

      Hi Jay,

      We appreciate your business! We do all of our third party testing through a company called Colmaric Analyticals. We test both for purity and heavy metals, therefore you know you are getting only 99-100% pure product, and that our products don’t have any unwanted substances in them. If the COA isn’t available on our site you can always email us for the most recent batch COA. Please let us know if you have any further questions.

      Thanks again!

  7. Nathan February 3, 2017 at 9:58 am #


    I am considering buying Adrafinil. Do you deliver to the UK?

  8. josh February 4, 2017 at 4:07 pm #

    Does the Alpha GPC powder come with a measuring scoop?


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