Anyone in the nootropics community has probably heard of CILTeP by now whether it was through the Longecity thread started by Abelard Lindsay or other sources. While this article will provide a brief explanation of the concept and more detailed research, the main aim is to discuss:
- Experiences of using CILTeP (both my own and others)
- Interaction between CILTeP and racetams
At Pure Nootropics, we do not currently sell any of the CILTeP ingredients or carry the Natural Stacks version, but the concept is important for smart enhancer users who might add racetams to their stacks. To read a more scientific approach, read Abelard’s post.
Beginners Guide to CILTeP
CILTeP stands for “chemically-induced long-term potentiation”, which is a cellular mechanism in the brain responsible for improving memory and learning. The theory dates back to the late 19th century and studies in 2004 pointed towards methods of supplementing to create this effect.
CILTeP works by doing two main things:
- PDE-4 Inhibition – the phosphodiesterase-4 enzyme typically blocks signals in the brain (and metabolizes cAMP molecules), which can halt more efficient brain activity. CILTeP works by inhibiting the enzyme. Experimentation by Abelard Lindsay suggests that artichoke extract is the best PDE-4 inhibitor available.
- cAMP – the cyclic adenosine monophosphate molecule is responsible for regulating countless functions including adrenaline. Increased cAMP theoretically should increase alertness and productivity. Forskolin (an Indian herb) in very precise dosages should increase cAMP production.
As the theory and formulation progressed, a dopamine enhancing component was added to provide the additional alertness that made “CILTeP as powerful as Modafinil”. Because dopamine is often helpful for alertness, L-phenylalanine was recommended to the artichoke extract + forskolin combination.
CILTeP Effects and Experiences
There have been a variety of effects of CILTeP (both negative and positive) depending on the person. This is the reason why we suggest cognitive tracking as often as possible. One of the downsides of this combination was exhaustion or tiredness.
On the Joe Rogan Experience, Tim Ferriss mentioned how the stack caused him to need 12 hours of sleep the next day. Exaggeration or not, acetyl-L-carnitine helps prevent up-regulation of acetylcholine esterase (by forskolin).
When I took the CILTeP stack, I never felt anything related to tiredness, but this was likely due to the acetyl-L-carnitine support and the fact that I consume copious amounts of eggs.
Some people cycle CILTeP in order to prevent dependency and to allow the body to recover, though Abelard told me he doesn’t need this. I have used CILTeP on an as-needed basis no more than once per day so I have never experienced a need.
My experiences were similar to a “zrbarnes” who said:
“By itself, the combo has an very interesting effect that is hard for me to describe. I don’t know if it has to do with increased blood flow to the brain or what, but about 30 minutes after taking the artichoke/forskolin combo, my head feels… different. Less cramped. More open. Kind of like someone opened the windows to my stuffy attic and let the breeze blow in.”
The only thing that I would add is a sensation of heat, which I would attribute to the increased dopamine metabolism.
Focus and Attentiveness
Many users claimed the primary benefit of the CILTeP formulation was increased attentiveness and focus similar to that of Modafinil. As I have never tried Modafinil, I can’t comment on the comparison. When using CILTeP, I did notice that my hunger was significantly reduced, which allowed me to be more productive (I cook every meal myself, which is time consuming).
This is complete speculation, but I always took CILTeP when in a fasted state (around 14-18 hours) and the reduction in hunger could be related to forskolin’s ability to increase fat metabolism. This disinterest in food may be a bizarre side effect, but it improved concentration on work-related tasks. The acetyl-L-carnitine might be fueling fatty acid oxidation in this scenario as well.
While I can’t verify the strength, numerous users in the smart enhancer community claimed CILTeP was as effective as prescription medication for ADD/ADHD (including Ritalin and amphetamines like Adderall). However, most users identified caffeine as added ingredients to the artichoke extract and forskloin combinations.
Racetam Interactions with CILTeP
NOTE: Even though CILTeP is still technically theoretical (with positive anecdotal evidence), the combination with racetams is even less well known. Proceed with caution.
The popularity of racetams has garnered some interest for combining different analogues with CILTeP. Because racetams modulate AMPA receptors that involve memory encoding, there seems to be a general synergy.
In a recent conversation with Abelard, he mentioned this to be one of the best racetams to stack with CILTeP. For people that want to ease into the CILTeP + racetam combination, this is probably the safest bet. You may need smaller dosages than normal for efficacy. Verdict: Stacks well (anecdotally)
The hyper-potent phenylpiracetam combined with CILTeP is considered highly effective and even “…better than modafinil” according to one person. The same individual noticed that tolerance issues with phenylpiracetam were present, but there were significantly fewer withdrawal symptoms. Verdict: Stacks well (anecdotally)
Evidence suggests that aniracetam does not stack well with CILTeP. Some speculate that the interaction causes aniracetam to act as a GABA like signal inhibitor. The magnitude and duration of negative aniracetam side effects are often amplified when combined with CILTeP. Verdict: Does NOT stack well
There are few reports, but evidence suggests this works similarly to aniracetam. It causes lethargy, lack of motivation, and over-relaxed sensations in some people. Others claim pramiracetam combines well with CILTeP. Verdict: Mixed.