Aniracetam vs. Piracetam – What’s the Difference?

Overview of Aniracetam vs. Piracetam

Within the family of racetams, there are a wide variety of different analogues and compounds with similar structures. Despite the similarity of these racetams at a chemical level, small changes have dramatic impacts on their interaction with the human brain and body.

The most widely known and studied, piracetam, has a longer lasting effect on most individuals, but remains less intensive. Conversely, aniracetam is one of the quickest absorbing racetams with a short half-life and low bioavailability (meaning less enters your bloodstream unchanged).

When questioning aniracetam vs. piracetam, it is important to question the desired results. Both have positive effects on memory and learning in patients who are young or old. However, aniracetam has additional benefits that it can reduce anxiety, fear, depression, and even improve sociability. Some evidence even points towards aniracetam improving concentration and attentiveness.

Those who want to buy aniracetam can also purchase piracetam and get the best of both worlds. By “stacking” (taking more than one) both aniracetam and piracetam, it is possible to feel alert, concentrated, and less anxious for shorter bursts with the piracetam as a longer lasting memory enhancement drug. For complete beginners, it may be best to start with piracetam and note the effects before trying anything else.

The hippocampus is responsible for learning and new memories.

The hippocampus is responsible for learning and creating new memories.

Aniracetam vs. Piracetam Detailed Comparison

Now that you have a general overview of aniracetam vs. piracetam, we can delve into some of the details. Piracetam was the first recognized nootropic drug, which was used to treat motion sickness in the mid-late 1960s. It wasn’t long before scientists discovered the learning and memory benefits in 1971 and found applications immediately thereafter. Studied over the course of the next four decades, piracetam is one of the safest and most well researched cognitive enhancers that are currently available on the market today.

Likewise, aniracetam is a safe cognitive enhancer. Studies of both aniracetam and piracetam show extremely high toxicity levels in humans and rats (meaning that the amount required to be considered toxic is very high). Even with extreme doses of each, there are relatively few side effects. This is one of the reasons that both enhancers are used as parts of combined treatments for many different ailments. Aniracetam was not first reported until 1979, but has also been studied extensively for a better understanding of effects and potential side effects within animal and human brains. Both aniracetam and piracetam are used to treat forms of dementia, Alzheimer’s, and other trauma to the brain with great efficacy.

Benefits of Aniracetam vs. Piracetam

For the entire racetam family, the benefit profile varies slightly, but focuses primarily on memory and learning. That isn’t to say these two are the same, but instead to accentuate the efficacy of both enhancers in producing improved memory and learning in the young and elderly alike.

Aniracetam is responsible for promoting the formation of new synapses in the human brain as well as enhancing the synaptic plasticity. For patients that have damage to the brain, such as trauma, dementia, Alzheimer’s, or similar issues, aniracetam is an incredibly effective neuro-protective agent. However, the benefits of aniracetam also include a variety of mood enhancements as well. Recent evidence suggests that aniracetam can improve feelings of fear, anxiety, and depression among users. In some cases it is even being used as treatment for post-traumatic stress and sleep disorders.

The fact that aniracetam provides such an intense burst (due to the lipophilic nature) means that it can also improve concentration and alertness. Anecdotal evidence from college students suggests that aniracetam can also be used to feel less sleepy or tired.

Piracetam is also a cognitive enhancer that improves memory and learning. Numerous studies on rats and humans show that piracetam can provide neuroprotection and even reduce neuronal loss from trauma or disease. The benefits of using piracetam can be seen in the longer term and has special efficacy in reducing alcohol related neuronal loss.

Doses and Cost – Aniracetam vs. Piracetam

Numerous rat and human studies have provided nootropic users and the scientific community with accurate dose ranges for both aniracetam and piracetam.

For aniracetam, the recommended dosage is 750 mg – 4500 mg, which is typically less than piracetam doses. Because aniracetam has such a powerful, but short effect, it can be taken up to four times a day (with smaller doses). Effective treatment for dementia utilized 1.5 g / day.

The recommended dosage for piracetam is around 1.5 – 6.5 grams depending on the size of the individual and tolerance. While toxicity is usually not a problem, higher doses can obviously cost more money in the long run without providing any additional benefits. Efficacy studies indicate 4.8 g / day is useful for piracetam.

The cost difference between aniracetam and piracetam is small only because higher aniracetam costs are offset by lower dosages. Aniracetam might have a slight edge in cost, but the difference is negligible for the provided reasons.

aniracetam vs. piracetam vs. Piracetam

How Do They Work?

Understanding the mechanism of action for any racetam is a difficult task and scientists have many explanations. According to some, piracetam offers a restoration of membrane fluidity of degraded neuronal cells. Piracetam can also reduce brain glutamate content and the glutamate / GABA ratio.

According to other hypotheses, piracetam modulates steroid sensitive protein synthesis, which is a major part of memory storage and consolidation. Another promising theory cites higher production of acetylcholine, which is a neurotransmitter in the brain that can bind effectively and make faster neurological connections.

Less is known about the mode of action of aniracetam, but similar cholinergic enhancements are expected. This is one of the reasons why many people that supplement with aniracetam and piracetam choose to take choline (a precursor for acetylcholine) as well.

The Decision is Yours

Ultimately, the decision of aniracetam vs. piracetam comes down to your own desires and needs. If you want a short burst of memory enhancers that will also make you more sociable, reduce anxiety, and even increase concentration, aniracetam might be the option for you. If you want a well-researched, studied, and longer term cognitive enhancer that you can start your nootropic journey, piracetam is an excellent starting point.

Thousands of people have tried stacking aniracetam and piracetam together, which provides benefits of both drugs. If taking both aniracetam and piracetam, Pure Nootropics suggests also finding choline supplementation as well for protective purposes. Good luck!

If you have any questions or comments about your experience with aniracetam or piracetam (or both), please let us know below. While anecdotal, other readers benefit from your experiences!



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4 Responses to “Aniracetam vs. Piracetam – What’s the Difference?”

  1. Cliff Hall November 23, 2015 at 7:59 am #

    ” Studies of both aniracetam and piracetam show extremely high toxicity levels in humans and rats.” Don’t you mean “low toxicity”???

    • PureNootropics November 24, 2015 at 4:48 pm #

      Hello and thanks for your comment. To be clear the amount of piracetam or aniracetam needed to be considered toxic is high. Sorry if that was worded in a confusing way.


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